A5101581295- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Neurological Disease Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Melanoma and MAPK Pathways
- Liver Disease and Transplantation
- Heavy Metal Exposure and Toxicity
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Traffic and Road Safety
- Neurosurgical Procedures and Complications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- PI3K/AKT/mTOR signaling in cancer
- Safe Handling of Antineoplastic Drugs
- Healthcare and Venom Research
- Parasitic infections in humans and animals
- Organ Donation and Transplantation
- Nuclear Structure and Function
- Ocular and Laser Science Research
China Automotive Engineering Research Institute
2024
Beijing YouAn Hospital
2010-2024
Capital Medical University
2010-2024
Yangzhou University
2024
Hainan General Hospital
2020-2023
Nanjing Medical University
2011-2022
Jiangsu Province Hospital
2022
North China Electric Power University
2022
Hainan Medical University
2020-2021
Huaian First People’s Hospital
2011-2020
Abstract Tertiary lymphoid structure (TLS) can predict the prognosis and sensitivity of tumors to immune checkpoint inhibitors (ICIs) therapy, whether it be noninvasively predicted by radiomics in hepatocellular carcinoma with liver transplantation (HCC‐LT) has not been explored. In this study, is found that intra‐tumoral TLS abundance significantly correlated recurrence‐free survival (RFS) overall (OS). Tumor tissues are characterized inflammatory signatures high infiltration antitumor...
Abstract Objective: To explore the relationships of serum 25-hydroxyvitamin D (25(OH)D) with obesity and metabolic parameters in US children. Design: Cross-sectional analysis. We evaluated associations between 25(OH)D multiple measurements adiposity, lipid concentrations, fasting glucose insulin resistance children aged 6–18 years adjustments for covariates. Setting: The National Health Nutrition Examination Survey, 2001–2006. Participants: A nationally representative sample 6311 adolescents...
Nasal epithelial cells are the first barrier against allergen infiltration in allergic rhinitis (AR), and relationship between nasal mast cell-mediated hypersensitivity remains unclear. This study aimed to investigate possible association allergen-challenged (AR-HNEpC) cell degranulation AR. Our data revealed that calcium influx were increased AR-HNEpC-co-cultured cells. Expression of IL-33, a factor binds ST2 receptors on regulates their degranulation, was elevated AR-HNEpC. Blocking...
Abstract Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in adolescent population. We studied 11,662 subjects included National Health and Nutrition Examination Survey (NHANES) 1999–2012. Blood levels were analysed for their association with (CVRF). Regression coefficients (Beta) 95% confidence intervals (CIs) blood CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, insulin,...
Increasing evidence has shown that abnormal expression of XPO5 is found in many human cancers and acts as an oncoprotein certain cancers. However, its functional role hepatocellular carcinoma (HCC) remains unexplored. In our study, we was highly expressed HCC, which associated with SUMO modification. Moreover, SUMOylated by SUMO2 at K125. Functional experiments revealed SUMOylation could promote MHCC97H cell proliferation, migration invasion. addition, the nuclear export pre-miR-3184...
Objectives The relationship between lipid levels and arterial stiffness remains controversial. Therefore, we aimed to determine the profiles brachial–ankle pulse wave velocity (baPWV) as an indicator of stiffness. Methods A total 909 participants aged 24 84 years were stratified into four baPWV quartiles in our study. Serum lipids, baPWV, other variables measured. Univariable multivariable linear regression analyses used examine relationships parameters baPWV. Results highest quartile group...
Thrombotic complications of atrial fibrillation continue to pose a significant challenge in clinical practice today. Left appendage occlusion (LAAO) has emerged as promising alternative oral anticoagulation for high-risk patients with fibrillation. However, despite the potential benefits, there is still possibility life-threatening such device dislocation. In this case study, we present patient who experienced severe hemodynamic disturbances due embolization LAAO into left ventricular...
Hepatocellular carcinoma (HCC) is the predominant pathological type of liver cancer. Several therapeutic treatments, including sorafenib and regorafenib, have only modestly improved survival in patients with HCC. The aim this study was to investigate expression profiles regulation competitive endogenous RNAs (ceRNAs) sorafenib-related target genes Based on clinical information HCC samples from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, shared differentially expressed...
The majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage that excludes them from potentially curative surgical treatment. Lenvatinib is associated a high objective response rate (ORR) (40.6%) in HCC, indicating the potential for tumor downstaging and conversion to intervention. We report case patient recurrent, HCC who achieved partial following third-line treatment lenvatinib but missed opportunity hepatectomy.A male Chinese aged 42 years presented...
<b><i>Background:</i></b> This study aims to investigate the regulatory effect of microRNA-96-5p (miR-96-5p) in pathophysiological process allergic rhinitis (AR). <b><i>Methods:</i></b> Nasal mucosal tissue samples were collected from AR patients and healthy controls. An vitro model was established by stimulating human nasal epithelial cells (HNECs) with interleukin (IL)-13. The expressions target genes proteins measured qPCR, Western blot, or...
To explore the effects of interventional therapy on human immunodeficiency virus (HIV)-1 Tat interactive protein 2/Tat 30 (HTATIP2/TIP30), B7-H4 and short-term curative effect in primary hepatocellular carcinoma.62 patients with carcinoma admitted our hospital from June 2015 to 2016 were enrolled this study divided into observation group (n = 31) control according random number table. The treated radiofrequency ablation, transcatheter arterial chemoembolization (TACE). both groups received...
Abstract Purpose To study the relationship between TyG index and risk of AAC. Methods We enrolled 1,486 participants from National Health Nutrition Examination Survey (NHANES). The was calculated in log-transformed triglycerides multipled by glucose, presence AAC diagnosed as score above than 0. Results Our suggested found that level positively correlated with score. After adjusted for other variables, comparing lowest quartile index, highest significantly associated (OR 2.12, 95%CI...
Head injury criterion (HIC) companied by a rotation-based metric was widely believed to be helpful for head prediction in road traffic accidents. Recently, the Euro-New Car Assessment Program utilized newly developed called diffuse axonal multi-axis general evaluation (DAMAGE) explain test device human occupant restraint (THOR) injury, which demonstrated excellent ability capturing concussions and injuries. However, there is still lack of comprehensive understanding regarding effectiveness...
Rationale: Hepatic alveolar echinococcosis (HAE) presents a high pathogenicity and case fatality rate. The main treatment for HAE is surgical resection. Giant lesions in the liver invasion of pathogen into retrohepatic inferior vena cava are usually associated with poor prognosis when radical resection cannot be performed. Patient concerns: A 56-year-old man who underwent hydatidectomy 7 years prior noted recurrence HAE. He was subsidized admitted to our hospital purpose treatment....
To evaluate and explore the effectiveness of new prevention control measures for donor-derived infection (DDI) associated with CRO after liver transplantation.The data 120 organ donors recipients from January 2018 to May 2020 were retrospectively analyzed at The Liver Transplantation Center Beijing Youan Hospital, Capital Medical University, investigate epidemiological status in donors. cases divided into two groups. implemented group was treated according execution a clustered measure based...
Objective To investigate effects and safety of dexmedetomidine on the prevention abnormal mental in patients after liver transplantation. Methods 160 transplantation were randomly divided into two groups using drawing method: midazolam group(n=80), compared with general, abnormality occurrence adverse reactions. Results There no significant differences general situation(gender, age, postoperative ventilator time, ICU stay operation blood FK506 concentration, APACHEII score 24...
Objective To explore the effect and molecular mechanism of P13K/Akt signaling pathway on brain tissue undergoing deep hypothermic low flow in mice.Methods The C57BL/6 mice (n =90) were randomly assigned into 3 groups:sham group,model group,and wortmannin group.Model group cerebral ischemia-reperfusion(I-R) underwent then reperfused rewarmed,while sham operation excluded arteries occlusion procedure.The protein expressions akt,p-akt1 p-gsk-3β determined by Western blot mRNA akt1,akt2 akt3...
Objective To review the techniques used in biliary reconstruction for adult-adult living donor liver transplantation using a right lobe graft. Methods The clinical data of 21 pairs and recipient who underwent from April 2007 to May 2009 at Beijing Youan Hospital were analyzed retrospectively. Biliary anastomoses consisted 10 single hepatic duct common anastomoses, 5 double branched ducts between which had been converted by ductoplasty bile duct, 1 hepaticojejunostomy. A T-tube was inserted...