A5062580306- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Electrolyte and hormonal disorders
- Pharmaceutical studies and practices
- Acute Kidney Injury Research
- Pharmacogenetics and Drug Metabolism
- Vasculitis and related conditions
- Psychiatric care and mental health services
- Potassium and Related Disorders
- Chronic Kidney Disease and Diabetes
- Metabolism and Genetic Disorders
- Analytical Methods in Pharmaceuticals
- Renal function and acid-base balance
- Pregnancy and Medication Impact
- Parathyroid Disorders and Treatments
- Epilepsy research and treatment
- Bipolar Disorder and Treatment
- Diabetes Treatment and Management
- Mental Health Treatment and Access
- Neurological Complications and Syndromes
- Organ Donation and Transplantation
- Statistical Methods in Clinical Trials
University of Massachusetts Chan Medical School
2024
University Hospital Ulm
2010-2023
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2023
Universität Ulm
2006-2022
Helmholtz-Institute Ulm
2021
Universitätsklinik für Kinder und Jugendpsychiatrie
2004-2017
Birmingham VA Medical Center
2015
Creative Research Enterprises (United States)
2015
Semmelweis University
2013
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2012
Objective: Extended daily dialysis (EDD) combines the advantage of both intermittent hemodialysis and continuous renal replacement therapy: excellent detoxification accompanied by cardiovascular tolerability. The aim this study was to evaluate pharmacokinetics meropenem vancomycin in critically ill patients with failure undergoing EDD. Design: Prospective clinical study. Setting: Surgical intensive care unit a tertiary center. Patients: We studied anuric acute being treated EDD receiving (n...
BackgroundKidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive drugs and without evidence rejection are supposed to be exceptional. The ERA-EDTA-DESCARTES working group together with Nantes University launched European-wide survey identify new patients, describe them estimate their frequency for first time.
The prognosis of acute renal failure in patients with preexisting liver decompensation is poor, and hemodialysis considered futile, especially for hepatorenal syndrome (HRS). Since we observed a more favorable outcome some patients, retrospectively evaluated 107 decompensated disease (serum creatinine > 200 mumol/L) treated at the medical department university hospital 10-year period (1980-1990). HRS strict sense (urine-Na < 20 mmol/L while on furosemide) was diagnosed 26 (24%). Renal...
Nephropathia epidemica, caused by Puumala virus (PUUV) infection, is a form of hemorrhagic fever with renal syndrome variable severity. Early prognostic markers for the severity failure have not been established. We evaluated clinical and laboratory parameters 15 consecutive patients acute PUUV which endemic in Alb-Danube region, South Germany. Severe (serum creatinine >620 micromol/L) was observed seven patients; four required hemodialysis treatment. Low platelet count (<60 x 109/L), but...
Cyclosporin A trough blood levels were unusually low during rifampin treatment in a kidney transplant patient. Simultaneously, acute graft rejection occurred. Pharmacokinetic investigation revealed rapid turnover of cyclosporin leading to levels. Cessation therapy reversed these changes. Rifampin substantially reduces the bioavailability and should not be used recipients on A.
Extended daily dialysis (EDD) is increasingly popular in the treatment of acute renal failure (ARF). EDD could remove drugs to a much different degree compared with intermittent standard hemodialysis or continuous replacement therapies; however, there are only scarce data on how influences pharmacokinetics frequently used drugs. The aim this study was determine two quinolone antibiotics patients who had anuric ARF and were being treated EDD. Adult intensive care unit at tertiary university...
In patients with chronic renal failure, secondary hyperparathyroidism (sHPT) is a common problem requiring surgical parathyroidectomy (PTX) if medical treatment active vitamin D and calcimimetics fails. To minimize the risk for recurrence, we perform total PTX (tPTX) without autotransplantation. From October 1997 to January 2004, 46 (31 men 15 women) underwent tPTX autotransplantation (median age 51 years; range 19-80 median dialysis time before 5 0-25 years). Indications were...
ANCA-associated vasculitis is the most frequent cause of crescentic GN. To define new molecular and/or cellular biomarkers this disease in kidney, we performed microarray analyses renal biopsy samples from patients with Expression profiles were correlated clinical data a prospective study ANCA disease. CC chemokine ligand 18 (CCL18), acting through receptor 8 (CCR8) on mononuclear cells, was identified as upregulated chemotactic cytokine newly diagnosed Macrophages and myeloid dendritic...
Besides rejection-induced transplant glomerulopathy, de novo membranous glomerulonephritis (MGN) is the most frequent cause of nephrotic syndrome after renal transplantation. We evaluated 1029 transplantations (271 without and 758 with cyclosporine treatment), performed on 848 patients between 1970 1992, which resulted in 872 functioning grafts. De MGN was seen 30 biopsy specimens from 21 (about 2%), whom 10 had received immunosuppressive treatment 11 cyclosporine. Taking into account longer...
Little is known about hepatotoxicity associated with valproic acid (VPA), a widely used substance in neuropsychiatry. All reported cases to the German Federal Institute for Drugs and Medical Devices between 1993 2009 of VPA-induced serious hepatic side effects were evaluated. A total 132 VPA-associated liver failure identified. Approximately one third (34.8%) occurred under VPA monotherapy, while majority was seen plus co-medication, most frequently antiepileptics benzodiazepines (16.7%)....
Abstract Background After kidney transplantation, pregnancy and graft function may have a reciprocal interaction. We evaluated the influence of on course vice versa. Methods performed retrospective observational study 92 pregnancies beyond first trimester in 67 women after renal transplantation from 1972 to 2019. Pre-pregnancy eGFR was correlated with outcome parameters; by Kaplan Meier analysis. The 28 who became pregnant an < 50 mL/min/1.73m 2 compared control group 79 non-pregnant...