A5039219723- Market Dynamics and Volatility
- MicroRNA in disease regulation
- Monetary Policy and Economic Impact
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA regulation and disease
- Sperm and Testicular Function
- Financial Risk and Volatility Modeling
- Amyotrophic Lateral Sclerosis Research
- Reproductive Biology and Fertility
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Global Energy and Sustainability Research
- RNA Research and Splicing
- Air Quality and Health Impacts
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Climate Change and Health Impacts
- Muscle Physiology and Disorders
- Energy and Environment Impacts
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Xenotransplantation and immune response
- Electric Power System Optimization
- GDF15 and Related Biomarkers
University of Trento
2014-2024
Enel (Italy)
2010-2012
Sapienza University of Rome
1998-2011
University College London
2003-2010
Istituto Pasteur
2009
Istituto Superiore di Sanità
2006-2007
Bocconi University
2006
Fondazione Eni Enrico Mattei
2003-2005
Spermatogenesis is maintained by a pool of spermatogonial stem cells (SSCs). Analyses the molecular profile SSCs have revealed existence subsets, indicating that cell population more heterogeneous than previously believed. However, SSC subsets are poorly characterized. In rodents, first steps in spermatogenesis been extensively investigated, both under physiological conditions and during regenerative phase follows germ damage. widely accepted model, type Asingle (As) spermatogonia. Here, we...
In mice and other mammals, spermatogenesis is maintained by spermatogonial stem cells (SSCs), a cell population belonging to undifferentiated type A spermatogonia. the accepted model of SSC self-renewal, Asingle (As) spermatogonia are cells, whereas paired (Apaired (Apr)) chained (Aaligned (Aal)) committed differentiation. This has been recently challenged evidence that As (Apr Aal), heterogeneous in terms gene expression function. The profile several markers, such as GFRA1 (the GDNF...
MicroRNAs (miRNAs) are emerging as key regulators of complex biological processes in several cardiovascular diseases, including atrial fibrillation (AF). Reverse transcription-quantitative polymerase chain reaction is a powerful technique to quantitatively assess miRNA expression profile, but reliable results depend on proper data normalization by suitable reference genes. Despite the increasing number studies assessing miRNAs cardiac disease, no consensus best genes has been reached. This...
Given the heterogeneous nature of frontotemporal dementia (FTD), sensitive biomarkers are greatly needed for accurate diagnosis this neurodegenerative disorder. Circulating miRNAs have been reported as promising disorders and processes affecting central nervous system, especially in aging. The objective study was to evaluate if some circulating linked with apoptosis (miR-29b-3p, miR-34a-5p, miR-16-5p, miR-17-5p, miR-107, miR-19b-3p, let-7b-5p, miR-26b-5p, 127-3p) were able distinguish...
In mammals, the biological activity of stem/progenitor compartment sustains production mature gametes through spermatogenesis. Spermatogonial stem cells and their progeny belong to class undifferentiated spermatogonia, a germ cell population found on basal membrane seminiferous tubules. A large body evidence has demonstrated that glial line-derived neurotrophic factor (GDNF), Sertoli-derived factor, is essential for in vivo vitro self-renewal. However, mechanisms underlying this are not...
Abiraterone acetate (AA) serves as a medication for managing persistent testosterone production in patients with metastatic castration-resistant prostate cancer (mCRPC). However, its efficacy varies among individuals; thus, the identification of biomarkers to predict and follow treatment response is required. In this pilot study, we explored potential circulating microRNAs (c-miRNAs) stratify based on their responsiveness AA. We conducted an analysis plasma samples obtained from cohort 33...
Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including brain, where it localizes in neurons and activated microglia. Loss-of-function mutations GRN gene are an important cause of familial Frontotemporal Lobar Degeneration (FTLD). PGRN has neurotrophic anti-inflammatory activity, neuroprotective several injury conditions, such as oxygen or glucose deprivation, oxidative injury, hypoxic stress. Indeed, we have previously demonstrated that hypoxia induces...
This paper estimates the dynamic conditional correlations in returns on Tapis oil spot and one-month forward prices for period 2 June 1992 to 16 January 2004, using recently developed multivariate volatility models, namely Constant Conditional Correlation Multivariate GARCH (CCC–MGARCH) model of Bollerslev (1990 Bollerslev, T. 1990. Modelling coherence short-run nominal exchange rates: a generalized ARCH approach. Review Economics Statistics, 72: 498–505. [Crossref], [Web Science ®] ,...
Atrial stretch and dilatation are common features of many clinical conditions predisposing to atrial fibrillation (AF). MicroRNAs (miRs) emerging as potential molecular determinants AF, but their relationship with is poorly understood. The present study was designed assess the specific miR expression profiles associated in human tissue. expressions a preselected panel miRs, previously described playing role cardiac disease, were quantified by reverse transcription-quantitative polymerase...
Epithelial-to-mesenchymal transition (EMT) is involved in prostate cancer (PCa) metastatic progression, and its plasticity suggests epigenetic implications. Deregulation of DNA methyltransferases (DNMTs) several microRNAs (miRNAs) plays a relevant role EMT, but their interplay has not been clarified yet. In this study, we provide evidence that DNMT3A interaction with miRNAs central an ex vivo EMT PCa model obtained via exposure PC3 cells to conditioned media from cancer-associated...
The existing literature on price asymmetries does not systematically investigate the sensitivity of empirical results to choice a particular econometric specification. This paper fills this gap by providing detailed comparison three most popular models designed describe asymmetric behaviour, namely ECM, autoregressive threshold ECM and with cointegration. Each model is estimated common monthly dataset for gasoline markets France, Germany, Italy, Spain UK over period 1985-2003. All are able...
Dementia is one of the most common diseases in elderly people and hundreds thousand new cases per year Alzheimer's disease (AD) are estimated. While recent decade has seen significant advances development novel biomarkers to identify dementias at their early stage, a great effort been recently made able improve differential diagnosis. However, only few potential candidates, mainly detectable cerebrospinal fluid (CSF), have described so far. We searched for miRNAs regulating MAPT translation....
Abstract The dystrobrevins (α and β) are components of the dystrophin‐associated protein complex (DPC), which links cytoskeleton to extracellular matrix serves as a scaffold for signaling proteins. precise functions β‐dystrobrevin isoform, is expressed in nonmuscle tissues, have not yet been determined. To gain further insights into role brain, we performed yeast two‐hybrid screen identified pancortin‐2 novel β‐dystrobrevin‐binding partner. Pancortins‐1–4 neuron‐specific olfactomedin‐related...
Lung cancer is still one of the leading cause death worldwide. The clinical variability lung high and drives treatment decision. In this context, correct discrimination pulmonary neuroendocrine tumors critical relevance. spectrum various, each type has molecular phenotypical differences. order to advance in from non-neuroendocrine tumors, we tested a series 95 surgically resected formalin-fixed paraffin embedded tissues, analyzed expression miR205-5p miR375-3p via TaqMan RT-qPCR. Via robust...