A5006490928- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Mass Spectrometry Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Chronic Myeloid Leukemia Treatments
- Tea Polyphenols and Effects
- Sepsis Diagnosis and Treatment
- Biosensors and Analytical Detection
- Glycosylation and Glycoproteins Research
- Pharmacological Effects and Assays
- Antibiotics Pharmacokinetics and Efficacy
- Molecular Junctions and Nanostructures
- Monoclonal and Polyclonal Antibodies Research
- Antimicrobial Resistance in Staphylococcus
- Analytical Chemistry and Chromatography
- Hemodynamic Monitoring and Therapy
- Polymer Surface Interaction Studies
- RNA and protein synthesis mechanisms
- Metabolomics and Mass Spectrometry Studies
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Tannin, Tannase and Anticancer Activities
- Supercapacitor Materials and Fabrication
- Cynara cardunculus studies
Kyung Hee University
2010-2024
Kyung Hee University Hospital at Gangdong
2012-2023
Graduate School USA
2019
Seoul Institute
2015-2018
Government of the Republic of Korea
2015-2018
Kyung Hee University Dental Hospital
2018
Kyung Hee University Medical Center
2016
Kyung Hee University East-West Neo Medical Center
2010-2011
Korea University
2008-2009
University Medical Center Freiburg
2009
<b><i>Objective:</i></b> Until now, cutoff values of low skeletal muscle mass using computed tomography (CT) were driven by optimal stratification to predict mortality in cancer patients. The aim the present study was investigate simple, age-specific, value CT healthy adults. <b><i>Design:</i></b> This is a retrospective, observational, single-center study. <b><i>Setting:</i></b> performed health screening department...
We report a simple fluorometric method for detection of single-nucleotide changes in RNA using graphene oxide (GO) and RNA-cleaving DNAzyme.
We have discovered a novel chemical compound, (E)-3-(furan-2-yl)-N-(4-sulfamoylphenyl) acrylamide, that suppresses the enzymatic activities of SARS coronavirus helicase. To determine inhibitory effect, ATP hydrolysis and double-stranded DNA unwinding assays were performed in presence various concentrations compound. Through these assays, we obtained IC50 values 2.09 ± 0.30 µM (ATP hydrolysis) 13.2 0.9 (DNA unwinding), respectively. Moreover, found compound did not any significant...
<b><i>Background/Aims:</i></b> Muscle mass depletion has been suggested to predict morbidity and mortality in various diseases. However, it is not well known whether muscle associated with poor outcome sepsis. We hypothesized that <b><i>Methods:</i></b> Retrospective observational study was conducted an emergency department during a 9-year period. Medical records of 627 patients sepsis were reviewed. divided the into 2 groups according 28-day...
A readily synthesizable fluorescent probe DMAT-π-CAP was evaluated for sensitive and selective detection of human serum albumin (HSA). showed turn-on fluorescence at 730 nm in the presence HSA with more than 720-fold enhancement emission intensity ([DMAT-π-CAP] = 10 μM), rapid accomplished 3 s. The shown to increase concentration-dependent manner (Kd 15.4 ± 3.3 limit determined be 10.9 nM (0.72 mg/L). 1:1 stoichiometry between determined, displacement assay revealed that competes hemin...
The Bcr/Abl chimeric protein was captured by two antibodies, anti-Bcr on gold nanoparticles (AuNPs) and anti-Abl a biochip, in sandwich assay format. presence of the cells then verified amplified LDI-TOF MS signals, relative amounts were quantified using AuNPs coated with deuterated alkanethiols as an internal standard.
(-)-Epigallocatechin-3-gallate (EGCG) is known as a mitochondria-targeted molecule that can prevent mitochondrial deterioration and induce biogenesis by modulating key regulators of metabolism. In this study, we tackled whether derivatization EGCG could result in enhancement its effects on biogenesis. EGCG, peracetate (AcEGCG), 4″- O-alkyl substituted congeners prepared previously reported procedures were biologically evaluated. Interestingly, AcEGCG only marginally effective inducing...
Mutations in epidermal growth factor receptor (EGFR) are known as biomarkers that cause non-small cell lung cancer. Particularly, approximately 45% of cancer patients possess a deletion exon 19 the EGFR gene. A less invasive method for detecting mutation is required; thus, we developed simple polymerase chain reaction (PCR)-based by using quencher-free fluorescent probe DNA and graphene oxide (GO). In presence mutation, fluorophore-labeled was designed to be fully complementary mutant...
Urokinase plasminogen activator (uPA) and its inhibitor inhibitor‐1 (PAI‐1) are established independent biomarkers for high metastasis risk in breast cancer. In this study, we investigated the regulatory activity of (−)‐epigallocatechin‐3‐gallate (EGCG) derivatives on uPA PAI‐1 expression thereby their anti‐metastatic potential. EGCG showed only marginal effects system metastatic behavior cancer cells (MDA‐MB‐231). However, derivative 3e with a methyl‐substituted carbonate substituent at...
Triazolium cyclodextrin click cluster (+CCC) is an ideal scaffold to specifically bind phosphoinositides (PIPs) via multivalent electrostatic interaction. A new enrichment material, triazolium cluster-magnetic agarose bead conjugate (+CCC-MAB), was synthesized and applied the PIP of brain tissue. The enriched sample analyzed using MALDI-TOF MS in negative ion mode without any derivatization. extract tissue known contain abundant lipid interferences. By employing magnetic pull-down separation...
The authors report a case of bladder fistula associated with medial thigh cutaneous and chronic osteomyelitis the pubic bone 11 years after surgery for pelvic fracture rupture. In presenting case, despite clinical suspicion, none diagnostic tools demonstrated preoperatively. This suggests that repair should be prepared, even if cannot confirmed by imaging studies because amount urine leakage can minimal or close spontaneously.
This study demonstrated that human urine can be derivatized in a simple manner and the proposed method suitable for routine noninvasive evaluation of oxidative stress. A rapid sensitive determination malondialdehyde (MDA) concentrations has been developed using high-performance liquid chromatography. The MDA concentration pooled samples was determined after its conversion with 2,4-dinitrophenylhydrazine (DNPH) to hydrazone (MDA-DNPH). MDA-DNPH separated on C18 column quantified by diode...
Background:The prevalence and prognostic value of overt disseminated intravascular coagulation (DIC) in patients with septic shock presenting to emergency departments (EDs) is poorly understood, particularly following the release a new definition shock.The purpose this study was investigate DIC shock.Methods: We performed retrospective review 391 consecutive admitting ED tertiary care, university-affiliated hospital during 16-month.Septic defined as fluid-unresponsive hypotension requiring...
Intimately mixed nanocomposite of Fe2O3 and Mn3O4 is synthesized by an electrostatically-derived self-assembly between exfoliated MnO2 nanosheets Fe cations, which followed heat-treatment at elevated temperature. The as-prepared Fe–layered experiences phase transformations into Fe-substituted Mn3−xFexO4 nanoparticle 450 °C Fe2O3–Mn3O4 650 °C. Fe2O3−Mn3O4 shows better performance as anode material for lithium ion batteries than the nanoparticle, indicating beneficial effect composite...