A5103026290- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced Nanomaterials in Catalysis
- Electrocatalysts for Energy Conversion
- Luminescence Properties of Advanced Materials
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Photoacoustic and Ultrasonic Imaging
- Fuel Cells and Related Materials
- Advanced battery technologies research
- Supercapacitor Materials and Fabrication
- Advanced Sensor and Energy Harvesting Materials
- Molecular Sensors and Ion Detection
- Photodynamic Therapy Research Studies
- Advanced Photocatalysis Techniques
- Advanced Cellulose Research Studies
- Quantum Dots Synthesis And Properties
- Advancements in Battery Materials
- Nanocluster Synthesis and Applications
- Advanced Battery Materials and Technologies
- Nanopore and Nanochannel Transport Studies
- Extraction and Separation Processes
- Sulfur Compounds in Biology
- Graphene and Nanomaterials Applications
Fudan University
2017-2025
National University of Singapore
2022-2024
Zhejiang Sci-Tech University
2024
Xi'an Shiyou University
2024
Zhengzhou University
2023
Yunnan University
2022-2023
University of Macau
2021-2023
Jiaxing University
2022
Tianjin University
2020-2021
Beijing Normal University
2021
Abstract A small‐molecule fluorophore FD‐1080 with both excitation and emission in the NIR‐II region has been successfully synthesized for vivo imaging. heptamethine structure is designed to shift absorption into region. Sulphonic cyclohexene groups are introduced enhance its water solubility stability. The quantum yield of 0.31 %, can be increased 5.94 % after combining fetal bovine serum (FBS). Significantly, 1064 nm was demonstrated high tissue penetration depth superior imaging...
Light in the second near-infrared window, especially beyond 1500 nm, shows enhanced tissue transparency for high-resolution vivo optical bioimaging due to decreased scattering, absorption, and autofluorescence. Despite some inorganic luminescent nanoparticles have been developed improve around it is still a great challenge synthesize organic molecules with absorption emission toward this region. Here, we present J-aggregates 1360 nm 1370 formed by self-assembly of amphiphilic cyanine dye...
Tumor hypoxia is typically presented in the central region of solid tumors, which mainly caused by an inadequate blood flow and oxygen supply. In conventional treatment hypoxic human not only oxygen-dependent photodynamic therapy (PDT), but also antitumor drug-based chemotherapy, considerably limited. The use direct delivering approach with PDT or chemotherapy may potentiate reactive species (ROS)-mediated cytotoxicity drug toward normal tissues. Herein, a synergetic one-for-all mesoporous...
Local recurrence is a common cause of treatment failure for patients with solid tumors. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and, thereby prognosis. Here, we report vivo assembly the second near-infrared window (NIR-II) emitting downconversion nanoparticles (DCNPs) modified DNA targeting peptides to image-guided metastatic ovarian cancer. The NIR-II quality DCNPs superior that clinically approved ICG good...
Real-time monitoring of vessel dysfunction is great significance in preclinical research. Optical bioimaging the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, reported molecular dyes are hampered by limited blood circulation time (~ 5-60 min) short absorption emission wavelength, which impede accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with beyond 1000 nm. Thanks to long (half-life 3.2 h),...
The low-efficiency cellular uptake property of current nanoparticles greatly restricts their application in the biomedical field. Herein, we demonstrate that novel virus-like mesoporous silica can easily be synthesized, showing superior property. unique with a spiky tubular rough surface have been successfully synthesized via single-micelle epitaxial growth approach low-concentration-surfactant oil/water biphase system. nanoparticles' morphology results mainly from nanotubes spontaneously...
Oxidative stress and a series of excessive inflammatory responses are major obstacles for neurological functional recovery after ischemic stroke. Effective noninvasive anti-inflammatory therapies urgently needed. However, unsatisfactory therapeutic efficacy current drugs inadequate drug delivery to the damaged brain problems. Nanozymes with robust antioxidative properties possess possibility insufficiency nanozyme accumulation in by administration hindered their application. Herein, we...
Abstract Bioluminescence imaging has been widely used in life sciences and biomedical applications. However, conventional bioluminescence usually operates the visible region, which hampers high-performance vivo optical due to strong tissue absorption scattering. To address this challenge, here we present probes (BPs) with emission second near infrared (NIR-II) region at 1029 nm by employing resonance energy transfer (BRET) two-step fluorescence (FRET) a specially designed cyanine dye...
Abstract Deep tissue imaging in the second near‐infrared (NIR‐II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to absorption and scattering hampers its application accurate vivo biosensing. Here, lifetime‐based situ hepatocellular carcinoma (HCC) detection NIR‐II region is presented using a tumor‐microenvironment (peroxynitrite, ONOO − )‐responsive lanthanide–cyanine Förster resonance energy transfer (FRET) nanosensor. A...
In the past decade, fluorescence bioimaging in second near-infrared (NIR-II, 1000–1700 nm) window has shown great potential both fundamental research and preclinical diagnosis prognosis, owing to high resolution at deep penetration decreasing light absorption scattering. Compared inorganic contrast agents, NIR-II organic dyes are more promising for biological application due low molecular mass, good biocompatibility, flexible design. this review, current chemical structures applications of...
Abstract Organic dyes emitting in the second near‐infrared (NIR‐II, 900–1700 nm) window, with high molar extinction coefficients (MEC) and quantum yields (QY) aqueous, are essential for vivo bioimaging biosensing. In this work, we developed a dibodipy‐based aggregation‐induced emission (AIE) fluorescent probe, THPP , to meet aim. exhibits MEC has intensified absorption J‐aggregated state, which significantly enhance fluorescence intensity (≈55 folds) extend maximal absorption/emission...
Abstract Contrast agents for bioimaging suffer from low accumulation at lesion area and high uptake in the reticuloendothelial system (RES). Assembly of nanoparticles vivo improves their enrichment tumors inflamed areas. However, uncontrollable assembly also occurs liver spleen owing to by RES. This is known probably cause a higher background more severe health hazards, which may hamper clinical application. Herein, new near‐infrared (NIR)‐controlled supramolecular engineering strategy...
Abstract To improve the bioimaging signal‐to‐noise ratio (SNR), long‐term imaging capability, and decrease potential biotoxicity, an in vivo cross‐linking strategy was developed by using sub‐10 nm, glutathione‐modified, lanthanide nanoprobes. After administration, nanoprobes cross‐link response to reactive oxygen species (ROS) at inflamed area enable quick of ROS second near‐infrared (NIR‐II) window. These could be rapidly excreted due their ultra‐small size. This may also applied other...
Abstract Photon excitation and emission at the NIR‐II spectral window enable high‐contrast deep‐tissue bioimaging. However, multiplexed imaging with has been hampered by limited chemical strategies to develop bright fluorophores tunable absorption in this regime. Herein, we developed a series of heptamethine cyanines (HCs) varied absorption/emission maxima spanning from 1100 1600 nm through physical organic approach. A bulky counterion paired HCs was found elicit substantial improvements...
Abstract A small‐molecule fluorophore FD‐1080 with both excitation and emission in the NIR‐II region has been successfully synthesized for vivo imaging. heptamethine structure is designed to shift absorption into region. Sulphonic cyclohexene groups are introduced enhance its water solubility stability. The quantum yield of 0.31 %, can be increased 5.94 % after combining fetal bovine serum (FBS). Significantly, 1064 nm was demonstrated high tissue penetration depth superior imaging...
Monitoring the pH in tumor lesions provides abundant physiological information. However, currently developed sensors only achieve sensitive detection settled response region around transition point (pH
Size and charge dual-transformable core@satellite structured nanoassemblies are developed to overcome multiple biological barriers in a drug delivery system.
Abstract Early detection of kidney disease is vital importance due to its current prevalence worldwide. Fluorescence imaging, especially in the second near‐infrared window (NIR‐II) has been regarded as a promising technique for early diagnosis superior resolution and sensitivity. However, reported NIR‐II organic renal‐clearable probes are hampered by their low brightness ( ϵ max Φ f>1000 nm <10 M −1 cm ) limited blood circulation time t 1/2 <2 h), which impede targeted imaging...