A5018924359- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Impact on Reproduction
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- Biosensors and Analytical Detection
- thermodynamics and calorimetric analyses
- Vibrio bacteria research studies
- Infections and bacterial resistance
- COVID-19 and healthcare impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Enterobacteriaceae and Cronobacter Research
- Bacterial biofilms and quorum sensing
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced biosensing and bioanalysis techniques
- Streptococcal Infections and Treatments
- Biochemical and Structural Characterization
- HIV/AIDS oral health manifestations
- DNA Repair Mechanisms
University of Florence
2017-2025
Don Carlo Gnocchi Foundation
2024-2025
Marconi University
2022-2025
Azienda Ospedaliero-Universitaria Careggi
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
University of Genoa
2022
Jackson and Tull (United States)
2022
Kindai University
2022
How is the semen quality of sexually active men following recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection?Twenty-five percent with recent SARS-Cov-2 infections and proven healing were oligo-crypto-azoospermic, despite absence virus RNA in semen.The presence SARS-CoV-2 human its role contagion after disease 2019 (COVID-19) still unclear. So far, studies evaluating occurrence infected or recovered are scarce included a limited number participants.A...
Although accumulating data have investigated the effect of SARS-CoV-2 mutations on antibody neutralizing activity, less is known about T cell immunity. In this work, we found that ancestral (Wuhan strain) Spike protein can efficaciously reactivate CD4+ memory in subjects with previous Alpha variant infection. This finding has practical implications, as many countries only one vaccine dose currently administered to individuals COVID-19, independently which was responsible We also a minority...
This study reports on the characterization of two ceftazidime-avibactam (CZA)-resistant KPC-producing Klebsiella pneumoniae strains (KP-14159 and KP-8788) sequentially isolated from infections occurred in a patient never treated with CZA. Whole-genome sequencing using combined short- long-read approach showed that both isolates belonged to same ST258 strain, had altered outer membrane porins (a truncated OmpK35 an Asp137Thr138 duplication L3 loop OmpK36), carried novel pKpQIL plasmid...
A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of cases observed January revealed that 21/52 were FDC-resistant. The was mostly sustained clonal expansion mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread...
The worldwide emergence of antibiotic resistance calls for effective exploitation existing antibiotics. Antibiotic combinations with different modes action can synergize successful treatment. In the present study, we used microcalorimetry screening to identify synergistic combination treatments against clinical MDR isolates. effects were validated in a murine infection model.The synergy meropenem combined colistin, rifampicin or amikacin was tested on 12 isolates (1 Escherichia coli, 5...
To evaluate the performance of an isothermal microcalorimetry (IMC) method for determining MICs among extensively drug-resistant Gram-negative bacilli.A collection 320 clinical isolates (n = 80 each) Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii from Sweden, Spain, Italy Netherlands were tested. The determined using IMC device calScreener (Symcel, Stockholm, Sweden) ISO-broth microdilution as reference method. Essential agreement, categorical...
Among Enterobacterales, Klebsiella pneumoniae (Kp) is one of the major opportunistic pathogens causing hospital-acquired infections. The most problematic phenomenon linked to Kp related dissemination multi-drug resistant (MDR) clones producing carbapenem-hydrolyzing enzymes, representing a clinical and public health threat at global scale. Over past decades, high-risk MDR (e.g., ST512, ST307, ST101 blaKPC-type carbepenemases) have become endemic in several countries, including Italy....
aligning with prior publications. 8,9Conversely, Manesh et al. 10 found that crushed posaconazole DR tablets given per feeding tube at a dose of 300 mg daily produced therapeutic levels after 2 weeks therapy in 19 patients receiving treatment for rhino-orbito-cerebral mucormycosis. 10any factors can impact drug tablets, spanning from the obvious patient (i.e.absorption) to terminal placement (e.g.J-tube versus G-tube) or more nuanced (preparation and administration technique).The literature...
Abstract Purpose SARS-CoV-2 infection in immunocompromised hosts is challenging, and prolonged viral shedding can be a common complication these patients. We describe the clinical, immunological, virological course of patient with eosinophilic granulomatosis polyangiitis, who developed status long-term asymptomatic carrier for more than 7 months. Methods Over study period, underwent 20 RT-PCR tests detection on nasopharyngeal swabs. In addition, cultures genetic investigation were performed....
In this work, we used a whole-genome sequencing (WGS) approach to study the features of KPC-producing Klebsiella pneumoniae (KPC-Kp) spreading in large Italian long-term acute-care rehabilitation facility (LTACRF), and track dynamics dissemination within setting. Thirty-eight, non-replicated, KPC-Kp isolates from colonized patients (either already at admission or during admission), collected 2016, were subjected antimicrobial-susceptibility testing WGS. All resistant β-lactams, with...
There is evidence that, after severe acute respiratory syndrome coronavirus 2 infection, male reproductive function and semen quality may be damaged OBJECTIVES: To evaluate a panel of inflammatory mediators in patients recovered from disease 2019.Sexually active men with previous infection proven recovery 2019 were enrolled prospective cohort study. Clinical, uro-andrological data specimens prospectively collected. For previously hospitalized patients, on serum markers retrospectively...
Human immunodeficiency virus type 1 (HIV-1) infection is characterized by persistent systemic inflammation and immune activation, even in patients receiving effective antiretroviral therapy (ART). Converging data from many cross-sectional studies suggest that gut microbiota (GM) changes can occur throughout including human (HIV) infection, treated ART; however, the results are contrasting. For first time, we compared fecal microbial composition, serum metabolites, cytokine profile of...
A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, prolonged viral shedding. Our case report supports the hypothesis that an effective response may be dispensable for control of progression to forms, while it necessary SARS-CoV-2 clearance. We a 26-year-old woman, clinical history epilepsy since age eight, who was diagnosed coronavirus disease 2019 (COVID-19) by reverse-transcriptase–polymerase-chain-reaction (RT-PCR) on nasopharyngeal swab...
FIM-1 is an acquired metallo-β-lactamase identified in a multidrug-resistant
We performed a multicentre study (2020-2022) to compare the
Alzheimer’s disease (AD) is a neurodegenerative process responsible for almost 70% of all cases dementia. The clinical signs consist in progressive and irreversible loss memory, cognitive, behavioral functions. main histopathological hallmark the accumulation amyloid-ß (Aß) peptide fibrils brain. To date, origin Aß has not been determined. Recent studies have shown that gut microbiota produces Aß, dysbiotic states identified AD patients animal models AD. Starting from hypothesis maintaining...