A5015478319- Reproductive Biology and Fertility
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Estrogen and related hormone effects
- Sperm and Testicular Function
- Hormonal and reproductive studies
- Ovarian cancer diagnosis and treatment
- Gut microbiota and health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Circular RNAs in diseases
- Sexual Differentiation and Disorders
- Immune cells in cancer
- Reproductive System and Pregnancy
- Antioxidant Activity and Oxidative Stress
- Phytoestrogen effects and research
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- PI3K/AKT/mTOR signaling in cancer
- Genetics, Aging, and Longevity in Model Organisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Peking Union Medical College Hospital
2019-2025
Peking University
2021
Endometriosis
2019
Ovariectomy (OVX) conducted before the onset of natural menopause is considered to bringing forward and accelerate process ageing-associated neurodegeneration. However, mechanisms underlying memory decline other cognitive dysfunctions following OVX are unclear. Given that iron accumulates during ageing after OVX, we hypothesized excess accumulation in hippocampus would cause ferroptosis-induced increased neuronal degeneration death associated with decline. In current study, female rats...
Decline in successful conception decreases more rapidly after 38 years of age owing to follicular depletion and decreased oocyte quality. However, limited information is available regarding the underlying mechanism useful treatment. This study aimed evaluate effects growth hormone supplementation on maturation vivo aged young mice determine its effect mitochondrial function. The influence three different doses recombinant human (rhGH) (0.4, 0.8 1.6 mg/kg/day) for 8 weeks before ovarian...
To assess the correlation between clinical and biochemical hyperandrogenism parameters in polycystic ovary syndrome (PCOS) according to age.This prospective study included 256 PCOS patients diagnosed Rotterdam criteria a university-based hospital. Androgen levels were measured using liquid chromatography-tandem mass spectrometry. Hirsutism, acne, alopecia assessed modified Ferriman-Gallwey (mF-G) score, Comprehensive Acne Severity Scale (CASS), Ludwig scale, respectively. The was younger...
After surgical or natural menopause, women face a high risk of nonalcoholic fatty liver disease (NAFLD), which can be diminished by hormone replacement therapy (HRT). The gut microbiota is subject to modulation various physiological changes and the progression diseases. This microbial ecosystem coexists symbiotically with host, playing pivotal roles in immune maturation, defense mechanisms, metabolic functions essential for nutritional homeostasis. E
This study aimed to evaluate the predictive value of initial screening characteristics women with anovulatory polycystic ovary syndrome (PCOS) who did or not respond 2.5 mg letrozole (LET).The clinical and laboratory PCOS underwent LET treatment were evaluated. Women stratified according their responses (2.5 mg). The potential predictors estimated using logistic regression analysis.Our retrospective included 214 eligible patients a response (n = 131) no 83). responded showed better outcomes...
Premature ovarian insufficiency (POI) is a heterogeneous disorder and lacks effective interventions in clinical applications. This research aimed to elucidate the potential effects of recombinant human PEGylated growth hormone (rhGH) on follicular development mitochondrial function oocytes as well parameters POI rats induced by chemotherapeutic agent. The impacts rhGH before superovulation follicles, estrous cycle, sex hormones were evaluated. Oocytes retrieved determine oocyte quality...
Background: Previous studies demonstrated that miRNA-1827 could repress various cancers on proliferation, angiogenesis, and metastasis. However, little attention has been paid to its role in ovarian cancer as a novel biomarker or intervention target, especially clinical significance underlying regulatory network. Methods: A meta-analysis of six microarrays was adopted here determine the expression trend , further validated by gene profile data cellular experiments. We explored functional...
Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disorder, with metabolic abnormalities and ovulation disorders. The post-translational modifications (PTMs) are functionally relevant strengthen the link between metabolism cellular functions. Lysine crotonylation newly identified PTM, function of which in PCOS has not yet been reported. To explore molecular mechanisms involved homeostasis oocyte maturation PCOS, by using liquid chromatography-tandem mass spectrometry...
Study Objective: To generate and validate nomograms to predict any-stage stage III-IV endometriosis before surgery in infertile women. Design: A single center retrospective cohort study Setting: University affiliated hospital Patients: Infertile patients (n=1,016) who underwent reproductive between July 1, 2016 June30, 2019 Interventions: None Main Outcome Measurements: We randomly selected 2/3 of the included (667 patients, training sample) analyze predictive models validated on remaining...
Abstract Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrinopathy that affects reproduction and metabolism. Mammalian target of rapamycin (mTOR) has been shown to participate in female under physiological pathological conditions. This study aimed investigate the role mTOR complex 1 (mTORC1) signaling dehydroepiandrosterone (DHEA)-induced PCOS mice. Results Female C57BL/6J mice were randomly assigned into three groups: control group, DHEA + group. All DHEA-treated...
Abstract Background This multi-center, cross-sectional study intended to explore the prevalence and risk factors of nonalcoholic fatty liver disease (NAFLD) metabolic dysfunction-associated (MAFLD) in patients with polycystic ovary syndrome (PCOS). Methods Patients who met PCOS Rotterdam diagnostic criteria were enrolled 6 centers China, age-matched healthy volunteers also recruited. Data collected including medical history, physical characteristics, blood tests (liver function, lipids,...
Premature menopause is associated with an increased prevalence of nonalcoholic fatty liver disease (NAFLD). Menopausal hormone therapy (MHT) has been widely used in clinical practice and the potential to protect mitochondrial function alleviate NAFLD. After bilateral oophorectomy (OVX), female rats without 17β-estradiol (E2) intervention developed NAFLD, whereas E2 supplementation was effective preventing NAFLD rats. The altered pathways cellular events from both comparison pairs, namely,...
To assess the effect of antiandrogenic pretreatment using combined oral contraceptives (COCs) before ovulation induction in infertile patients with polycystic ovary syndrome (PCOS) hyperandrogenism. Prospective, randomized open-labeled cohort study. Multicenter. PCOS hyperandrogenism and requiring infertility treatments. Randomization to direct letrozole (letrozole group) or ethinylestradiol/cyproterone acetate (EE/CPA) for 3 months subsequent letrozole-induced (EE/CPA+ group). The maximum...
Abstract BackgroundThe interaction between tumor microenvironment (TME) and tumors offers various targets in mounting anti-tumor immunotherapies. However, the diagnostic prognostic biomarkers uterine corpus endometrial carcinoma (UCEC) are still limited. Here, we aimed to analyze TME features identify novel for UCEC. MethodsESTIMATE, CIBERSORT, protein-protein (PPI) network, univariate Cox regression, functional enrichment analysis were performed immune- survival-related hub genes as well...