A5021659048- CAR-T cell therapy research
- Virus-based gene therapy research
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Immunotherapy and Immune Responses
- Advanced MRI Techniques and Applications
- Immune Cell Function and Interaction
- Psychotherapy Techniques and Applications
- Neural dynamics and brain function
- Personality Disorders and Psychopathology
- Cardiac Valve Diseases and Treatments
- Mental Health Research Topics
- Cardiac and Coronary Surgery Techniques
- HIV/AIDS drug development and treatment
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Schizophrenia research and treatment
- Psychiatric care and mental health services
- Viral Infectious Diseases and Gene Expression in Insects
- Orthopedic Infections and Treatments
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Epilepsy research and treatment
- Pancreatitis Pathology and Treatment
- Orthopaedic implants and arthroplasty
Cornell University
2024
Bambino Gesù Children's Hospital
2024
Yale New Haven Hospital
2024
Memorial Sloan Kettering Cancer Center
2024
Roma Tre University
2024
University of Zurich
2015-2022
Aarhus University Hospital
2010-2022
Roche Pharma AG (Germany)
2021
Roche (Switzerland)
2021
Universität Ulm
1992-2017
Functional neuroimaging studies on schizophrenia have suggested abnormal task-related functional connectivity in patients with who auditory verbal hallucinations (AVHs). However, little is known about intrinsic these patients.Between January 2009 and February 2010, we studied had persistent treatment-refractory AVHs comparison healthy controls. Using magnetic resonance imaging, the of multiple resting state networks (RSNs) their relation to symptom severity. We analyzed data using a spatial...
Several functional neuroimaging studies have reported regionally abnormal activation of the frontal cortex in individuals with borderline personality disorder (BPD) during cognitive and affective task performance. However, little is known about neural function BPD resting state. Using magnetic resonance imaging (fMRI), this study investigated connectivity prefrontal limbic networks patients BPD.Between January 2009 March 2010, we according to DSM-IV criteria healthy controls by means...
Most systemic viral gene therapies have been limited by sequestration and degradation of virions, innate adaptive immunity, silencing therapeutic genes within the target cells. Here we engineer a high-affinity protein coat, shielding most commonly used vector in clinical therapy, human adenovirus type 5. Using electron microscopy crystallography demonstrate massive coverage virion surface through hexon-shielding scFv fragment, trimerized to exploit hexon symmetry gain avidity. The shield...
T cell–directed cancer immunotherapy often fails to generate lasting tumor control. Harnessing additional effectors of the immune response against tumors may strengthen clinical benefit immunotherapies. Here, we demonstrate that therapeutic targeting interferon-γ (IFN-γ)–interleukin-12 (IL-12) pathway relies on ability a population natural killer (NK) cells with tissue-resident traits orchestrate an antitumor microenvironment. In particular, used engineered adenoviral platform as tool for...
Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor SR-A6 is an entry for human adenoviruses murine alveolar macrophage-like MPI cells, important production type I interferon. Scavenger receptors contribute to clearance endogenous proteins, lipoproteins Knockout anti-SR-A6 antibody or soluble extracellular domain reduced adenovirus type-C5 (HAdV-C5) binding transduction. Expression...
The diagnostic value of the fecal chymotrypsin test (FCT) was reevaluated with regard to (a) proved pancreatic hypofunction different severity (183 pancreozymin-secretin tests); (b) final clinical diagnosis, and (c) fat excretion (208 patients chronic pancreatitis; CP). Progressive disease (cancer, CP) mainly associated moderate or severe (119/138; 86.2%) a low incidence false-normal FCT values (14/138; 10.1%). Miscellaneous disorders (mainly reversible hypofunction) were slight high (17/45;...
Little is known about hepatotoxicity associated with valproic acid (VPA), a widely used substance in neuropsychiatry. All reported cases to the German Federal Institute for Drugs and Medical Devices between 1993 2009 of VPA-induced serious hepatic side effects were evaluated. A total 132 VPA-associated liver failure identified. Approximately one third (34.8%) occurred under VPA monotherapy, while majority was seen plus co-medication, most frequently antiepileptics benzodiazepines (16.7%)....
Adenovirus-mediated combination gene therapies have shown promising results in vaccination or treating malignant and genetic diseases. Nevertheless, an efficient system for the rapid assembly incorporation of therapeutic genes into high-capacity adenoviral vectors (HCAdVs) is still missing. In this study, we developed iMATCH (integrated modular HCAdVs) platform, which enables generation production HCAdVs encoding combinations high quantity purity within 3 weeks. Our cloning facilitates up to...
The goal of cancer-drug delivery is to achieve high levels therapeutics within tumors with minimal systemic exposure that could cause toxicity. Producing biologics directly in situ where they diffuse and act locally an attractive alternative direct administration recombinant therapeutics, as secretion by the tumor itself provides local concentrations a paracrine fashion continuously over extended duration (paracrine delivery). We have engineered SHielded, REtargeted ADenovirus (SHREAD) gene...
Virus entry into host cells is a complex process that largely regulated by access to specific cellular receptors. Human adenoviruses (HAdVs) and many other viruses use cell adhesion molecules such as the coxsackievirus adenovirus receptor (CAR) for attachment target cells. These are rarely expressed on apical side of polarized epithelial cells, which raises question how adenoviruses-and engage molecules-enter from initiate infection. We have previously shown species C HAdVs utilize...
High-field magnetic resonance imaging (MRI) (1.5 T) has recently been introduced into the neurosurgical operating room for intraoperative resection control and functional neuronavigational guidance. However, long-lasting procedures in an equipped with a high-field MRI scanner raise new challenges to anesthesiologist. In particular, monitoring of vital signs during anesthesia requires equipment compatible working close vicinity strong field. even MRI-compatible electrocardiographic (ECG)...
Abstract Recent advances in engineering adenoviruses are paving the way for new therapeutic gene delivery approaches cancer. However, there is limited knowledge regarding impact of adenoviral retargeting on transduction efficiency more complex tumor architectures, and role RGD loop at penton base unclear. To address this gap, we used models increasing complexity to study receptor motif. Employing tumor-fibroblast co-culture models, demonstrate importance motif efficient 2D through epithelial...
Tomophobia refers to fear or anxiety caused by forthcoming surgical procedures and/or medical interventions.We present the case of a 69-year-old Caucasian man who refused urgently indicated intervention because severe tomophobia.Due rising number interventions in modern medicine, as well high unrecognised cases tomophobia, this common but underdiagnosed disorder should be highlighted.
A "valve-in-ring" (ViR) procedure involves the transcatheter implant of a valved stent in prosthetic mitral ring. The presence partial dehiscence ring is major contraindication for ViR due to inefficacious sealing. We describe an alternative method achieve proper valve sealing case dehiscence.A 76-year-old male patient suffered from severe central regurgitation annuloplasty and leaflet tethering. ECG-gated multidetector computed tomography was used preoperative planning. Standard transapical...
Adult patients with borderline personality disorders (BPD) frequently have attachments to inanimate transitional objects (TOs) such as stuffed animals. Using event-related potential (ERP) recordings, we determined in BPD the neural correlates of processing these attachment-relevant and their functional significance. Sixteen female viewed pictures TOs, other familiar toys (familiar objects, FOs), unfamiliar (UOs). ERPs were compared those 16 matched healthy controls who possessed a animal...
Background Micro instability of the hip joint has been suggested to cause pain in patients with dysplasia. Recently, Femoral-Epiphyseal Acetabular Roof (FEAR) index developed evaluate Purpose To investigate associations between FEAR and patient-reported outcomes before six months after periacetabular osteotomy (PAO). Material Methods Radiographs dysplasia who underwent PAO 2018 2020 were retrospectively assessed by a radiologist an orthopedic surgeon. Radiographic measurements indicative...