A5102894480- Pharmacological Effects of Natural Compounds
- Retinal Development and Disorders
- Metastasis and carcinoma case studies
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Acupuncture Treatment Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Bioactive Compounds
- Pain Management and Placebo Effect
- Psychosomatic Disorders and Their Treatments
- Virus-based gene therapy research
- Cancer-related gene regulation
- Electromagnetic Fields and Biological Effects
- Microbial Metabolism and Applications
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Axon Guidance and Neuronal Signaling
- RNA modifications and cancer
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Beijing Tongren Hospital
2023
Capital Medical University
2016-2023
Beijing Anding Hospital
2016-2021
Beijing YouAn Hospital
2021
National Clinical Research
2020
White matter and myelin sheath integrity are disrupted in schizophrenia, non-invasive magnetic brain stimulation targeting these tracts is a promising new therapeutic approach. In particular, deep-brain reachable low field (DMS) could alleviate cognitive impairment depressive-like behaviors animal models. this study, we sought to assess the effects of DMS on damage schizophrenia-like cuprizone-induced demyelination mouse model. Mice were fed cuprizone (copper ion chelating agent, 0.2% w/w...
Abstract Oxaliplatin-based therapeutics is a widely used treatment approach for hepatocellular carcinoma (HCC) patients; however, drug resistance poses significant clinical challenge. Epigenetic modifications have been implicated in the development of resistance. In our study, employing siRNA library screening, we identified that silencing m 6 A writer METTL3 significantly enhanced sensitivity to oxaliplatin both vivo and vitro HCC models. Further investigations through combined RNA-seq...
Shi-Zhen-An-Shen decoction (SZASD), a Chinese herbal medicine that is liquor extracted from plants by boiling, has been reported to be effective in treating schizophrenia. However, the mechanism unclear. Abnormal demyelination implicated The aim of this study was investigate effect SZASD on myelin demyelinated mice exhibiting schizophrenia-like behaviors. Sixty male C57BL/6 were randomly divided into six groups ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>n</a:mi>...
Abstract Background Our previous study indicated a therapeutic effect of Shi-Zhen-An-Shen-Tang (SZAST), Chinese herb formula, on schizophrenia, but the related mechanism is unknown(citation). A large body evidence suggests important role white matter brain in pathophysiology schizophrenia. This was designed to evaluate SZAST schizophrenia with demyelinated mice. Methods Male C57BL/6 mice were given mixed cuprizone (CPZ, copper chelator, 0.2 %, w/w) rodent chow for six successive weeks induce...
e16140 Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies and leading cause cancer deaths worldwide. Biomarkers contribute to predict response targeted treatments immunotherapy. Therapy directed toward homologous recombination deficiency (HRD) now approved in ovarian breast cancer, but pattern HRD not clear HCC. The phenotype has been defined as presence a non-silent somatic mutation recombination-related (HRR) genes. Thus, we aimed analyze molecular...