A5091430589- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Fungal Infections and Studies
- Cystic Fibrosis Research Advances
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Autoimmune and Inflammatory Disorders Research
- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- COVID-19 and healthcare impacts
- Immune responses and vaccinations
- Respiratory viral infections research
- Infectious Encephalopathies and Encephalitis
- Immune Cell Function and Interaction
- Antenna Design and Analysis
- Nematode management and characterization studies
- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 detection and testing
- Travel-related health issues
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
Azienda Ospedaliero-Universitaria Careggi
2019-2024
University of Florence
2012-2023
Hospital for Tropical Diseases
2020
Ospedale Cisanello
2010
BACKGROUND. Coronavirus disease 19 (COVID-19) is an emerging infectious caused by SARS-CoV-2. Antiviral immune response crucial to achieve pathogen clearance; however, in some patients excessive and aberrant host can lead acute respiratory distress syndrome. The comprehension of the mechanisms that regulate elimination, immunity, pathology essential better characterize progression widen spectrum therapeutic options.
COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as “long-COVID” or “post-COVID-19” syndrome. Despite an increasing body literature, long COVID remains poorly characterized. We retrospectively analysed data from electronic medical records patients admitted the post-COVID-19 outpatient service Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 2021, 4–12 weeks after hospital discharge. A total 428...
The characterization of cell-mediated and humoral adaptive immune responses to SARS-CoV-2 is fundamental understand COVID-19 progression the development immunological memory virus. In this study, we detected T-cells reactive proteins M, S, N, as well serum virus-specific IgM, IgA, IgG, in nearly all infected individuals, but not healthy donors. Virus-reactive T cells exhibited signs vivo activation, suggested by surface expression immune-checkpoint molecules PD1 TIGIT. Of note,...
We analysed the first 84 coronavirus disease (COVID-19) patients hospitalised in an infectious and tropical unit Florence, Italy, over 30 days after start of COVID-19 outbreak Italy. A 12% reduction rate intensive care transfer was observed implementation intensity measures regular ward such as increasing nurse/patient ratio, presence critical physicians using high flow nasal cannulae oxygenation.
Abstract Background and Purpose Waning immunity the surge of SARS-CoV-2 variants are responsible for breakthrough infections, i.e., infections in fully vaccinated individuals. Although majority infected subjects report mild or no symptoms, some others require hospitalization. The clinical immunological features hospitalized COVID-19 patients currently unknown. Methods Twenty-nine unvaccinated 36 were prospectively enrolled laboratory data gathered. Immunophenotyping leukocytes’ subsets, T B...
Hemophagocytic lymphohistiocytosis (HLH) is a serious haematologic condition that can be related to various diseases, including tuberculosis (TB). The patient previously healthy 26-year-old man, originally from western Africa, admitted hospital for fever and weight loss. Given the results of computed tomography (CT) scan, ocular examination microbiologic tests, miliary TB with pulmonary, lymph nodal involvement was diagnosed. Following introduction antitubercular treatment (ATT), an increase...
ObjectivesHigh accuracy diagnostic screening tests for tuberculosis (TB) are required to improve the diagnosis of both active TB and latent Mycobacterium (MTB) infection (LTBI). The novel IGRA LIOFeron®TB/LTBI assay was tested its compared QuantiFERON®-TB Gold Plus assay.MethodsA total 389 subjects were enrolled in two cohorts classified as healthy, or LTBI persons. blood all patients with assay, containing MTB alanine dehydrogenase, able differentiate from diagnosis. results obtained IGRAs,...
The diseases caused by non-tuberculous mycobacteria (NTM), in both AIDS and non-AIDS populations, are increasingly recognized worldwide. Although the American Thoracic Society published guidelines for diagnosis of NTM pulmonary disease (NTM-PD), is still difficult. In first part study, we collected data on isolates Mycobacteriology Laboratory Careggi Hospital (Florence, Italy) analysed epidemiological isolates. Then, to analyse risk factors associated NTM-PD, studied presence ATS/IDSA...
Abstract More than 11.5 billion COVID-19 vaccine doses have been administered around the world. Although effectiveness for severe infections is reported to be 89.0%, breakthrough are common and may lead outcome in fragile population. We conducted a real-world observational study on 420 admitted patients from July 2021 January 2022 tertiary level Italian hospital. collected patient’s vaccination SARS-CoV-2 serological status, treatments, oxygen supports, intensive (ICU) subintensive (sub-ICU)...
Abstract We evaluated 100 postacute coronavirus disease 2019 (COVID-19) patients a median (interquartile range) of 60 (48–67) days after discharge from the Careggi University Hospital, Italy. Eighty-four (84%) had at least 1 persistent symptom, irrespective COVID-19 severity. A considerable number hospital readmissions (10%) and/or infectious diseases (14%) during postdischarge period were reported.
Background: COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as "long-COVID" or "post-COVID" syndrome. Despite an increasing body literature, long COVID remains poorly characterized.Methods: We retrospectively analysed data from electronic medical records patients admitted the post-COVID outpatient service at Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 2021, 4-12 weeks after hospital...
Nebulised therapy is the mainstay for treating obstructive airway diseases, but there heightened concern about potential risk SARS-CoV-2 transmission during nebulisation in COVID-19 patients. We investigated effects of 0.9% saline on RNA spreading 11 patients (5 females, mean age 62.45±9.31 yr). In 6 out we also ascertained whether changed number exhaled bioaeroosl particles. Air samples were collected using suction pumps equipped with 0.45μm PTFE filters and positioned around patient's bed....
Dengue fever (DF) is a leading travel-related illness worldwide. Outbreaks from imported cases occurred in Europe. Case detection serves both patient safety and public health interests origin destination countries. We report cluster of DF to Italy by travellers Sharm El-Sheik, highly touristic destination.
Hemophagocytic lymphohistiocytosis (HLH) is a serious haematologic condition that can be re-lated to various diseases, including tuberculosis (TB). The patient previously healthy 26-years-old man, originally from Western Africa, admitted hospital for fever and weight loss. Given the results of computed tomography (CT) scan, ocular examination microbiologic tests, miliary TB with pulmonary, lymph nodal involvement was diagnosed. Following introduction antitubercular treatment (ATT) an...