A5091194719- Occupational and environmental lung diseases
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Environmental Justice and Health Disparities
- Radiation Dose and Imaging
- Pleural and Pulmonary Diseases
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Healthcare Facilities Design and Sustainability
- Health disparities and outcomes
- Radioactivity and Radon Measurements
- Risk Perception and Management
- Environmental and Social Impact Assessments
- Occupational exposure and asthma
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Global Health Care Issues
- Knowledge Management and Technology
- Medical Imaging and Pathology Studies
- Cancer Risks and Factors
- Retinal and Optic Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Effects and risks of endocrine disrupting chemicals
- International Development and Aid
Istituto Superiore di Sanità
2014-2024
World Health Organization - Italy
2021-2024
World Health Organization - Pakistan
2024
National Institute of Health
2016-2020
National Centre for Disease Prevention and Control
2013
National Research Council
2012
World Health Organization Regional Office for Europe
2012
Sapienza University of Rome
2009-2012
Abstract Background Aim of the present study is to describe characteristics COVID-19-related deaths and compare clinical phenotype course occurring in adults (<65 years) older (≥65 years). Method Medical charts 3,032 patients dying with COVID-19 Italy (368 aged < 65 years 2,664 ≥65 were revised extract information on demographics, preexisting comorbidities, in-hospital complications leading death. Results Older presented a higher number comorbidities compared those <65...
This volume provides an update of the health status populations living in National Priority Contaminated Sites (NPCSs) included SENTIERI Project. is part epidemiological surveillance programme carried out NPCSs, promoted by Italian Ministry Health as a further step project started 2006, when residents contaminated sites was first addressed within Strategic Program "Environment and Health". The Report focuses on five outcomes: mortality, cancer incidence, hospital discharges, congenital...
An epidemic of asbestos-related diseases is ongoing worldwide. Mortality from malignant pleural neoplasms in Italy was analyzed, to estimate the health impact asbestos at national and local level.Mortality ICD-9 code 163 considered, time-window 1995-2002, using National Bureau Statistics data. regional standardized rates municipal Standardized Ratios (SMR) were calculated. Municipal clusters identified by applying Spatial Scan procedure. Relative risks (RR) express ratio risk within cluster...
SENTIERI project (Epidemiological Study of Residents in Italian Contaminated Sites) studied mortality the sites national interest for environmental remediation (National Priority Sites—NPCSs). described residents NPCSSs, and it specifically focused on causes death which exposure is suspected or ascertained to play an etiologic role. The epidemiological evidence causal association was classified a priori into one these three categories: Sufficient (S), Limited (L), Inadequate (I). Mortality...
Spatial distribution of mortality from pleural mesothelioma (which in the ICD-10 Revision has a specific code: C45.0) Italy for period 2003-2009 is described. Previous studies at national level employed topographic code "Malignant neoplasms pleura", because unavailability ICD-9 mesothelioma.Standardized ratios were computed all municipalities, using each regional population as reference; municipalities Regions with rate higher than rate, latter been used reference. SMRs specifically also...
Amphibolic fibres with fluoro-edenitic composition characterize Biancavilla soil, including the major quarry from which building materials have been extensively extracted. These induce mesothelioma in experimental animals and their vitro biological action is similar to that of crocidolite. Malignant case series incidence were examined evaluate disease burden on inhabitants. The pleural steadily higher than Sicilian Region, risk estimates are more elevated women men, most affected age class...
Abstract Background Among the unknowns posed by coronavirus disease 2019 (COVID-19) outbreak, role of biological sex to explain susceptibility and progression is still a matter debate, with limited sex-disaggregated data available. Methods A retrospective analysis was performed assess if differences exist in clinical manifestations transitions care among hospitalized individuals dying laboratory-confirmed SARS-CoV-2 infection Italy (February 27–June 11, 2020). Clinical characteristics times...
The aim of the present study was to investigate incidence breast (females), prostate, testicular, and thyroid cancer in Italian National Priority Contaminated Sites (NPCSs), served by registries, where presence endocrine disruptors (EDs), reported be linked these tumours, documented. Evidence carcinogenicity EDs NPCSs assessed based on evaluation international scientific institutions committees. Standardized Incidence Ratios (SIRs) were computed for each NPCS site between 1996 2005. Excess...
Asbestos is one of the major worldwide occupational carcinogens. The global burden asbestos-related diseases (ARDs) was estimated around 231,000 cases/year. Italy main European asbestos producers until 1992 ban. WHO recommended national programs, including epidemiological surveillance, to eliminate ARDs. present paper shows estimate mortality from ARDs in Italy, established for first time. National standardized rates mesothelioma and asbestosis their temporal trends, based on Institute...
Background and history: Italy was the main asbestos producer one of greatest consumers in 20th century Europe until ban introduced 1992. Asbestos exposure affected population a wide range working environments, namely mining marketing asbestos, cement production, shipyards textile industries. This also determined widespread environmental affecting surrounding communities. Methods: To investigate drivers difficulties process leading to its subsequent implementation, we focused on stakeholder...
The incidence of cancer among residents in sites contaminated by pollutants with a possible health impact is not adequately studied. In Italy, SENTIERI Project (Epidemiological study National Priority Contaminated Sites, NPCSs) was implemented to major outcomes for 44 NPCSs.The Italian Association Cancer Registries (AIRTUM) records 23 NPCSs. For each NPCSs, the all malignant cancers combined and 35 (coded according ICD-10), analysed (1996-2005). observed cases were compared expected based on...
The territory around the industrial Sicilian area of Priolo, Italy, has been defined as a contaminated site (CS) national priority for remediation because diffuse environmental contamination caused by large settlements. present study investigates spatial distribution cancer into CS (period 1999-2006). Different geographical methods used evaluation impact air pollutants were adopted. Using database Syracuse Province Cancer Registry, gender-specific standardised incidence ratios calculated 35...
The association between cancer incidence and the residence near polluting facilities in an industrial area nearby Taranto has been investigated. Age, sex occupational exposure were controlled as confounding variables a case-control study (658 cases, 2092 controls). High risks evidenced close to steel mill (OR: 3.54), coke plant 4.80), mineral deposit 3.33) shipbuilding 4.29) for pleural neoplasm, 1.65) 1.79) lung cancer. After adjustment exposure, increasing trends of risk observed both...
As part of a surveillance plan active since the early 1990s, this study evaluates malignant mesothelioma (MM) mortality for time-window 2010–2019 in Italy, country that banned asbestos 1992. National and regional rates MM, municipal standardized ratios (all mesotheliomas, pleural (MPM) peritoneal (MPeM)), by gender age group were calculated. A clustering analysis was also performed. There 15,446 deaths from MM (11,161 males, 3.8 × 100,000; 4285 females, 1.1 100,000), which 12,496 MPM 661...
Abstract Background Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 not been investigated. Methods A random sample 6085 individuals Italy who died in-hospital confirmed between February and December 2020 were included. Observed expected (O/E) ratios disease pairs computed logistic regression models used determine the association O/E values ≥ 1.5. Results Six diseases exhibited 1.5 statistically significant...
Data from a pilot study on unmetabolized benzene and trans,trans muconic acid (t,t-MA) excretion in filling station attendants unexposed controls were used to afford methodological issues the biomonitoring of low exposures (around 0.1 ppm). Urinary concentrations t,t-MA measured by dynamic head-space capillary GC/FID HPLC, respectively. The accuracy HPLC determination was assessed terms inter- intra-method reliability. adequacy urinary as biological markers exposure evaluated analysing...
The area of Gela was included among the 57 Italian polluted sites national interest for environmental remediation because its widespread contamination from a petrochemical complex. present study investigates mortality and morbidity cohort workers with aim disentangling occupational residential risk. Mortality assessed 5,627 men hired 1960, year plant start-up, to 1993; it followed up vital status in period 1960–2002. Morbidity analysed 5,431 neither dead nor lost follow-up 1960 2001 based on...