A5023317709- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Complement system in diseases
- Acute Lymphoblastic Leukemia research
- Economic and Financial Impacts of Cancer
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Sexual function and dysfunction studies
- Renal Diseases and Glomerulopathies
- Long-Term Effects of COVID-19
- Vitamin D Research Studies
- COVID-19 and Mental Health
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Hormonal and reproductive studies
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Inflammasome and immune disorders
- Lymphoma Diagnosis and Treatment
- Blood properties and coagulation
- Salivary Gland Disorders and Functions
Azienda Socio Sanitaria Territoriale della Valtellina e Alto Lario
2016-2024
University of Catania
2023
Azienda Ospedaliera di Valtellina e Valchiavenna
2021
National Tsunami Warning Center
2021
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2010
BMT Group (United Kingdom)
2010
<h3>Importance</h3> Convalescent plasma (CP) has been generally unsuccessful in preventing worsening of respiratory failure or death hospitalized patients with COVID-19 pneumonia. <h3>Objective</h3> To evaluate the efficacy CP plus standard therapy (ST) vs ST alone <h3>Design, Setting, and Participants</h3> This prospective, open-label, randomized clinical trial enrolled (1:1 ratio) pneumonia to receive between July 15 December 8, 2020, at 27 sites Italy. Hospitalized adults a partial...
Thrombotic thrombocytopenic purpura (TTP) is a rare disorder characterized by thrombocytopenia, microangiopathic haemolytic anaemia, neurological and renal abnormalities fever1, with mortality rate, in the absence of treatment, almost 90%. Since such criteria do not distinguish TTP from uraemic syndrome (HUS), comprehensive term TTP-HUS more approriate2. The standard therapy urgent plasma exchange (PE)1, which reduces to 10% or less3–9. Because its dramatic effect on short long-term outcome,...
Jak inhibitors are potent anti-inflammatory drugs that have the potential to dampen hyperactive inflammatory response associated with severe COVID-19. We reviewed clinical outcomes of 218 patients COVID-19 hospitalized for pneumonia and treated ruxolitinib through a compassionate use program. Data on duration treatment; at 4, 7, 14, 28 days; oxygen support requirements; status; laboratory parameters were retrospectively collected. Overall, according physician evaluation, 66.5% showed...
T cell large granular lymphocytic (LGL) leukemia is a rare condition accounting for 2–3% of all mature lymphoid leukemias. Here, we present the case 73-year-old woman presenting with neutropenia and anemia (hemoglobin 9.9 g/dl). Hematological assessment revealed presence LGL leukemia. At time diagnosis, patient developed xerophthalmia xerostomia, diagnosis Sjögren’s syndrome was made following salivary gland biopsy. The finding lymphocytes in context autoimmune disorders well-known, though...
Introduction Up to 30% of CML patients will require a therapeutic change during follow-up, due intolerance and/or resistance first-line TKI approach. In this context, bosutinib (BOS) has not only demonstrated its effica-cy, but also presents favorable safety profile, without comorbid conditions representing an absolute contraindication use. Methods To gain further into BOS treatment in real-life, we conducted retrospective analysis on the outcome receiving 18 hematological centers, all...
Abstract Lombardy represents the largest region of Italy by population, with almost 10 million residents, a dimension similar to medium size country like Sweden or Belgium. The CML subcommittee Hematology Network (REL‐CML) conducted study at beginning 2023. Prevalence was calculated direct input from 21 centers participating in REL‐CML. Tyrosine Kinase Inhibitors (TKI) prescription records collected ARIA regional registry were used estimate number patients followed smaller not A total 2285...
Insufficient knowledge of primary immune thrombocytopenia purpura (ITP) in the elderly, together with a lack clinical trial data, has resulted wide variation treatments. Here, we present study focused on characteristics ITP older subjects at diagnosis integrated subsequent course disease and treatment history.In retrospective monoinstitutional study, evaluated >65-year-old patients ITP. Clinical time were described analyzed. We aimed to delineate whether lines therapy influenced number...
e18190 Background: When ASCO published Top Five List to improve cancer care in 2012, we applied the same principles build local guidelines, resulting first edition of our “Libro Blu” (Blue Book), named after a similar tool previously adopted by Swiss institution IOSI. In 2015 reform Lombardy public health, with establishment ASST-VAL, covering huge area 5 hospitals, brought further need for harmonization work; moreover, increasing appearance high cost drugs and simultaneous restrictions...