A5045309924- Adsorption and Cooling Systems
- Brucella: diagnosis, epidemiology, treatment
- Refrigeration and Air Conditioning Technologies
- Heat Transfer and Optimization
- Image and Video Quality Assessment
- Advanced Sensor and Control Systems
- Diabetes Treatment and Management
- Cellular transport and secretion
- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Neuroendocrine Tumor Research Advances
- Escherichia coli research studies
- Underwater Vehicles and Communication Systems
- Wireless Sensor Networks and IoT
- Ion Channels and Receptors
- Sperm and Testicular Function
- Flame retardant materials and properties
- Lipid Membrane Structure and Behavior
- Galectins and Cancer Biology
- Advanced Image Fusion Techniques
- Advanced Thermoelectric Materials and Devices
- Supercapacitor Materials and Fabrication
- Visual Attention and Saliency Detection
- Hormonal Regulation and Hypertension
- Thermal properties of materials
Qingdao University
2022-2025
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2018-2025
Janssen (United States)
2025
Jiangnan University
2024
Chongqing Jiaotong University
2022-2023
Guizhou University
2023
Jiangsu Hengrui Medicine (China)
2023
Chengdu University of Traditional Chinese Medicine
2023
Shanghai Jiao Tong University
1998-2020
Ludong University
2018
Synapsin III is the most recently identified member of synapsin family, a group synaptic vesicle proteins that play essential roles in neurotransmitter release and neurite outgrowth. Here, through generation analysis knock-out mice, we demonstrate regulates manner distinct from I or II. In mice lacking III, size recycling pool vesicles was increased, depression reduced. The number fuse per action potential similar between wild-type there no change quantal content EPSCs; however, IPSCs were...
Although synapsins are abundant synaptic vesicle proteins that widely used as markers of presynaptic terminals, the mechanisms target to terminals have not been elucidated. We addressed this question by imaging targeting green fluorescent protein-tagged in cultured hippocampal neurons. Whereas all synapsin isoforms targeted robustly wild-type neurons, Ib scarcely neurons which were knocked-out. Coexpression other significantly strengthened knock-out indicating heterodimerization is required...
To complement and support routine pharmacovigilance, Janssen conducted rapid real-world data analyses for near real-time safety monitoring of the COVID-19 vaccine to contextualize potential signals. Analyses were performed in four U.S. healthcare claims databases (February 2022-May 2023) using standardized algorithms three exposures, 56 outcomes, 93 negative controls. Three self-controlled case series two comparative cohort variants conducted, each with consideration multiple at-risk periods...
To date, a variety of Brucella effector proteins have been found to mediate host cell secretion, autophagy, inflammation, and other signal pathways, but nuclear not yet reported. We identified the first nucleomodulin, BspJ, we screened out BspJ interaction NME/NM23 nucleoside diphosphate kinase 2 (NME2) creatine B (CKB) through yeast two-hybrid co-immunoprecipitation assays. These are related energy synthesis, metabolism, apoptosis pathways. nucleomodulin will decrease expression level NME2...
王克威 a,c ( a 青岛大学药学院 山东青岛 266073) b 青岛科技大学化工学院 266042) c 青岛大学创新药物研究院 266021) 摘要 相比于 1-羟基-7-氮杂苯并三氮唑(HOAt)、1-羟基苯并三唑(HOBt)等传统偶联试剂, 新型多肽偶联试剂 2-肟氰乙 酸乙酯(Oxyma)具有安全、偶联效率高、消旋率低等优势, 在多肽合成特别是微波固相合成中得到广泛应用.但是, 不 同反应温度(例如 28、50 和 75 ℃)对 N,N'-二异丙基碳二亚胺(DIC)/Oxyma 的偶联效率以及对甲硫氨酸(Met)等易氧化氨 基酸的影响尚有待研究.瞬时受体电位锚蛋白 1(TRPA1)通道在感受温度、听觉和炎症痛中发挥重要作用.蝎子毒素多 肽芥末受体毒素(WaTx)是一种新型、非共价结合的 TRPA1 特异性激动剂.本研究利用
We examined the role of SNAPs, soluble proteins that attach N-ethylmaleimide-sensitive factor (NSF), in regulating exocytosis single rat adrenal chromaffin cells. Whole-cell dialysis Ca2+-buffered solution or photolysis caged-Ca2+ was used to manipulate cytosolic Ca2+ concentration ([Ca2+]i), whereas measured via carbon fiber amperometry membrane capacitance. Buffering [Ca2+]i approximately 170 nm produced a mean rate one amperometric event per minute. Including alpha-SNAP (60 500 nm)...
Sertoli cells are crucial for spermatogenesis in the seminiferous epithelium because their actin cytoskeleton supports vesicular transport, cell junction formation, protein anchoring, and spermiation. Here, we show that a junction‐mediating actin‐regulatory (JMY) affects blood–tissue barrier (BTB) function through remodeling of junctional integrity it also contributes to controlling endocytic vesicle trafficking. These functions critical maintenance sperm fertility since loss cell‐specific...
Although pitch-derived carbon foam (CF) is not new, but the progress for enhanced thermal, mechanical, and catalytic dye degradations need to be explored. Numerous works were performed improve structural morphology properties of CFs by dispersing various additives. But mostly it was noticed that such additives one aspect at cost other ones. In this work, additive loadings functionalized graphene oxide (FGO), titanium dioxide (FTiO2) synergistically dispersed into CF matrix via facile...
Recently many attempts were conducted to enhance the structural morphology and properties of pitch-derived carbon foam (CF) by dispersing different additives in CF matrix. But unfortunately, these one property at cost another one. Herein, this work mainly considered collaborated effect multi-walled nanotubes (MWCNTs) functionalized nanodiamonds (FNDs) matrix phase was studied compared with coupled CF/MWCNTs CF/MWCNTs-FNDs hybrid composites. Coal tar pitch (CTP), a raw substance applied...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic inflammation, especially synovitis, leading to joint damage. It important explore potential biomarkers and therapeutic targets improve the clinical treatment of RA. However, underlying mechanisms action available treatments for RA have not yet been fully elucidated. The present study investigated identified specific intervention. A comprehensive analysis was performed using mRNA files downloaded from Gene Expression...
Abstract Aim To assess the safety, tolerability, pharmacokinetics (PKs) and pharmacodynamics of HRS‐7535, a novel glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), in healthy participants. Materials Methods This phase 1 trial consisted single‐ascending dose (SAD), food effect (FE) multiple‐ascending (MAD) parts. In SAD part, participants were randomized (6:2) to receive HRS‐7535 (at doses 15, 60 120 mg; administered orally once daily) or placebo. FE (8:2) single 90‐mg placebo, both fed...
The temperature-sensitive Ca