A5003851843- Microscopic Colitis
- Machine Learning in Healthcare
- Lipoproteins and Cardiovascular Health
- Hidradenitis Suppurativa and Treatments
- COVID-19 Clinical Research Studies
- Biochemical Analysis and Sensing Techniques
- Colorectal and Anal Carcinomas
- Artificial Intelligence in Healthcare
- Colorectal Cancer Screening and Detection
- Peripheral Neuropathies and Disorders
- Blood Pressure and Hypertension Studies
- Biomedical Text Mining and Ontologies
- Inflammatory Bowel Disease
- Cardiovascular Health and Risk Factors
- Rheumatoid Arthritis Research and Therapies
- Drug-Induced Ocular Toxicity
- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Pharmaceutical Economics and Policy
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Maternal Mental Health During Pregnancy and Postpartum
- Biotechnology and Related Fields
Janssen (United States)
2018-2025
Johnson & Johnson (United States)
2025
Janssen (Belgium)
2021-2024
SRI International
2023
Menlo School
2023
University of Pittsburgh at Titusville
2023
Metro-Minnesota Community Oncology Research Consortium
2016
Amgen (United States)
2014-2016
Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation emergency use to treat patients COVID-19 pneumonia. We studied safety hydroxychloroquine, alone and combination azithromycin, determine risk routine care arthritis.
Abstract Objective Cohort definition is a bottleneck for conducting clinical research and depends on subjective decisions by domain experts. Data-driven cohort appealing but requires substantial knowledge of terminologies data models. Criteria2Query natural language interface that facilitates human-computer collaboration execution using databases. Materials Methods uses hybrid information extraction pipeline combining machine learning rule-based methods to systematically parse eligibility...
ABSTRACT Background Hydroxychloroquine has recently received Emergency Use Authorization by the FDA and is currently prescribed in combination with azithromycin for COVID-19 pneumonia. We studied safety of hydroxychloroquine, alone azithromycin. Methods New user cohort studies were conducted including 16 severe adverse events (SAEs). Rheumatoid arthritis patients aged 18+ initiating hydroxychloroquine compared to those sulfasalazine followed up over 30 days. Self-controlled case series...
Abstract Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use patients. Here, we describe characteristics adults COVID-19 compare them influenza We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) patients, summarising between 4811 11,643 unique aggregate characteristics. patients have been majority male in US Spain, predominantly female...
Clinical manifestations of hemolytic disease the fetus and newborn include anemia, hyperbilirubinemia, hydrops fetalis, kernicterus, fetal or neonatal demise. More than 50 antibodies are linked to newborn, with Rhesus (including D c) Kell antigens carrying highest risk disease. To date, a multicenter, comprehensive evaluation due antigen alloantibodies in United States has not been undertaken. This study aimed implement novel severity index characterize real-world spectrum from class....
Abstract Background In this study we phenotyped individuals hospitalised with coronavirus disease 2019 (COVID-19) in depth, summarising entire medical histories, including medications, as captured routinely collected data drawn from databases across three continents. We then compared COVID-19 to those previously influenza. Methods report demographics, recorded conditions and medication use of patients the US (Columbia University Irving Medical Center [CUIMC], Premier Healthcare Database...
Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with as for RA.
This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics. The method is based on several diagnostic criteria to evaluate patient cohort returned by PA. Diagnostics include estimates of incidence rate, index date entry code breakdown, and prevalence all observed clinical events prior to, on, after date. We test our one PA systemic lupus erythematosus (SLE) two PAs Alzheimer's disease (AD) across 10 different observational...
Palmoplantar pustulosis (PPP) is a chronic inflammatory condition characterized by sterile pustules on the palms and soles. This study evaluated epidemiology of PPP using claims electronic health record (EHR) databases. Patients coded for in United States (US) Japan from 2016 to 2020 were identified. Several definitions evaluated; specific definition (≥ 2 visits PPP, second 31–730 days after diagnosis) was chosen characterizing epidemiology. Baseline characteristics pre- post-diagnosis...
Abstract We carry out an analysis of gender differences in patterns disease diagnosis across four large observational health datasets and find that women are routinely older when first assigned most diagnoses. Among 112 acute chronic diseases, experience longer lengths time between symptom onset than men for diseases regardless metric used, even only symptoms common to both genders considered. These findings consistent patients with private as well government insurance. Our highlights...
The drug discovery and development industry is under intense pressure to become more efficient develop drugs better, faster, cheaper. Consequently, pharmaceutical biotechnology companies are entering into alliances in an effort utilise each other's talents, exploit specialisations, create value. In this paper, the economics of cycle examined identify economic strategic logic alliances. financial instruments commonly used structure discussed with example case studies.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown origin. The objective this research was to develop phenotype algorithms for SLE suitable use in epidemiological studies using empirical evidence from observational databases.We used process empirically determining and evaluating health conditions be analyzed research. started with literature search discover prior SLE. We then set Observational Health Data Sciences Informatics (OHDSI) open-source tools refine...
Hidradenitis suppurativa (HS) is a chronic, debilitating, inflammatory disease. Contemporaneous real-world data can be used to elucidate the clinical treatment of pediatric patients and how strategies compare with adult hidradenitis patients.
Administrative healthcare claims databases are used in drug safety research but limited for investigating the impacts of prenatal exposures on neonatal and pediatric outcomes without mother-infant pair identification. Further, existing algorithms not transportable across data sources. We developed a linkage algorithm evaluated it two, large US commercially insured populations.We two commercial health insurance during years 2000 to 2021. Mother-infant links were constructed where persons...
PurposeChildren generally have a lower risk of venous thromboembolism (VTE) than adults, but those with acute and chronic conditions requiring hospitalization surgical procedures are at increased risk. Anticoagulant use in children has not been systematically studied, limited data exist. This study aimed to provide on the associated anticoagulants, type anticoagulant used children, incidence major bleeding events reported this population.MethodsTo increase understanding therapies at-risk...
ABSTRACT Objective This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics. Materials and Methods The method is based on several diagnostic criteria to evaluate patient cohort returned by PA. Diagnostics include estimates of incidence rate, index date entry code breakdown, prevalence all observed clinical events prior to, on, after date. We test our one PA systemic lupus erythematosus (SLE) two PAs Alzheimer’s disease...
Hidradenitis suppurativa (HS) is a potentially debilitating, chronic, recurring inflammatory disease. Observational databases provide opportunities to study the epidemiology of HS.This study's objective was develop phenotype algorithms for HS suitable epidemiological studies based on network observational databases.A data-driven approach used 4 algorithms. A literature search identified prior Standardized from Medical Outcomes Partnership (n=9) were 2 incident and prevalent Two open-source...
Introduction: Use observational methods to evaluate reliability of evidence generated by a study the effect glucagon-like peptide 1 receptor agonists (GLP-1RA) on chronic lower respiratory disease (CLRD) outcomes among type-2 diabetes mellites (T2DM) patients. Research Design and Methods: We independently reproduced comparing effects GLP-1RA versus dipeptidyl peptidase-4 inhibitors (DPP4-i) CLRD outcome patients with T2DM prior CLRD. inputs outputs using original data (national...
The goal of our study is to examine the impact lookback length when engineering features use in developing predictive models using observational healthcare data. Using a longer for feature gives more insight about patients but increases issue left-censoring.We used five US databases develop patient-level prediction models. A target cohort subjects with hypertensive drug exposures and outcome cohorts acute (stroke gastrointestinal bleeding) chronic outcomes (diabetes kidney disease) were...
Monitoring risk is often an important component of therapy. Some compounds require liver test (LT) monitoring, with the frequency detailed in product label. Compliance these instructions generally unknown. The goal this short study was to describe LT compliance for monitoring recommended at 2-week intervals or more frequently three US administrative claims databases. sample drawn from databases during period 1 January 2015 through 30 June 2018. This examined nine and five types LTs. We...
ABSTRACT Objectives Concern has been raised in the rheumatological community regarding recent regulatory warnings that hydroxychloroquine used COVID-19 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation, or psychosis associated with as for rheumatoid arthritis (RA). Methods New user cohort using claims and electronic medical records from 10 sources 3 countries (Germany, UK US). RA patients aged 18+ initiating were...
Abstract Aim To assess label compliance in prescription of medications approved for treatment attention‐deficit/hyperactivity disorder (ADHD) Japan at the time this study: methylphenidate (MPH), atomoxetine, and guanfacine. Methods Retrospective descriptive study was conducted prevalent‐user cohorts from Medical Data Center database. Patients who were prescribed a drug between January 1, 2013 September 30, 2018 database ≥30 days included. A considered compliant if all 4 criteria satisfied:...
Abstract Background There has been a more pronounced shift toward earlier, aggressive therapies in Crohn’s disease than ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health care experience, including co-morbidities overall utilization, for UC patients who initiated biologic five years prior initiation first agent. Methods agent approved between 9/15/2005 1/30/2018 were identified from IBM ® MarketScan Commercial claims database. date recorded...
Abstract Background Administrative healthcare claims databases are used in drug safety research but limited for investigating the impacts of prenatal exposures on neonatal and pediatric outcomes without mother-infant pair identification. Objective We developed a linkage algorithm evaluated it two, large US commercially insured populations. Study Design two commercial health insurance during years 2000 to 2021. Mother-infant links were constructed where persons female sex 12-55 age with...