A5010825030- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Marine Sponges and Natural Products
- Click Chemistry and Applications
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Advanced Breast Cancer Therapies
- Cancer Mechanisms and Therapy
- Multilevel Inverters and Converters
- Cancer Research and Treatments
- Bacillus and Francisella bacterial research
- Power Systems and Renewable Energy
- Microbial Natural Products and Biosynthesis
- Ferroptosis and cancer prognosis
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Bone Tissue Engineering Materials
- Microgrid Control and Optimization
- Connexins and lens biology
- Advanced Thermodynamic Systems and Engines
- Cancer Cells and Metastasis
- Nitric Oxide and Endothelin Effects
- Wound Healing and Treatments
State Grid Corporation of China (China)
2024-2025
WuXi AppTec (China)
2018-2023
Kansas State University
2011-2020
Weifang People's Hospital
2020
In non-synchronous machine sources (N-SMSs), power are connected to the grid through electronic devices, which typically exhibit a voltage-controlled current source characteristic during faults. Due current-limiting feature of inverters, voltage and demonstrate strong nonlinearity. As result, short-circuit (SCC) N-SMSs is commonly calculated using iterative methods. For renewable energy plants, contain large number N-SMSs, calculation often based on single-machine multiplication method,...
Broad-spectrum antifungal activities and mechanism of drimane sesquiterpenoids – Eight including (-)-drimenol (+)-albicanol were synthesized from (+)-sclareolide evaluated for their activities. Three compounds, (-)-drimenol, (+)-albicanol, (1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyl-decahydronaphthalene-1-carbaldehyde (4) showed strong activity against C. albicans. (-)-Drimenol, the strongest inhibitor three, (at concentrations 8 64 µg/ml, causing 100% death various fungi), acts not only...
Cancer cells exhibit many defects in cell communication that contribute to the loss of tissue homeostasis (excess proliferation, invasion, and metastasis). The process cancer formation causes a disruption homeostasis, affecting ability respond extracellular signals, as well triggering some intracellular events which alter gap junctional intercellular (GJIC). Previous research has shown first two generations substituted quinolines have anti-cancer effects human breast cells. This report...
A chiral tricyclic terpene possessing a 6,6,6-tricyclic framework and 3,3-dimethyl-7-oxooctylidenyl side chain undergoes double ring-closing reaction to give two pentacyclic terpenes in ratio of 4:3 via an intramolecular Michael addition followed by aldol condensation under basic conditions. Three new stereogenic centers are introduced the initial annulation reaction. Stereoselective installation ethoxycarbonyl group at C17 separately gives corresponding highly functionalized terpenoids with...
With the large-scale integration of renewable energy into grid, traditional short-circuit current (SCC) calculation methods for synchronous generators are no longer applicable to inverter-based non-synchronous machine sources (N-SMSs). Current SCC N-SMSs often use a single-machine multiplication method, which tends overlook internal variability within power plants, leading low accuracy. To address this issue, paper first derives an analytical expression in grid-connected inverters under...
Abstract Background: The transforming growth factor-β (TGF-β) signaling pathway has been shown to play an important role in various cellular processes including inhibition, cell migration, tumor invasion, epithelial-mesenchymal transition, and immune-suppression. TGF-βs are often overexpressed types of cancers, the anti-TGF-β therapy pursued intensively for cancer treatment. Results: GFH018 is a potent, selective inhibitor TGF-βRI with kinase inhibition activity IC50 70.5 nM. Our studies...
Abstract Breast cancer (BC) has recently surpassed lung to become the most commonly diagnosed in women worldwide. Approximately 70% of BC was ER+, which estrogen receptor α (ERα, encoded by ESR1 gene) drives dysregulated cell proliferation. In clinic, ER+ been effectively treated endocrine therapy targeting or ER. As first approved ERα degrader, fulvestrant proven be effective for locally advanced metastatic BC. However, its clinical utilization is hampered inconvenience intramuscular...
Abstract Pancreatic cancer remains the fourth leading cause of related deaths in United States. Therefore, identification novel strategies to control and treat pancreatic is great importance. GS-19 a compound recently found be GSK inhibitor. In this study, we determined anti-cancer effects cells. treatment inhibited growth Panc-1 BxPC-3 cells concentration-dependent manner. Both cell lines treated with exhibited G-1 cycle arrest as well apoptosis. Western blot analysis both activation...
Abstract The American Cancer Society estimates that over 43,000 new cases of pancreatic cancer are diagnosed each year in the United States, with a five-year survival rate below 6%. Conventional therapies often limited use because resistance development and relapse. Therefore, identification novel strategies to control treat is great importance. GS-19 compound designated as GSK inhibitor shown good activity neural protective assay using MC65 cells. In this study, we determined cytotoxic...
Abstract A series of 14 title compounds type (IV) is tested for anti‐norovirus effects.
22131 Background: In most studies, the effect of steroid hormone receptor (HR) on prognosis was illustrated by survival analysis, which may obscure changes event probability over time. However, such information is highlighted using hazard function. We sought to investigate time-varying prognostic impact HR for breast cancer patients use Similar data still not available at present. Methods: performed a retrospective study 2143 female unilateral undergoing surgery in our hospital from 1992...
Abstract Objective: Endocrine therapy (ET) now is the standard of care (SOC) for ER+ breast cancer treatment. The representative drug ET tamoxifen, a selective estrogen receptor modulator (SERM) that inhibits growth by antagonizing ER function. Tamoxifen displays promising efficacy but also brings problems such as increased endometrial risk and acquired resistance. SERD fulvestrant controls degrading in-cell ER. It shows improved in advanced or tamoxifen-resistant (TamR) patients recently...
ABSTRACT Eight drimane sesquiterpenoids including (-)-drimenol and (+)-albicanol were synthesized from (+)-sclareolide evaluated for their antifungal activities. Three compounds, (-)-drimenol, (+)-albicanol, (1 R ,2 ,4a S ,8a )-2-hydroxy-2,5,5,8a-tetramethyl-decahydronaphthalene-1-carbaldehyde ( 4 ) showed strong activity against C. albicans . (-)-Drimenol, the strongest inhibitor of three, (at concentrations 8 – 64 μg/ml, causing 100% death fungi), acts not only as a fungicidal manner, but...