A5021591786- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Herpesvirus Infections and Treatments
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Microscopic Colitis
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Neurological Complications and Syndromes
- Antifungal resistance and susceptibility
- Sepsis Diagnosis and Treatment
- Polyomavirus and related diseases
- Central Venous Catheters and Hemodialysis
- Nosocomial Infections in ICU
- Infective Endocarditis Diagnosis and Management
- Gut microbiota and health
- Hepatitis B Virus Studies
- Hepatitis C virus research
Tufts University
2016-2025
Tufts Medical Center
2015-2024
Infectious Diseases Society of America
2024
Emerson Hospital
2023
University Medical Center
2017
Cleveland Clinic
2001-2016
Heinrich Heine University Düsseldorf
2016
Queen Mary University of London
2016
Medical University of Lodz
2016
Scientific Solutions (United States)
2016
Abstract An epidemic form of arthritis has been occurring in eastern Connecticut at least since 1972, with the peak incidence new cases summer and early fall. Its identification possible because tight geographic clustering some areas, a characteristic preceding skin lesion patients. The authors studied 51 residents three contiguous communities—39 children 12 adults—who developed an illness characterized by recurrent attacks asymmetric swelling pain few large joints, especially knee. Attacks...
Cytomegalovirus (CMV) infection remains a common complication after allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the CMV-terminase complex.In this phase 3, double-blind trial, we randomly assigned CMV-seropositive transplant recipients, 18 years of age or older, in 2:1 ratio to receive letermovir placebo, administered orally intravenously, through week 14 transplantation; randomization was stratified according trial site and CMV disease risk....
Highly active antiretroviral therapy has decreased human immunodeficiency virus (HIV)-associated mortality; other comorbidities, such as chronic liver disease, are assuming greater importance. We retrospectively examined the causes of death HIV-seropositive patients at our institution in 1991, 1996, and 1998–1999. In 1998–1999, 11 (50%) 22 deaths were due to end-stage compared with 3 (11.5%) 26 1991 5 (13.9%) 36 1996 (P = .003). 55% had nondetectable plasma HIV RNA levels and/or CD4 cell...
Sepsis syndrome is a leading cause of mortality in hospitalized patients. However, few studies have described the epidemiology sepsis hospitalwide population.To describe tertiary care hospital setting.Prospective, multi-institutional, observational study including 5-month follow-up.Eight academic centers.Each center monitored weighted random sample intensive unit (ICU) patients, non-ICU patients who had blood cultures drawn, and all received novel therapeutic agent or died an emergency...
We undertook a prospective randomized trial to examine whether an intravenous cytomegalovirus (CMV) immune globulin would prevent primary CMV disease in renal-transplant recipients. Fifty-nine CMV-seronegative patients who received kidneys from donors had antibodies against were assigned receive either or no treatment. The was administered multiple doses over the first four months after transplantation. incidence of virologically confirmed CMV-associated syndromes reduced 60 percent controls...
Intravenously administered ciprofloxacin was compared with imipenem for the treatment of severe pneumonia. In this prospective, randomized, double-blind, multicenter trial, which included an intent-to-treat analysis, a total 405 patients pneumonia were enrolled. The mean APACHE II score 17.6, 79% required mechanical ventilation, and 78% had nosocomial A subgroup 205 (98 ciprofloxacin-treated 107 imipenem-treated patients) evaluable major efficacy endpoints. Patients randomized to receive...
We performed a prospective, international, observational study of 844 hospitalized patients with blood cultures positive for Streptococcus pneumoniae. Fifteen percent isolates had in vitro intermediate susceptibility to penicillin (minimum inhibitory concentration [MIC], 0.12–1 μg/mL), and 9.6% were resistant (MIC, ⩾2 μg/mL). Age, severity illness, underlying disease immunosuppression significantly associated mortality; resistance was not risk factor mortality. The impact concordant...
Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect versus monotherapy on mortality was examined by univariate analyses and logistic regression models. 14-day not significantly different the two groups. However, among critically ill...
Abstract People who inject drugs (PWID) are at risk for infective endocarditis (IE). Hospitalization rates related to misuse of prescription opioids and heroin have increased in recent years, but there no investigations into hospitalizations from injection drug use-related IE (IDU-IE). Using the Health Care Utilization Project National Inpatient Sample (HCUP-NIS) dataset, we found that proportion IDU-IE 7% 12.1% between 2000 2013. Over this time period, detected a significant increase...
Patients colonized with vancomycin-resistant enterococci (VRE) frequently contaminate their environment, but the environmental role of VRE transmission remains controversial.During a 14-month study in 2 intensive care units, weekly and twice-weekly patient surveillance cultures were obtained. acquisition was defined as positive culture result >48 h after admission. To determine risk factors for acquisition, Cox proportional hazards models using time-dependent covariates colonization pressure...
Background: Enterococcus species are major nosocomial pathogens and exhibiting vancomycin resistance with increasing frequency. Previous studies have not resolved whether is an independent risk factor for death in patients invasive disease due to or antibiotic therapy alters the outcome of enterococcal bacteremia. Objective: To determine predictor bacteremia appropriate antimicrobial influences outcome. Design: Prospective observational study. Setting: Four academic medical centers a...
We describe a patient who developed daptomycin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) during an episode of presumed septic thrombophlebitis the portal vein. Although daptomycin is alternative agent for treatment drug-resistant gram-positive bacterial infections, development resistance prolonged use may occur with MRSA bacteremia from persistent focus.
Colonization pressure, proximity to another case, exposure a nurse who cares for enteral feeding, and the use of sucralfate, vancomycin hydrochloride, cephalosporins, or antibiotics are among defined risk factors acquisition vancomycin-resistant enterococci (VRE) in intensive care unit (ICU) setting. However, role rooms with contaminated environmental surfaces has not been well delineated.Retrospective case-control study conducted on patients admitted medical ICU (MICU) tertiary-care,...
Reactivation of varicella zoster virus (VZV) is a common event in patients undergoing allogeneic bone marrow transplantation (BMT) and may lead to life-threatening complications. We retrospectively analyzed the incidence, clinical outcome, risk factors for VZV infections occurring within first 5 years 100 consecutive adults BMT between 1992 1997. Forty-one (41%) developed reactivation median 227 days (range 45-346 days) post-transplantation. Twelve percent occurred 88% 24 months. Among those...
Outcome for 105 patients with candidemia treated amphotericin B was correlated in vitro susceptibility results. Thirty-three had microbiologic failure, which defined as persistence of Candida the bloodstream despite > or = 3 days B. Amphotericin minimum inhibitory concentrations (MICs) were determined by National Committee Clinical Laboratory Standards methodology. After determination MICs, minimal lethal (MLCs) determined. The isolates tested yielded a narrow range MICs (0.06-2 microg/mL);...
There is debate regarding the correlation between in vitro susceptibility testing and clinical response to therapy for bacteroides bacteremia. We conducted a prospective multicenter observational study of 128 patients with Outcome was correlated results Bacteroides isolates recovered from blood and/or nonblood sites, determined use 3 end points: mortality at 30 days, (cure vs. failure), microbiological (eradication persistence). The rate among who received inactive (45%) higher than active...
To study the effect of cytomegalovirus immune globulin (CMVIG) on prevention (CMV) disease and its complications in patients receiving liver transplants.Randomized, multicenter, placebo-controlled, double-blind trial.Four university-affiliated transplant centers Boston (Boston Center for Liver Transplantation).One hundred forty-one recipients completed study.CMVIG or placebo (1% albumin) given a dose 150 mg/kg body weight within 72 hours transplant, then at weeks 2, 4, 6, 8, 100 12...