A5057752612- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Rabies epidemiology and control
- Toxoplasma gondii Research Studies
- Bacillus and Francisella bacterial research
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Diagnosis and treatment of tuberculosis
- Yersinia bacterium, plague, ectoparasites research
- Microbial infections and disease research
- Insect and Pesticide Research
- Virus-based gene therapy research
- Plant and animal studies
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Rheumatoid Arthritis Research and Therapies
- Fire effects on ecosystems
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Tuberculosis
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Virology and Viral Diseases
- Mycotoxins in Agriculture and Food
- Brucella: diagnosis, epidemiology, treatment
- Marine Biology and Environmental Chemistry
Kazan State Medical Academy
2017-2024
Russian Medical Academy of Continuous Professional Education
2017-2024
Kazan Federal University
2014-2022
Kazan State Academy of Veterinary Medicine named after N.E. Bauman
2020-2022
A.E. Arbuzov Institute of Organic and Physical Chemistry
2022
Kazan Scientific Center
2017-2021
Kazan State Medical University
2021
Federal Research Centre of Nutrition and Biotechnology
2015
Washington State University
2011
Bord na Móna (Ireland)
2008-2010
ABSTRACT Efforts to develop a better diagnostic assay for bovine tuberculosis have shown that the sensitivity and specificity of an can be improved by use two or more antigens. As reported here, we developed multiplex chemiluminescent immunoassay simultaneously detect antibody activity 25 antigens in single well 96-well plate array format. The signal is captured with digital imaging system analyzed macro program tracks each serum its pattern Mycobacterium bovis comparison sera from 522...
The clinical and immunological spectrum of acute post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) systemic lupus erythematosus (SLE). Indeed, following SARS-Cov2 infection, the innate immune response is altered an initial delayed production interferon type I (IFN-I), while NF-kappa B inflammasome pathways are activated. In lung digestive tissues, alternative extrafollicular against takes place with, consequently,...
Rapid, simple, and accurate antemortem tests for tuberculosis (TB) in cattle need to be developed order augment the existing screening methods. In particular, as vaccines are developed, such would allow continuation of test-and-slaughter policies alongside vaccination. Therefore, development an assay that distinguishes infected from vaccinated animals (a DIVA test) is urgent research requirement. this study, we assessed performance a novel multiplex serological test with sera collected 96...
ObjectivesHigh accuracy diagnostic screening tests for tuberculosis (TB) are required to improve the diagnosis of both active TB and latent Mycobacterium (MTB) infection (LTBI). The novel IGRA LIOFeron®TB/LTBI assay was tested its compared QuantiFERON®-TB Gold Plus assay.MethodsA total 389 subjects were enrolled in two cohorts classified as healthy, or LTBI persons. blood all patients with assay, containing MTB alanine dehydrogenase, able differentiate from diagnosis. results obtained IGRAs,...
Background Tuberculosis (TB) still is a major worldwide health problem, with 10.4 million new cases in 2016. Only 5–15% of people infected M. tuberculosis develop TB disease while others remain latently (LTBI) during their lifetime. Thus, the absence tests able to distinguish between latent infection and active one limits currently available diagnostic tools. Methods A total 215 patients were included study as (n = 73), LTBI subjects 88) healthy persons 54). Peripheral blood mononuclear...
The objective: to study factors that reduce the diagnostic efficiency of rapid testing for tuberculosis based on detection antibodies PstS1 and PstS3 antigens M. highly purified lipoglycan cell wall. Subjects Methods. Clinical laboratory data 290 patients were analyzed. Logistic regression analysis ROC used identify associated with a negative result testing. Results. 45/290 (16%) had positive test PstS1, 154/290 (53%) responded positively antigen. number people who tested was 164/290 (57%)....
Puumala orthohantavirus (PUUV) causes nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) commonly diagnosed in Europe. The majority HFRS cases the European part Russia are Volga Federal District, which includes Republic Tatarstan (RT). current study aims to analyze genetic variability PUUV Pre-Kama region RT bounded by Volga, Kama, and Vyatka rivers. In 2017, bank voles were caught seven isolated forest traps for 26 PUUV-positive samples, partial small...
Although the single intradermal comparative tuberculin skin test (SICTT) remains most effective assay for detecting cattle infected with Mycobacterium bovis, not all animals are detected SICTT. This has made it difficult to control bovine tuberculosis using a assay. Use of gamma interferon in conjunction SICTT improved level detection but some still go undetected. could be part attributable both assays being reliant on cell-mediated immune response. The present study was undertaken determine...
SUMMARY This report summarizes epidemiological data on nephropathia epidemica (NE) in the Republic of Tatarstan, Russia. NE cases identified period 1997–2013 were investigated parallel with hantavirus antigen prevalence small rodents study area. A total 13 930 documented all but one district most located central and southeastern districts. The annual incidence rate exhibited a cyclical pattern, highest numbers being registered once every 3–5 years. rose gradually from July to November,...
For clinicians, Pseudomonas aeruginosa is a nightmare pathogen that one of the top three causes opportunistic human infections. Therapy P. infections complicated due to its natural high intrinsic resistance antibiotics. Active efflux and decreased uptake drugs cell wall/membrane permeability appear be important issues in acquired antibiotic tolerance mechanisms. Bacterial wall biosynthesis enzymes have been shown essential for pathogenicity Gram-negative bacteria. However, role these targets...
The characterization of risk and protective factors in complex diseases such as rheumatoid arthritis (RA) has evolved from epidemiological studies, which test association, to the use Mendelian randomization approaches, direct relationships. Indeed, associations with mucosal origin RA are retrieved periodontal disease (Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans predominantly), interstitial lung involvement, tobacco smoking air pollutants. Next, directly associated an...
Background: Biological approach is becoming more popular in the protection of environment by organic waste agricultural holdings due to economic efficiency and absence additional damage ecosystem. Microorganisms biopreparations possess significant fermentative properties high antagonistic activity against many pathogenic opportunistic bacteria toxigenic filamentous fungi. In our study we have isolated millions coliform Enterococci, thousands Salmonella, Proteus Staphylococci 1 g initial...