A5064864689- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Long-Term Effects of COVID-19
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Intensive Care Unit Cognitive Disorders
- Multiple Sclerosis Research Studies
- Glycogen Storage Diseases and Myoclonus
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrovascular and genetic disorders
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Glioma Diagnosis and Treatment
- RNA regulation and disease
- Cell Image Analysis Techniques
- Neurological and metabolic disorders
- Restless Legs Syndrome Research
- Peripheral Neuropathies and Disorders
- History of Medicine Studies
- Paleopathology and ancient diseases
Mayo Clinic
2022-2025
WinnMed
2022-2024
Mayo Clinic in Arizona
2021-2024
Neurology, Inc
2022-2023
Mayo Clinic in Florida
2023
Fondazione Golgi Cenci
2018-2022
University of Pavia
2019
Delirium may be one of the presenting symptoms COVID-19, complicating diagnosis and care elderly patients with dementia. We aim to identify prevalence prognostic significance delirium as sole onset manifestation COVID-19.This is a retrospective single-centre study based on review medical charts, conducted during outbreak peak (March 27-April 18, 2020) in Lombard dementia facility, including 59 subjects laboratory-confirmed COVID-19.Of residents, 57 (96⋅6%) tested positive (mean age: 82⋅8;...
The actual role of SARS-CoV-2 in brain damage remains controversial due to lack matched controls. We aim highlight what extent is neuropathology determined by or pre-existing conditions. Findings 9 Coronavirus disease 2019 (COVID-19) cases and 6 non-COVID controls (mean age 79 y/o) were compared. Brains analyzed through immunohistochemistry detect SARS-CoV-2, lymphocytes, astrocytes, endothelium, microglia. A semi-quantitative scoring was applied grade microglial activation. Thal-Braak...
Posterior cortical atrophy (PCA) and dementia with Lewy bodies (DLB) show distinct overlapping hypometabolism profiles, but it is unknown how disruptions in structural functional connectivity compare between these disorders whether breakdowns relate to either or hypometabolism. Thirty amyloid-positive PCA patients, 24 amyloid-negative DLB patients 30 cognitively unimpaired (CU) healthy individuals were recruited at Mayo Clinic, Rochester, MN, underwent a 3T head MRI, including resting state...
Few studies have examined lockdown effects on the way of living and well-being older adults stratified by cognitive state. Since deficits are common in this population, we investigated how cognition influenced their understanding pandemic, socio-behavioral responses lifestyle adaptations during lockdown, these factors affected mood or memory.Telephone-based survey involving 204 ≥65 y/o (median: 82) with previous assessments state: 164 normal-old (NOLD), 24 mild-neurocognitive disorder...
Abstract INTRODUCTION Greater white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) are seen with transactive response DNA‐binding protein 43 (TDP‐43) pathology in frontotemporal lobar degeneration (FTLD‐TDP). WMH associations TDP‐43 Alzheimer's disease (AD‐TDP) remain unclear. METHODS A total of 157 participants from Mayo Clinic Rochester autopsy‐confirmed AD, known status, and antemortem fluid‐attenuated inversion recovery (FLAIR) MRI were included. Vascular risk factors...
Abstract Our current knowledge of the structure, function, and diseases brain comes from direct examination its substance. In last centuries, only a few elite had managed to retrieve, gather, preserve elusive for their own research. The resulting collections, stored in formalin‐filled jars or dried up cabinets, served anatomical, neuropathological, anthropometric, ideological, diagnostic purposes. 1960s, first modern banks actively collecting strategically preserving both diseased healthy...
Here, we aim to describe COVID-19 pathology across different tissues clarify the disease’s pathophysiology. Lungs, kidneys, hearts, and brains from nine autopsies were compared by using antibodies against SARS-CoV-2, macrophages-microglia, T-lymphocytes, B-lymphocytes, activated platelets. Alzheimer’s Disease was also assessed. PCR techniques used verify presence of viral RNA. cases had a short clinical course (0–32 days) their mean age 77.4 y/o. Hypoxic changes inflammatory infiltrates...
Flortaucipir (FTP) PET is a key imaging technique to evaluate tau burden indirectly. However, it appears have greater utility for 3R+4R found in Alzheimer's disease (AD), compared other non-AD tauopathies. The purpose of this study determine how flortaucipir uptake links neuropathologically determined AD and We identified nine individuals who had undergone antemortem tau-PET postmortem neuropathological analyses. cohort included three patients with low, moderate, high neuropathologic changes...
Atypical variants of Alzheimer's disease (AD) include the visual variant, known as posterior cortical atrophy (PCA), and language logopenic progressive aphasia (LPA). Clinically, rates progression differ between them.
In a constantly aging population, the prevalence of neurodegenerative disorders is expected to rise. Understanding disease mechanisms key find preventive and curative measures. The most effective way achieve this through direct examination diseased healthy brain tissue. authors present protocol obtain, process, characterize store good quality tissue donated by individuals registered in an antemortem donation program. program includes face-to-face empathic approach people, collection...
Primary four-repeat tauopathies are characterized by depositions of the isoform microtubule binding protein, tau. The two most common sporadic progressive supranuclear palsy and corticobasal degeneration. Because tau PET tracers exhibit poor affinity to pathology, determining how well in vivo MRI findings relate underlying pathology is critical evaluating their utility as surrogate markers aid diagnosis outcome measures for clinical trials. We studied relationship cross-sectional imaging...
Alzheimer's disease (AD) patients ≥70 years show smaller medial temporal volumes despite less
Background: Increasing evidence suggests that TAR DNA-binding protein 43 (TDP-43) pathology in Alzheimer’s disease (AD), or AD-TDP, can be diffuse limbic-predominant. Understanding whether AD-TDP has genetic, clinical, and pathological features differ from limbic could have clinical research implications. Objective: To better characterize the pathologic of differentiate it AD-TDP. Methods: 363 participants Mayo Clinic Study Aging, Disease Research Center, Neurodegenerative Group with autopsy...
Abstract Progressive supranuclear palsy is a neurodegenerative disease characterized by the deposition of four-repeat tau in neuronal and glial lesions brainstem, cerebellar, subcortical cortical brain regions. There are varying clinical presentations progressive with different neuroimaging signatures, presumed to be due topographical distributions burden tau. The classic Richardson syndrome presentation considered variant, whilst predominant speech language impairment although pathological...
Abstract Transactive response DNA-binding protein 43 (TDP-43) pathology is categorized as type A-E in frontotemporal lobar degeneration and α-β Alzheimer disease (AD) based on inclusion type. We screened amygdala slides of 131 cases with varying ages at death, clinical/neuroimaging findings, AD neuropathologic changes for TDP-43 using anti-phospho-TDP-43 antibodies. Seven (5%) only showed atypical inclusions that could not be typed. Immunohistochemistry immunofluorescence assessed the...
Abstract Disruption of the default mode network is a hallmark Alzheimer’s disease, which has not been extensively examined in atypical phenotypes. We investigated cross-sectional and 1-year longitudinal changes sub-systems visual language variants relation to age tau. Sixty-one amyloid-positive disease participants diagnosed with posterior cortical atrophy (n = 33) or logopenic progressive aphasia 28) underwent structural MRI, resting-state functional MRI [18F]flortaucipir PET. One-hundred...
In a constantly aging population, the prevalence of neurodegenerative disorders is expected to rise. Understanding disease mechanisms key find preventive and curative measures. The most effective way achieve this through direct examination diseased healthy brain tissue. authors present protocol obtain, process, characterize store good quality tissue donated by individuals registered in an antemortem donation program. program includes face-to-face empathic approach people, collection...
Abstract Background The language and visual variants are two common clinical phenotypes of atypical Alzheimer’s disease (AD). There reports overlap between these phenotypes, however, the extent frequency overlap, its neuroanatomical underpinnings remain unclear. Method Eighty‐two patients with biomarker‐confirmed AD who presented either predominant (n = 34) or visuospatial/perceptual 48) deficits were recruited by Neurodegenerative Research Group underwent neurological neuropsychological...
Transactive response DNA‐binding protein 43 (TDP‐43) pathological inclusions are found in frontotemporal lobar degeneration (FTLD‐TDP) and Alzheimer's disease (AD‐TDP). While clinically different, TDP‐43 FTLD‐TDP AD can have similar morphological characteristics. However, colocalizing with tau forming “apple‐bite” or “flame‐shaped” neuronal cytoplasmic (NCI) only AD‐TDP. Here, we describe a case neuritic plaque‐associated TDP‐43. The patient was 96‐year‐old right‐handed Caucasian woman who...