A5101762368- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition, Genetics, and Disease
- Dementia and Cognitive Impairment Research
- Diet, Metabolism, and Disease
- Machine Learning in Bioinformatics
- Genomics and Rare Diseases
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Biological Research and Disease Studies
- Immune cells in cancer
- Genomics and Chromatin Dynamics
- Fermentation and Sensory Analysis
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Fatty Acid Research and Health
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Asthma and respiratory diseases
- Genetic Syndromes and Imprinting
- Lipid metabolism and biosynthesis
Columbia University Irving Medical Center
2018-2025
Hunan Normal University
2025
Hunan Provincial People's Hospital
2025
Taizhou People's Hospital
2025
Nantong University
2025
Sichuan University of Science and Engineering
2025
Yibin University
2025
Columbia University
2018-2024
Tianjin Medical University
2024
Peking University
2019-2024
Abstract The extent of microglial heterogeneity in humans remains a central yet poorly explored question light the development therapies targeting this cell type. Here, we investigate population structure live microglia purified from human cerebral cortex samples obtained at autopsy and during neurosurgical procedures. Using single RNA sequencing, find that some subsets are enriched for disease-related genes signatures. We confirm presence four these subpopulations histologically illustrate...
Abstract We initiated the systematic profiling of dorsolateral prefrontal cortex obtained from a subset autopsied individuals enrolled in Religious Orders Study (ROS) or Rush Memory and Aging Project (MAP), which are jointly designed prospective studies aging dementia with detailed, longitudinal cognitive phenotyping during life quantitative, structured neuropathologic examination after death. They include over 3,322 subjects. Here, we outline first generation data including genome-wide...
The Alzheimer's Disease Sequencing Project (ADSP) undertook whole exome sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls primarily of European ancestry (EA), among whom 218 177 were Caribbean Hispanic (CH). An age-, sex- APOE based risk score family history used to select most likely harbor novel AD variants least develop by age 85 years. We tested ~1.5 million single nucleotide (SNVs) 50,000 insertion-deletion polymorphisms (indels) for...
Human microglial heterogeneity is only beginning to be appreciated at the molecular level. Here, we present a large, single-cell atlas of expression signatures from 441,088 live microglia broadly sampled across diverse set brain regions and neurodegenerative neuroinflammatory diseases obtained 161 donors autopsy or during neurosurgical procedure. Using hierarchical Poisson factorization (scHPF), derived 23-factor model for continuous gene which capture specific biological processes (e.g.,...
As the primary raw material for Baijiu brewing, sorghum variety exerts an intricate influence on taste profile of strong-flavor Baijiu. However, how comprehensively affects flavor formation through fermentation by microorganisms and metabolites remains largely unknown. Using 16S&ITS rRNA gene sequencing non-targeted metabolomics, in this study we analyzed changes microbial communities during a glutinous non-glutinous variety. The results showed that these varieties significantly affected...
Genetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated.
Genetic understanding of complex traits has developed immensely over the past decade but remains hampered by incomplete descriptions contribution to phenotypic variance. Gene-environment (GxE) interactions are one these contributors and in guise diet physical activity important modulators cardiometabolic phenotypes ensuing diseases.We mined scientific literature collect GxE from 386 publications for blood lipids, glycemic traits, obesity anthropometrics, vascular measures, inflammation...
RNA editing is a feature of maturation resulting in the formation transcripts whose sequence differs from genome template. Brain may be altered Alzheimer's disease (AD). Here, we analyzed data 1,865 brain samples covering 9 regions 1,074 unrelated subjects on transcriptome-wide scale to identify inter-regional differences editing. We expand list known events by identifying 58,761 previously unreported events. note that only small proportion these are found at protein level our proteome-wide...
Abstract INTRODUCTION Multi-omics studies in Alzheimer’s disease (AD) revealed many potential pathways and therapeutic targets. Despite their promise of precision medicine, these lacked African Americans (AA) Latin (LA), who are disproportionately affected by AD. METHODS To bridge this gap, Accelerating Medicines Partnership AD (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors. RESULTS We generated data curated harmonized phenotypic from AA (n=306), LA (n=326), or (n=4)...
Abstract INTRODUCTION Multi‐omics studies in Alzheimer's disease (AD) revealed many potential pathways and therapeutic targets. Despite their promise of precision medicine, these lacked Black Americans (BA) Latin (LA), who are disproportionately affected by AD. METHODS To bridge this gap, Accelerating Medicines Partnership Disease (AMP‐AD) expanded brain multi‐omics profiling to multi‐ethnic donors. RESULTS We generated data curated harmonized phenotypic from BA ( n = 306), LA 326), or 4)...
<h3>Importance</h3> Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular<i>APOE</i>alleles. <h3>Objective</h3> To identify<i>APOE</i>genotype-dependent infrequent and rare using whole-exome sequencing. <h3>Design, Setting, Participants</h3> The discovery stage included 10 441 non-Hispanic white participants in the Disease Sequencing Project. Replication was sought 2 independent,...
Abstract Background Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these different cell types, well their role AD pathology still remains unclear. Methods Utilizing antibodies targeting specific epitopes human post-mortem tissue and analyzing mRNA expression data from purified microglia, we identified three neurons astrocytes (isoforms 1, 2 3)...
Scope Omega‐3 PUFAs ( n ‐3 PUFAs) reduce IL‐6 gene expression, but their effects on transcription regulatory mechanisms are unknown. We aimed to conduct an integrated analysis with both population and in vitro studies systematically explore the relationships among PUFA, DNA methylation, single nucleotide polymorphisms (SNPs), protein concentration of IL6 . Methods results Using data Genetics Lipid Lowering Drugs Diet Network (GOLDN) study Encyclopedia Elements (ENCODE) consortium, we found...
Summary Although apolipoprotein E ( APOE ) variants are associated with age‐related diseases, the underlying mechanism is unknown and DNA methylation may be a potential one. With data, measured by Infinium Human Methylation 450 array, from 993 participants (age ranging 18 to 87 years) in Genetics of Lipid Lowering Drugs Diet Network GOLDN study, Encyclopedia Elements ENCODE consortium, combined published datasets, we described pattern 13 CpG sites within locus, their correlations gene...
Cervical lymph node metastasis is a major factor influencing recurrence after surgery for papillary thyroid cancer. Molecular markers that can predict the presence of and assess aggressiveness microcarcinoma (PTMC) remain poorly understood. The research question addressed whether specific genes, such as thrombospondin-4 (THBS4), could serve predictive biomarkers guiding surgical strategies, particularly in cases where current imaging modalities fail to detect LNM central region, decision...
The apolipoprotein E4 allele (APOEϵ4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet its molecular impact on cerebrovascular biology remains inconclusive, particularly in underrepresented populations with elevated vascular burden. Individuals from Hispanic ancestry experience disproportionately high rates of pathology, offering a unique opportunity to investigate mechanisms pathology AD. Here, we performed single-nucleus RNA sequencing (snSeq) 413,175...