A5041486989- Genetics, Aging, and Longevity in Model Organisms
- Gut microbiota and health
- Evolution and Genetic Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Insect symbiosis and bacterial influences
- Microbial Community Ecology and Physiology
- Hippo pathway signaling and YAP/TAZ
- Algal biology and biofuel production
- Marine Sponges and Natural Products
- Marine Invertebrate Physiology and Ecology
- Insect Resistance and Genetics
- Pediatric Hepatobiliary Diseases and Treatments
- Antibiotic Resistance in Bacteria
- Glioma Diagnosis and Treatment
- Insect Utilization and Effects
- Methane Hydrates and Related Phenomena
- Mollusks and Parasites Studies
- Single-cell and spatial transcriptomics
- Computational Drug Discovery Methods
- Hybrid Renewable Energy Systems
- Entomopathogenic Microorganisms in Pest Control
- Parasite Biology and Host Interactions
- Agriculture Sustainability and Environmental Impact
- Nematode management and characterization studies
- Nanoparticles: synthesis and applications
University Medical Center Hamburg-Eppendorf
2024-2025
Universität Hamburg
2024-2025
Johannes Gutenberg University Mainz
2024-2025
Max Planck Institute for Chemical Ecology
2021-2025
Kiel University
2014-2020
Max Planck Institute for Evolutionary Biology
2018-2020
Zoological Institute
2019
Host-microbe associations underlie many key processes of host development, immunity, and life history. Yet, none the current research on central model species Caenorhabditis elegans considers worm's natural microbiome. Instead, almost all laboratories exclusively use canonical strain N2 derived mutants, maintained through routine bleach sterilization in monoxenic cultures with an E. coli as food. Here, we characterize for first time native microbiome C. assess its influence nematode history...
The study of microbiomes by sequencing has revealed a plethora correlations between microbial community composition and various life-history characteristics the corresponding host species. However, inferring causation from correlation is often hampered sheer compositional complexity microbiomes, even in simple organisms. Synthetic communities offer an effective approach to infer cause-effect relationships host-microbiome systems. Yet available suffer several drawbacks, such as artificial...
Antibiotic resistance has become one of the most dramatic threats to global health. While novel treatment options are urgently required, attempts focus on finding new antibiotic substances. However, their development is costly, and efficacy often compromised within short time periods due enormous potential microorganisms for rapid adaptation. Here, we developed a strategy that uses currently available antibiotics. Our exploits cellular hysteresis, which long-lasting, transgenerational change...
Almost all animals and plants are inhabited by diverse communities of microorganisms, the microbiota, thereby forming an integrated entity, metaorganism. Natural selection should favor hosts that shape community composition these microbes to promote a beneficial host-microbe symbiosis. Indeed, animal often pose selective environments, which only subset environmentally available able colonize. How assemble after colonization form complex microbiota is less clear. Neutral models based on...
Although the nematode Caenorhabditis elegans is a major model organism in diverse biological areas and well studied under laboratory conditions, little known about its ecology. Therefore, characterization of species' natural habitats should provide new perspective on otherwise well-studied biology. The currently best characterized populations are France, demonstrating that C. prefers nutrient- microorganism-rich substrates such as rotting fruits decomposing plant matter. In order to extend...
How do very small animals with limited long-distance dispersal abilities move between locations, especially if they prefer ephemeral micro-habitats that are only available for short periods of time? The free-living model nematode Caenorhabditis elegans and several congeneric taxa appear to be common in such short-lived environments, example decomposing fruits or other rotting plant material. Dispersal is usually assumed depend on animal vectors, yet all current data based a number studies....
Microbiome communities are complex assemblages of bacteria. The dissection their assembly dynamics is challenging because it requires repeated sampling both host and source communities. We used the nematode Caenorhabditis elegans as a model to study these dynamics. characterized microbiome variation from natural worm populations substrates for two consecutive years using 16S rDNA amplicon sequencing. found conservation in composition across time at genus, but not sequencing variant (ASV)...
Abstract The focus on microalgae for applications in several fields, e.g. resources biofuel, the food industry, cosmetics, nutraceuticals, biotechnology, and healthcare, has gained increasing attention over last decades. In this study, we investigate microbiome of cultured microalga Tetraselmis chui ( T. ) to highlight their potential health benefits. context, biomolecules like antioxidants play a crucial role well-being living organisms as they metabolise harmful reactive oxygen species...
The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, genetic regulators trait variation be mapped on genome using quantitative locus (QTL) analysis recombinant inbred lines (RILs) derived from genetically phenotypically divergent parents. Most RILs have crossing two parents globally distant locations. However, diversity local C....
Abstract Insects engage in manifold interactions with bacteria that can shift along the parasitism–mutualism continuum. However, only a small number of bacterial taxa managed to successfully colonize wide diversity insects, by evolving mechanisms for host-cell entry, immune evasion, germline tropism, reproductive manipulation, and/or providing benefits host stabilize symbiotic association. Here, we report on discovery an Enterobacterales endosymbiont (Symbiodolus, type species Symbiodolus...
Abstract The nematode Caenorhabditis elegans is a central laboratory model system in almost all biological disciplines, yet its natural life history and population biology are largely unexplored. Such information essential for in‐depth understanding of the nematode's because ecology provides context, which traits underlying molecular mechanisms evolved. We characterized phenotypic genetic variation among North German C. isolates. used unique opportunity to compare samples collected 10 years...
The biology of all organisms is influenced by the associated community microorganisms. In spite its importance, it usually not well understood how exactly this microbiota affects host functions and what are underlying molecular processes. To rectify knowledge gap, we took advantage nematode Caenorhabditis elegans as a tractable, experimental model system assessed inducible transcriptome response after colonization with members native microbiota. For study, focused on two isolates genus...
Abstract Almost all animals and plants are inhabited by diverse communities of microorganisms, the microbiota, thereby forming an integrated entity, metaorganism. Natural selection should favor hosts that shape community composition these microbes to promote a beneficial host-microbe symbiosis. Indeed, animal often pose selective environments, which only subset environmentally available able colonize. How assemble after colonization form complex microbiota is less clear. Neutral models based...
ABSTRACT The study of microbiomes by sequencing has revealed a plethora correlations between microbial community composition and various life-history characteristics the corresponding host species. However, inferring causation from correlation is often hampered sheer compositional complexity microbiomes, even in simple organisms. Synthetic communities offer an effective approach to infer cause-effect relationships host-microbiome systems. Yet available suffer several drawbacks, such as...