A5012554916- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Surfactants and Colloidal Systems
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Molecular Sensors and Ion Detection
- Graphene and Nanomaterials Applications
- Protein Interaction Studies and Fluorescence Analysis
- Inhalation and Respiratory Drug Delivery
- Ecology and Vegetation Dynamics Studies
- Tree-ring climate responses
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Pharmacological Effects and Toxicity Studies
- Plant Water Relations and Carbon Dynamics
- Polymer-Based Agricultural Enhancements
- Forest Ecology and Biodiversity Studies
- Protein purification and stability
- Plant Physiology and Cultivation Studies
- Renal Transplantation Outcomes and Treatments
- Biochemical Analysis and Sensing Techniques
Fudan University
2016-2025
Shenyang Normal University
2008-2024
Guilin University of Electronic Technology
2016-2024
Commercial Aircraft Corporation of China (China)
2014
Affiliated Hospital of Hangzhou Normal University
2013
First People's Hospital of Yuhang District
2012
Hangzhou Normal University
2012
Xi'an University of Technology
2012
Northeast Forestry University
2008
Abstract Deep tissue imaging in the second near‐infrared (NIR‐II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to absorption and scattering hampers its application accurate vivo biosensing. Here, lifetime‐based situ hepatocellular carcinoma (HCC) detection NIR‐II region is presented using a tumor‐microenvironment (peroxynitrite, ONOO − )‐responsive lanthanide–cyanine Förster resonance energy transfer (FRET) nanosensor. A...
Abstract Organic dyes emitting in the second near‐infrared (NIR‐II, 900–1700 nm) window, with high molar extinction coefficients (MEC) and quantum yields (QY) aqueous, are essential for vivo bioimaging biosensing. In this work, we developed a dibodipy‐based aggregation‐induced emission (AIE) fluorescent probe, THPP , to meet aim. exhibits MEC has intensified absorption J‐aggregated state, which significantly enhance fluorescence intensity (≈55 folds) extend maximal absorption/emission...
Inflammation usually results in high-level reactive oxygen species (ROS) and nitrogen (RNS) not only acidic tissue but also alkaline tissue. However, noninvasively vivo monitoring specifically within remains a huge challenge. Here we introduce dual activatable fluorescent probe PN910 located the second near-infrared window (NIR-II, 900-1700 nm), which shows high selectivity toward H2 O2 OONO- at pH beyond 7.4. Then verified that could be used for real-time, specific accurate of cystitis...
The nose-to-brain pathway has been proven to be a shortcut for direct drug delivery the brain. However, whether and what extent nanoparticles can delivered through this passage is still awaiting validation with evidence. In study, transportation of tracked via fluorescence bioimaging strategies using nanoemulsions (NEs) as model carriers. Identification NEs in biological tissues based on → off signal switching new type environment-responsive embedded dyes, P2 P4, two conventional probes, DiR...
Abstract Environment‐responsive fluorophores with aggregation‐caused quenching (ACQ) properties have been applied to track nanocarriers reduced artefacts caused by unbound or free but suffer from incomplete fluorescence and significant re‐illumination, which undermine bioimaging accuracy. Herein, through structural modifications reinforce the hydrophobicity, planarity rigidity of an aza‐BODIPY framework, probes featuring absolute ACQ (aACQ) negligible re‐illumination are developed evaluated...
Geometry has been considered as one of the important parameters in nanoparticle design because it affects cellular uptake, transport across physiological barriers, and vivo distribution. However, only a few studies have conducted to elucidate influence geometry their fate after oral administration. This article discloses effect shape on absorption gastrointestinal (GI) tract. Nanorods nanospheres were prepared labeled using fluorescence resonance energy transfer molecules track intact...
The long-circulating effect is revisited by simultaneous monitoring of the drug payloads and nanocarriers following intravenous administration doxorubicin (DOX)-loaded methoxy polyethylene glycol-polycaprolactone (mPEG-PCL) nanoparticles. Comparison kinetic profiles both DOX verifies effect, though limited degree, as a result pegylation. nanocarrier display fast clearance from blood despite dense PEG decoration; cleared faster than nanocarriers. circulate longer in blood, suggesting possible...
In vitro dissolution that predicts the in vivo performance of solid preparations is extremely important formulation optimization. Fraction absorbed (Fa) has been used to screen protocols based on idea vitro–in correlation (IVIVC) but failed increase success rate due inaccuracy Fa. The essence IVIVC between and dissolution. We tried establish protocol via similarity with using aripiprazole (APZ) as a model drug. Hybrid APZ crystals (APZ-HCs) were prepared by physically embedding...
Accurate fluorescence imaging of nanocarriers in vivo remains a challenge owing to interference derived mainly from biological tissues and free probes. To address both issues, the current study explored fluorophores near-infrared (NIR)-II window with aggregation-caused quenching (ACQ) properties improve accuracy. Candidate NIR-II emission, ACQ984 (λem = 984 nm) IR-1060 1060 nm), aza-BODIPY cyanine families, respectively, were compared commercial fluorophore ICG tail emission NIR-I P2 family....
One of the biggest challenges in bioimaging nanoparticles is how to identify integral particles from bulk signals probes. Signals free probes are always mistakenly counted into total particles. In this study, vivo fate intravenous polymeric micelles (PMs, mPEG2.5k–PDLLA2.5k) was explored using a highly sensitive near-infrared environment-responsive fluorescent probe. This probe able emit fluorescence when embedded nanocarriers but quench spontaneously and absolutely upon release water, based...
Biomimetic nanocarriers are emerging as efficient vehicles to facilitate dietary absorption of biomacromolecules. In this study, two vitamins, thiamine and niacin, employed decorate liposomes loaded with insulin, thus facilitating oral
Taking advantage of its ability to deal with exogenous pathogens, the M cell passage has proven be most reliable pathway for entry particulates, thus creating opportunities oral immunization and delivery biomacromolecules. Albeit a well-known story, underlying mechanisms this are not yet well understood, especially concerning direct evidence translocation particulates. Herein, model glucan microparticles (GMs) targeting cells employed track through pathways as various organs via systemic...
Fast drug release leads to divergent kinetics of paclitaxel and mPEG-PCL nanoparticles, justifying an updated understanding long circulation.
Abstract Probing the onset of micellization, or determining critical micelle concentration (CMC), is crucial importance while remains to be challenged by growing demand for extraordinary sensitivity and accuracy. Although fluorometry has attracted wide attention owing its superiority in simplicity over other methods, presence fluctuation background fluorescence conventional fluorescent probes undermine accuracy CMC determination. Herein, a series novel without at below absolute...