A5100359914- Liver Disease Diagnosis and Treatment
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Dysphagia Assessment and Management
- Acute Ischemic Stroke Management
- Respiratory viral infections research
- Tracheal and airway disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cervical Cancer and HPV Research
- Sirtuins and Resveratrol in Medicine
- Neuroendocrine Tumor Research Advances
- Herpesvirus Infections and Treatments
- Adipose Tissue and Metabolism
- Systemic Sclerosis and Related Diseases
- Liver Disease and Transplantation
- Voice and Speech Disorders
- Cerebrovascular and Carotid Artery Diseases
- Attention Deficit Hyperactivity Disorder
- Alcohol Consumption and Health Effects
- Pneumonia and Respiratory Infections
- Stroke Rehabilitation and Recovery
- Microbial infections and disease research
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
Southern University of Science and Technology
2025
Yangzhou University
2023-2025
Affiliated Hospital of Nantong University
2022
Nantong University
2022
University of South China
2021
Centre hospitalier universitaire de Québec
2020
Analysis Group (United States)
2014-2019
National Institutes of Health
2015-2019
Northeast Ohio Medical University
2019
National Institute on Alcohol Abuse and Alcoholism
2016-2019
Obesity and alcohol consumption often coexist work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high‐fat diet (HFD) for as little 3 days markedly exacerbated acute ethanol binge–induced liver neutrophil infiltration injury. Feeding with an HFD months plus single binge of induced much more severe steatohepatitis. Moreover, 3‐day or 3‐month HFD‐plus‐ethanol (3d‐HFD+ethanol 3m‐HFD+ethanol) treatment...
Hepatic infiltration of neutrophils is a hallmark steatohepatitis; however, the role in progression steatohepatitis remains unknown.
Background and Aims Nonalcoholic fatty liver disease encompasses a spectrum of diseases ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, cancer. At present, how progresses NASH remains obscure effective pharmacological therapies are lacking. Hepatic expression C‐X‐C motif chemokine ligand 1 (CXCL1), key for neutrophil infiltration (a hallmark NASH), is highly elevated in patients but not livers obese individuals or high‐fat diet (HFD)‐fed mice. The aim this...
Occupational voice users frequently face the challenge of vocal fatigue, impacting their overall well-being and job performance. This study aimed to investigate knowledge, attitude, practice (KAP) toward fatigue among occupational users. web-based cross-sectional was conducted between July October 2023 in Shenzhen People's Hospital, utilizing a self-administered questionnaire examine KAP fatigue. A total 920 valid questionnaires were collected with 248 males 672 females, 34.35% aged 21 30...
Obesity and alcohol consumption synergistically promote steatohepatitis, neutrophil infiltration is believed to be associated with steatosis. However, the underlying mechanisms remain obscure. Peroxisome proliferator–activated receptor gamma (PPARγ) plays a complex role in lipid metabolism inflammation; therefore, purpose of this study was dissect its regulating steatosis clinically relevant mouse steatohepatitis model 3‐month high‐fat diet (HFD) feeding plus binge ethanol (HFD‐plus‐binge...
"Vaccine hesitancy" is a concept frequently used in the discourse around vaccine acceptance. This study aims to contribute ongoing reflections on tools and indicators of hesitancy by providing results knowledge, attitudes beliefs (KAB) survey conducted among parents.Data were collected 2014 through computer-assisted telephone interview administered sample parents children aged between 2 months 17 years age.The majority 589 included analyses agreed importance vaccination protect their...
Pseudomonas aeruginosa is a ubiquitous environmental bacterium that causes variety of infections in humans and animals. Although antibiotic resistance livestock has been extensively documented, continuous surveillance remains crucial for tracking emerging trends assessing control measures. During 2017 2018, 234 strains P. were identified from 1063 pathogenic nonpathogenic bacteria isolated raw milk healthy mastitis cows. In this study, 132 convenience isolates recovered tested antimicrobial...
This study aimed to assess cough effectiveness after a stroke and propose bedside screening test.Patients who had ischemic hemispheric were recruited followed up for 2 mos. Maximum phonation time (MPT) was assessed during the first 10 days. Aspiration evaluated on days stroke. Lung function testing performed day 10. Peak flow less than 160 liters/min defined as criterion ineffectiveness. Correlation between peak MPT determined, optimal cutoff value relating effective determined using...
Interstitial lung disease (ILD) is a common manifestation of scleroderma/systemic sclerosis (SSc). However, the direct and indirect economic burdens SSc-ILD remain unclear. This study assessed compared healthcare resource utilization (HRU), costs, work loss, costs between patients with matched controls neither SSc nor ILD in USA. Data were obtained from large US commercial claims database (2005–2015). Patients (at least 18 years old) had at one diagnosis inpatient (IP) or emergency room (ER)...
Stimulants are recommended as a first-line treatment for attention- deficit/hyperactivity disorder (ADHD); however, subset of the patient population augments their stimulant with other medications. The objective this study was to estimate 1 year period prevalence concomitant psychotropic medication use among children and adolescents ADHD during 2009.Patients 6-17 years age one or more primary diagnoses between July 1, 2008 December 31, 2009 prescription fills were identified from large...
Objective: To evaluate annual concomitant psychotropic medication use among stimulant-treated children/adolescents with ADHD. Method: Children/adolescents ≥1 primary ADHD diagnosis who had received ≥30 days of stimulant were identified from insurance claims for each calendar year (2011-2014). Use 15 medications concomitantly stimulants was evaluated and their prevalence in calculated overall by category children (6-12 years) adolescents (13-17 years). Results: Each 133,354 to 157,303 95,632...
Two vaccines against herpes zoster are currently authorized for use in Canada: the recombinant subunit vaccine and live attenuated vaccine. We compared effectiveness cost-effectiveness of these 2 vaccines.We used a decision analytic static cohort model parametrized with Canadian epidemiologic economic data. performed analysis from health care system perspective, using lifetime horizon 3% discount rate costs benefits. The primary outcome was incremental cost per quality-adjusted life-year...
Objective. To quantify healthcare resource utilization (HRU), work loss, and annual direct indirect costs among patients with systemic sclerosis (SSc) compared to matched controls in the United States. Methods. Data were obtained from a large US commercial claims database. Patients ≥ 18 years old at index date (first SSc diagnosis) had 1 diagnosis inpatient (IP) or emergency room (ER) setting, 2 diagnoses on different dates outpatient (OP) setting between January 1, 2005, March 31, 2015;...
In Quebec, 1 dose of monovalent C meningococcal conjugate vaccine (Men-C-Con) is offered at 12 months age and a booster in grade 9 (14-15 years age). other Canadian provinces, quadrivalent against serogroups ACWY (Men-4-Con) increasingly used for adolescents. An economic analysis was performed to assess the value switch from Men-C-Con Men-4-Con.A compartmental static simulation model developed burden invasive disease due AWY (AWY-IMD) cohort 100,000 persons with different vaccination...
Non‑alcoholic fatty liver disease (NAFLD) is one of the most common types disease, affecting up to 30% general population worldwide. steatohepatitis (NASH) a severe form NAFLD without any effective therapies available. The present study showed that activation α7‑nicotinic acetylcholine receptor (α7 nAChR) may be novel potential strategy for NASH therapy. Treatment with α7 nAChR agonist nicotine three weeks obviously attenuated hepatic steatosis in high-fat diet‑induced mouse model NASH....
A 57-year-old woman with myasthenia gravis (MG), who had experienced a myasthenic crisis, complained of coughing while drinking. At first, this appeared to be sequela the crisis. However, after further investigation, problem was identified as tracheoesophageal fistula, complication tracheostomy. Here, we describe special case in hope that can improve diagnostic accuracy by providing reminder for other physicians consider differences between MG and fistula. It is very important pay more...
To investigate the effects and mechanisms of inflammatory reaction related to nonalcoholic steatohepatitis (NASH) induced by activation cholinergic anti-inflammatory pathway.A mouse model NASH was established feeding a high-fat high-sugar diet.Activation pathway achieved nicotine administration modeled mice normal controls. Liver biopsies were taken concentrations cytokines measured. Isolated liver primary Kupffer cells RAw264.7 cultured, pre-treated or not with lipopolysaccharide (LPS)...
Cytomegalovirus (CMV), a common opportunistic infection among stem cell transplant recipients, is associated with substantial morbidity and mortality. Limited information available regarding the economic consequences of CMV disease these patients. The current study evaluated incremental healthcare costs recipients. Adults were identified in Truven Health MarketScan® database (Q1 2002-Q4 2011). Patients required to have ≥ 2 years continuous enrollment following transplantation. They...