A5066525792- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Cystic Fibrosis Research Advances
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Toxoplasma gondii Research Studies
- Polyomavirus and related diseases
- HIV-related health complications and treatments
- Parasites and Host Interactions
- Viral Infections and Immunology Research
- COVID-19 and Mental Health
- COVID-19 Impact on Reproduction
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Food Allergy and Anaphylaxis Research
- Mycobacterium research and diagnosis
- Pregnancy and Medication Impact
- Respiratory viral infections research
Azienda Ospedaliero-Universitaria Careggi
2012-2024
Regione Toscana
2024
National Centre for Disease Prevention and Control
2023
University of Florence
2020-2022
Meyer Children's Hospital
2022
Università Cattolica del Sacro Cuore
2014
Catholic University of America
2013
During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches be needed. We present case of 36-year-old kidney-transplanted woman affected by Senior-Loken syndrome diagnosed with COVID-19 pneumonia after contact her positive mother. Initial symptoms were fatigue, dry cough, coryza; she never had...
<h3>Importance</h3> Convalescent plasma (CP) has been generally unsuccessful in preventing worsening of respiratory failure or death hospitalized patients with COVID-19 pneumonia. <h3>Objective</h3> To evaluate the efficacy CP plus standard therapy (ST) vs ST alone <h3>Design, Setting, and Participants</h3> This prospective, open-label, randomized clinical trial enrolled (1:1 ratio) pneumonia to receive between July 15 December 8, 2020, at 27 sites Italy. Hospitalized adults a partial...
COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as “long-COVID” or “post-COVID-19” syndrome. Despite an increasing body literature, long COVID remains poorly characterized. We retrospectively analysed data from electronic medical records patients admitted the post-COVID-19 outpatient service Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 2021, 4–12 weeks after hospital discharge. A total 428...
We analysed the first 84 coronavirus disease (COVID-19) patients hospitalised in an infectious and tropical unit Florence, Italy, over 30 days after start of COVID-19 outbreak Italy. A 12% reduction rate intensive care transfer was observed implementation intensity measures regular ward such as increasing nurse/patient ratio, presence critical physicians using high flow nasal cannulae oxygenation.
aligning with prior publications. 8,9Conversely, Manesh et al. 10 found that crushed posaconazole DR tablets given per feeding tube at a dose of 300 mg daily produced therapeutic levels after 2 weeks therapy in 19 patients receiving treatment for rhino-orbito-cerebral mucormycosis. 10any factors can impact drug tablets, spanning from the obvious patient (i.e.absorption) to terminal placement (e.g.J-tube versus G-tube) or more nuanced (preparation and administration technique).The literature...
A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, prolonged viral shedding. Our case report supports the hypothesis that an effective response may be dispensable for control of progression to forms, while it necessary SARS-CoV-2 clearance. We a 26-year-old woman, clinical history epilepsy since age eight, who was diagnosed coronavirus disease 2019 (COVID-19) by reverse-transcriptase–polymerase-chain-reaction (RT-PCR) on nasopharyngeal swab...
Abstract More than 11.5 billion COVID-19 vaccine doses have been administered around the world. Although effectiveness for severe infections is reported to be 89.0%, breakthrough are common and may lead outcome in fragile population. We conducted a real-world observational study on 420 admitted patients from July 2021 January 2022 tertiary level Italian hospital. collected patient’s vaccination SARS-CoV-2 serological status, treatments, oxygen supports, intensive (ICU) subintensive (sub-ICU)...
Abstract We evaluated 100 postacute coronavirus disease 2019 (COVID-19) patients a median (interquartile range) of 60 (48–67) days after discharge from the Careggi University Hospital, Italy. Eighty-four (84%) had at least 1 persistent symptom, irrespective COVID-19 severity. A considerable number hospital readmissions (10%) and/or infectious diseases (14%) during postdischarge period were reported.
Pregnant and postpartum women are at increased risk of developing severe COVID-19. Monoclonal antibodies (mAbs) now widely used in high-income countries to treat mild moderate COVID-19 outpatients for disease. Very few data available on the use mAbs special populations, including pregnant women. Here we present our early experience with these two populations.Electronic records treated Careggi University Hospital, Florence, were retrieved. Relevant extracted (age, presence factors COVID-19,...
Background: COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as "long-COVID" or "post-COVID" syndrome. Despite an increasing body literature, long COVID remains poorly characterized.Methods: We retrospectively analysed data from electronic medical records patients admitted the post-COVID outpatient service at Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 2021, 4-12 weeks after hospital...
Atazanavir and lopinavir represent the main HIV protease inhibitors recommended in pregnancy, but comparative data pregnant women are limited.Women from a national observational study, exposed pregnancy to either atazanavir or lopinavir, were compared for glucose lipid profiles, liver function tests, CD4 count, RNA outcomes. Statistical methods included univariate multivariable analyses.The study population 428 pregnancies (lopinavir, 322; atazanavir, 106). The group was characterized by...
To develop and assess the GAIA! app, designed to assist pregnant women healthcare professionals in managing infectious diseases during pregnancy, bridge information gap between health expectant mothers.
Objective: To estimate the epidemiological impact of syphilis in pregnancy and congenital Tuscany to better delineate their determinants this region. Methods: Features pregnant women with attending Reference Center for Infectious Diseases Pregnancy between 2000 2010 infants were retrospectively reviewed. Results: One hundred eighty-seven pregnancies observed. The number evaluated increased steadily from 24 2000–2002 70 2009–2010. majority Italian (20.32%) East European (44.39%). Eight cases...
The aim of this study was to evaluate immunoglobulin M indirect-fluorescent antibody test (IgM IFAT) for the diagnosis acute or chronic Toxoplasma infection in pregnancy.Pregnant women with suspected toxoplasmosis referred Tuscany Reference Center Infectious Diseases Pregnancy during period 1998-2012 were retrospectively enrolled. All tested a panel serological tests, including enzyme-linked immunosorbent assay IgG avidity and IgM IFAT. On basis anamnestic, clinical, criteria, pregnant...
Valacyclovir is currently the only pharmacological intervention demonstrated to reduce risk of vertical CMV congenital infection within a randomized clinical trial in case primary during pregnancy.So far, no data are available on prognosis children with diagnosed at birth after negative amniocentesis whose mother were treated valacyclovir pregnancy, therefore it essential carry out rigorous neurocognitive follow-up these order investigate potential consequence.