A5011374275- Infective Endocarditis Diagnosis and Management
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- Otolaryngology and Infectious Diseases
- Cardiac pacing and defibrillation studies
- Streptococcal Infections and Treatments
- Viral Infections and Immunology Research
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- Infectious Diseases and Tuberculosis
- Neutropenia and Cancer Infections
- Herpesvirus Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Genital Health and Disease
- Cytomegalovirus and herpesvirus research
- Orthopedic Infections and Treatments
- Pneumonia and Respiratory Infections
- Actinomycetales infections and treatment
- Infectious Diseases and Mycology
- Infectious Encephalopathies and Encephalitis
Fred Hutch Cancer Center
2023
Wake Forest University
2010-2022
Atrium Health Wake Forest Baptist
1993-2021
National Institutes of Health
2021
National Center for Advancing Translational Sciences
2021
Peacocks Medical Group (United Kingdom)
2017-2019
Thomas Jefferson University Hospital
2017
University of Miami
2017
University of Washington
2017
University of California, Los Angeles
2017
Staphylococcus aureus bacteremia is associated with substantial morbidity. Recurrence common, but incidence and risk factors for recurrence are uncertain. The emergence of methicillin resistance the ease administering vancomycin, especially in patients who have renal insufficiency, led to reliance on this drug assumption that it as effective β-lactam antibiotics, an remains open debate. We initiated a multicenter, prospective observational study 6 university hospitals enrolled 505...
In March 1978, a strain of methicillin-resistant Staphylococcus aureus was introduced from the community into university hospital. Within 6 months admission index case, 5. isolated 30 additional patients, 22 whom were epidemiologically linked by common phage type (6/47/54/75/83A) and roommate-to-roommate spread. Sixteen 31 cases infected, six with bacteremia. Patients infections received cephalosporins more frequently before infection than did control subjects (p < 0.05). acquiring S. in...
Our objectives were to determine the incidence of endocarditis in patients whose Staphylococcus aureus bacteremia was community-acquired, related hemodialysis, or hospital-acquired; assess clinical factors that would reliably distinguished between S. and endocarditis; emergence methicillin-resistant (MRSA) as a cause examine risk for mortality with endocarditis. We conducted prospective observational study 6 university teaching hospitals; we evaluated 505 consecutive bacteremia. Thirteen...
An epidemic strain of methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients at the University Virginia Hospital in Charlottesville (MRSA-Va) was characterized, and virulence properties were compared with those three clinically significant strains methicillin-sensitive S. aureus. Unlike most known MRSA, MRSA-Va sensitive to tetracycline streptomycin exhibited high-level homogeneous methicillin resistance (minimal inhibitory concentration, greater than 128 microgram/ml)....
Staphylococcus aureus is the most common cause of hematogenous vertebral osteomyelitis in adults. To better define clinical features and therapeutic outcomes, charts 40 adult patients with S were retrospectively reviewed.Retrospective chart review using standardized data collection form.S commonly occurred settings recent invasive procedures (55% patients), insulin use (28%), hemodialysis (20%). Ten percent had bacteremia or vascular catheter infection within preceding 6 months. Median time...
This report characterizes the clinical features of 16 cases stroke associated with IV immunoglobulin infusions. Fourteen strokes occurred within 24 hours an infusion and 50% patients were receiving for first time. Nine had multifocal infarctions. All but one risk factors.
Journal Article Epidemiology of Colonization by Nontypable Haemophilus influenzae in Children: A Longitudinal Study Get access Stanley M. Spinola, Spinola From the Departments Pediatrics, Medicine, and Microbiology Immunology, University North Carolina School Chapel Hill, Search for other works this author on: Oxford Academic PubMed Google Scholar James Peacock, Peacock Floyd W. Denny, Denny Dana L. Smith, Smith Janne G. Cannon Please address requests reprints to Dr. Cannon, Department...
surgical ICU had a 24-fold, 10-fold, and eightfold higher rate of nosocomial bloodstream infection, respectively, than did patients on general wards; (3) up to 73%7 at least one intravascular device besides an iv catheter, high proportion (3%-17%7) these subsequently developed infection; (4) constituted large (31%) those infected with gram-negative rods whose infecting organism was resistant aminoglycoside antibiotics; (5) five major outbreaks, which involved 110 (4% patients), were...
Background— Infection is a serious complication of cardiovascular-implantable electronic device implantation and necessitates removal all hardware for optimal treatment. Strategies reimplanting after infection vary widely have not previously been analyzed using large, multicenter study. Methods Results— The MEDIC (Multicenter Electrophysiologic Device Cohort) prospectively enrolled subjects with infections at multiple institutions in the United States abroad between 2009 2012. Reimplantation...
Background Cardiovascular implantable electronic device (CIED) pocket infections are often related to recent CIED placement or manipulation, but these not well characterized. The clinical presentation of infection, based on temporal onset last procedure, deserves further study. Methods MEDIC (Multicenter Electrophysiologic Device Infection Cohort) prospectively enrolled subjects with infection. Subjects were stratified into those whose infection occurred <12 months (early) ≥12 (late)...
Department of Health COVID-19 Response Task ForceHealth care personnel (HCP) are at increased risk for infection with SARS-CoV-2, the virus that causes coronavirus disease 2019 , as a result their exposure to patients or community contacts 2).Since first confirmed case in Minnesota was reported on March 6, 2020, (MDH) has required health facilities* report HCP † exposures persons assessment and enroll higher-risk into quarantine symptom monitoring.During 6-July 11, MDH 1,217 partnering...
Persistent neutrophilic meningitis is a poorly described variant of chronic characterized by the persistence neutrophils in CSF over extended periods time (greater than 1 wk) association with ongoing signs meningeal inflammation and negative cultures for bacteria other pathogens. Although incidence persistent difficult to ascertain, review available literature on CNS infections suggests that this entity not rare. Etiologies syndrome are both infectious noninfectious. Among causes, such as...