A5073126909- Layered Double Hydroxides Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Nanowire Synthesis and Applications
- Polyoxometalates: Synthesis and Applications
- Inorganic Chemistry and Materials
- Analytical Chemistry and Sensors
- ATP Synthase and ATPases Research
- Viral gastroenteritis research and epidemiology
- Advanced Photocatalysis Techniques
- Animal Virus Infections Studies
- Hepatitis C virus research
- interferon and immune responses
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- thermodynamics and calorimetric analyses
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Genetics, Bioinformatics, and Biomedical Research
- Synthesis and biological activity
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
Kookmin University
2012-2024
Pusan National University
2017
Seoul National University of Science and Technology
2017
Rutgers, The State University of New Jersey
2005-2013
Sungshin Women's University
2011
Samsung (South Korea)
2006
Inje University
2005
Kitakyushu Foundation for the Advancement of Industry, Science and Technology
2004
Nagoya Institute of Technology
2004
The University of Kitakyushu
2004
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTIntercalative Nanohybrids of Nucleoside Monophosphates and DNA in Layered Metal HydroxideJin-Ho Choy, Seo-Young Kwak, Jong-Sang Park, Yong-Joo Jeong, Josik PortierView Author Information Department Chemistry, Center Molecular Catalysis Seoul National University, Seoul, 151-742, Korea Institut de Chimie la Matière, Condensée Bordeaux 33608 Pessac, France Cite this: J. Am. Chem. Soc. 1999, 121, 6, 1399–1400Publication Date (Web):February 3,...
A biomolecular–inorganic hybrid is formed from anionic biomolecules (such as DNA fragments, ATP, or an antisense oligonucleotide) intercalated in a cationic Mg/Al layered double hydroxide (see picture). Such can be used to deliver drugs genes the inorganic noncytotoxic carrier. Cellular uptake experiments confirm this, with carrier dissolving slowly leukemia cell, and thereby releasing its growth-inhibiting load.
Eine bioorganisch-anorganische Hybridverbindung wird aus anionischen Biomolekülen gebildet (z. B. DNA-Fragmenten, ATP oder Antisense-Oligonucleotiden), die in einem kationischen Mg/Al-Doppelhydroxid intercaliert sind (siehe Bild). Mit derartigen Hybridsystem können Wirkstoffe auch Gene transportiert und dem anorganischen, nicht cytotoxischen Carrier freigesetzt werden. Dies wurde durch Experimente belegt, bei denen sich der einer Leukämiezelle unter Abgabe wachstumshemmenden "Fracht" langsam auflöst.
We apply a voltage pulse to electrically excite the incompressible region of two-dimensional electron liquid in $\nu=2/3$ fractional quantum Hall state and investigate collective excitations both edge bulk via photoluminescence spectral energy shifts. Introducing an offset significantly enhances excitation signal. Real-space time-resolved measurements reveal dynamics excitations, with estimated group velocity approximately $3 \times 10^4$ m/s. These align well magneto-plasmon model. Our...
This paper reviews the historical development and current research trends in both global domestic authentic leadership. Authentic leadership began as a challenging task to address issues caused by capital market oriented leaders. emphasizes authenticity of purpose compassion leaders carry rectify detrimental effects While existing styles skills necessary conditions for leadership, features sufficient The also introduces theory Korea discusses future prospects with aim contributing overcoming...
Loop-mediated isothermal amplification (LAMP) is a nucleic acid method that allows the simple, quick, and low-cost detection of various viral genes. LAMP assays are susceptible to generating non-specific amplicons, as high concentrations DNA primers can give rise primer dimerization mismatched hybridizations, resulting in false-positive signals. Herein, we reported poly(ethylene glycol)-engrafted nanosized graphene oxide (PEG-nGO) significantly enhance specificity LAMP, owing its ability...
Hepatitis C virus (HCV) infection is responsible for various chronic inflammatory liver diseases. Here, we have identified a naturally occurring compound with anti-HCV activity and elucidated its mode of antiviral action.
Rather than the internal genome nucleic acids, biomolecules on surface of influenza virus itself should be detected for a more exact and rapid point-of-care yes/no decision virus-induced infectious diseases. This work demonstrates ultrasensitive electrical detection HA1 domain hemagglutinin (HA), representative viral protein virus, using top-down complementary metal oxide semiconductor (CMOS) processed silicon nanowire (SiNW) field-effect transistor (FET) configuration....
Helicases are motor enzymes that convert the chemical energy of NTP hydrolysis into mechanical force for motion and nucleic acid strand separation. Within cell, helicases process a range sequences. It is not known whether this composite rate moving opening strands acids depends on base sequence. Our presteady state kinetic studies from two classes, ring-shaped T7 helicase forms non-ring-shaped hepatitis C virus (HCV) helicase, show both unwinding processivity depend sequence decrease as...
Complementary Si nanowire (SiNW) hydrogen ion sensors with high sensitivity and robust voltage output are demonstrated on a 6-in silicon-on-insulator wafer using conventional wafer-level top-down process. The proposed SiNW exhibit logic threshold shift of 88.9 mV/pH an swing 162 mV/pH. Furthermore, simplified analytical model confirms that the have is 1.6 times larger than single sensor counterparts resistive load. Therefore, fabrication approach expected to be good solution for very...
Surface protein hemagglutinin (HA) mediates the binding of influenza virus to host cell receptors containing sialic acid, facilitating entry into cells. Therefore, HA is regarded as a suitable target for development detection devices. In this study, we isolated single-stranded DNA (ssDNA) aptamers HA1 subunit subtype H1 (H1-HA1), but not H5 (H5-HA1), using counter-systematic evolution ligands by exponential enrichment (counter-SELEX) procedure. Enzyme-linked immunosorbent assay and surface...
Abstract Novel bio-/organic-inorganic hybrid compounds of deoxyribonucleic acid (DNA) and methotrexate (MTX)-layered double hydroxide are prepared by ion-exchange type intercalation reaction. The layered inorganic support. Mg2Al(NO3)-LDH, is at first obtained coprecipitation in an aqueous solution, then the interlayer NO3 − anions replaced guest molecules such as (an anticancer drug) (about 500 ∼ 1000 base pairs), leading to form new bio-/organic-nanohybrids. Upon intercalating into layers,...
We have discovered a novel chemical compound, (E)-3-(furan-2-yl)-N-(4-sulfamoylphenyl) acrylamide, that suppresses the enzymatic activities of SARS coronavirus helicase. To determine inhibitory effect, ATP hydrolysis and double-stranded DNA unwinding assays were performed in presence various concentrations compound. Through these assays, we obtained IC50 values 2.09 ± 0.30 µM (ATP hydrolysis) 13.2 0.9 (DNA unwinding), respectively. Moreover, found compound did not any significant...
Phage T7 helicase unwinds double-stranded DNA (dsDNA) by encircling one strand while excluding the complementary from its central channel. When translocates on single-stranded (ssDNA), it has kilobase processivity; yet, is unable to processively unwind linear dsDNA, even 60 base-pairs long. Particularly, GC-rich dsDNAs are unwound with lower amplitudes under single-turnover conditions. Here, we provide evidence that switches ssDNA dsDNA during unwinding. The switching propensity higher when...
The rechargeable Zn-air battery is considered as one of the potential candidates for next generation secondary batteries due to its many advantages. However, further applications and commercialization have been limited by complexity reactions on air electrode which are oxygen reduction evolution (ORR/OER) upon discharging charging processes, respectively. In present study, lanthanum was impregnated into a commercial Pt/C gas diffusion electrode, it clearly verified significantly enhanced...