A5007986512- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Fluorine in Organic Chemistry
- Phosphorus compounds and reactions
- Electrochemical sensors and biosensors
- Synthesis of Organic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Synthetic Organic Chemistry Methods
- Advanced biosensing and bioanalysis techniques
- Marine Sponges and Natural Products
- Plant-derived Lignans Synthesis and Bioactivity
- Steroid Chemistry and Biochemistry
- Cyclopropane Reaction Mechanisms
- Biological Activity of Diterpenoids and Biflavonoids
- Electrochemical Analysis and Applications
- Synthesis and Reactions of Organic Compounds
- Axial and Atropisomeric Chirality Synthesis
- Molecular spectroscopy and chirality
- Phytochemistry and Biological Activities
- Molecular Junctions and Nanostructures
- Organophosphorus compounds synthesis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Phytochemical compounds biological activities
- Synthesis and Catalytic Reactions
Northwest A&F University
2012-2024
Kansas State University
2019-2023
Shanghai Institute of Organic Chemistry
2012-2013
Chinese Academy of Sciences
2010-2013
Shanghai Advanced Research Institute
2013
Science North
2012
Hunan University
2006-2010
State Key Laboratory of Chemobiosensing and Chemometrics
2006-2010
Kunming Institute of Botany
2008-2010
Hunan University of Science and Engineering
2007
Pinnigorgiols B and E are 9,11-secosteroids with a unique tricyclic γ-diketone framework. Herein, we report the first synthesis of these natural products from inexpensive, commercially available ergosterol. This features semipinacol rearrangement an acyl radical cyclization/hemiketalization cascade; latter efficiently assembled skeleton, two rings three contiguous stereogenic centers being formed in single step.
There is a strong demand for bioanalytical techniques to rapidly detect protease activities with high sensitivity and specificity. This study reports an activity-based electrochemical method toward this goal. Nanoelectrode arrays (NEAs) fabricated embedded vertically aligned carbon nanofibers (VACNFs) are functionalized specific peptide substrates containing ferrocene (Fc) tag. The kinetic proteolysis curves measured continuously repeated ac voltammetry, from which the catalytic activity...
A 10-step gram-scale synthesis of 9,11-secosteroid pinnisterol E from the inexpensive ergosterol is reported. This features a series highly selective redox transformations such as regioselective olefin hydrogenation (PtO2), acid-sensitive endoperoxide reduction (Al–Ni alloy, Zn), and regio- diastereoselective dienone oxidation. The robustness this strategy clearly demonstrated through formal 11(9 → 7)abeo-steroid pleurocin B divergent 9,11-secosteroids glaciasterol 6-keto-aplidiasterol cholesterol.
Abstract In the presence of 1,8-diazabicycolo[5.4.0]undec-7-ene (DBU) and concentrated H2SO4, 2-naphthol reacted smoothly with α,β-unsaturated trifluoromethyl ketones in CH2Cl2 at room temperature, affording 3-trifluoromethyl-substituted benzo[f]chromene derivatives good to excellent yields a one-pot reaction. [Supplementary materials are available for this article. Go publisher's online edition Synthetic Communications® following free supplemental resource: Full experimental spectral details].
Second-generation chiral-substituted poly-N-vinylpyrrolidinones (CSPVPs) (-)-1R and (+)-1S were synthesized by free-radical polymerization of (3aR,6aR)- (3aS,6aS)-5-ethenyl-tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-one, respectively, using thermal photochemical reactions. They produced from respective d-isoascorbic acid d-ribose. In addition, chiral polymer (-)-2 was also the (S)-3-(methoxymethoxy)-1-vinylpyrrolidin-2-one. Molecular weights these polymers measured HRMS, chain...
Myrmenaphthol A is a structurally unique phenolic steroid with naphthyl AB-ring system and an unusual C2 hydroxy group. Herein, we report the first total synthesis of this natural product in 10 steps from inexpensive, commercially available sitolactone. Key features include Baran decarboxylative coupling Friedel–Crafts cyclization/olefin isomerization/aromatization cascade that rapidly assembled tetracyclic core framework. This synthetic strategy expected to be readily amenable other steroids.
A series of 10 related benzofuran neolignan derivatives were obtained by utilising a biomimetic reaction sequence involving oxidative dimerisation methyl ferulate, followed derivatisation reactions. The structures the new compounds confirmed 1 H NMR, elemental analysis, MS and IR. All evaluated for their cytotoxic potential against five human cancer cell lines (HL-60, SMMC-7721, A-549, SK-BR-3 PAN-1) standard MTT method. results showed that most them exhibit potent cytotoxicity.
Abstract Microbial transformation of pregnane‐3 β ,16 ,20‐triol ( 1 ) by Cunninghamella echinulata afforded four previously unreported polyhydroxylated steroids, namely ,14 α ,20‐tetrol 2 ), pregnane‐3‐oxo‐14 , 16 3 pregnane‐3‐oxo‐7 4 and ,7 5 ). The structures these metabolites were established means spectroscopic analysis (1D 2D NMR as well HRESIMS analysis).
Cascaded Beckmann-transannular protocol transformed macrocyclic beta-caryophyllene into poly-heterocyclic unnatural skeletal types.
A series of trifluoromethyl-substituted 1,2λ<sup>5</sup>-oxaphospholes were prepared in yields up to 95% by a one-pot three-component reaction under mild conditions. The zwitterionic intermediate generated attack triphenylphosphine on an alkyl propiolate reacts with aryl or styryl trifluoromethyl ketone form the 1,2λ<sup>5</sup>-oxaphosphole ring. All new products characterized IR, NMR, and mass spectroscopy structure one them, ethyl...
Abstract Tricyclic pyrone (TP) molecules have shown protection of MC65 neuroblastoma cells death induced by amyloid‐β proteins through SβC gene, a decrease peptide levels, and improvement motor functions memory in Alzheimer's disease mouse rat models. Mechanistic studies suggest TP modulate N ‐methyl‐ D ‐aspartate receptor. A short synthesis chiral analogs was sought using Pd(0)‐catalyzed displacement allylic acetate intermediate with sodium azide or substituted benzylamines. three‐step...
A chiral tricyclic terpene possessing a 6,6,6-tricyclic framework and 3,3-dimethyl-7-oxooctylidenyl side chain undergoes double ring-closing reaction to give two pentacyclic terpenes in ratio of 4:3 via an intramolecular Michael addition followed by aldol condensation under basic conditions. Three new stereogenic centers are introduced the initial annulation reaction. Stereoselective installation ethoxycarbonyl group at C17 separately gives corresponding highly functionalized terpenoids with...
Abstract This method gives 4‐aryl‐substituted pyrazolinones.
Abstract The obtained trifluoromethyl substituted oxetenes are stable in the presence of some Lewis acids.
Abstract Simple three‐component reactions of styryl or aryl trifluoromethyl ketones, ethyl propiolate, and triphenylphosphine are developed for the synthesis 5‐(trifluoromethyl)‐2,5‐dihydro‐1,2λ 5 ‐oxaphospholes under optimized mild reaction conditions.