A5024163149- Immune Cell Function and Interaction
- HIV Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- interferon and immune responses
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- Infant Nutrition and Health
- HIV-related health complications and treatments
- Autoimmune and Inflammatory Disorders Research
- DNA Repair Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Center for Global Health
2024
Bambino Gesù Children's Hospital
2024
Istituto Superiore di Sanità
2013-2024
Macrophages are key targets of HIV-1 infection. We have previously described that the expression CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by exposure. Moreover, CCL2 acts as an autocrine factor promotes viral replication in infected macrophages. In this study, we dissected molecular mechanisms which neutralization inhibits monocyte-derived (MDM), potential involvement innate restriction factors protein sterile alpha...
The CCL2/CC chemokine receptor 2 axis plays key roles in the pathogenesis of HIV-1 infection. We previously reported that exposure monocyte-derived macrophages to CCL2 neutralizing antibody (αCCL2 Ab) restricted replication at postentry steps viral life cycle. This effect was associated with induction transcripts coding for innate antiviral proteins, including APOBEC3A and RSAD2. study aimed identifying signaling pathways involved these factors by blocking macrophages. Through a combination...
Macrophages are key targets of HIV-1 infection and main producers the pro-inflammatory chemokine CCL2, whose expression is induced by both in vitro vivo. We previously found that CCL2 neutralization monocyte derived-macrophages (MDMs) strongly inhibited replication affecting post-entry steps viral life cycle. Here, we used RNA-sequencing to deeply characterize cellular factors pathways modulated blocking MDMs involved restriction. report exposure neutralizing antibody profoundly affected MDM...
Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation cytokine and chemokine secretion. In this study, we demonstrate that bovine LF (bLF) up-modulates, in concentration- time-dependent manner, CCL1 secretion monocytes (Mo) at the early stage differentiation toward dendritic cells (DCs), fully differentiated immature Mo-derived DCs (MoDCs). both cell types, up-modulation is an event following bLF-mediated enhanced accumulation transcripts. Notably,...
The Epstein-Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of host immune system. However, EBV associated with various malignant diseases that preferentially develop immunodeficient individuals. Accumulating evidence suggests important role for NK cells, though mechanisms by which evades or triggers cell responses are poorly understood. Here, we generated EBV-immortalized lymphoblastoid lines...
<p>Table S1. Characteristics of all enrolled patients (HCC=35, CRC=16), not previous treated with chemotherapy Table S2. List antibodies for FC analysis Figure S1: CD4 and CD8 T cells expressed high levels PD1 in TUM district showed mostly an effector memory phenotype CRC S2: Distribution Wnt3a serum, NTUM- or TUM-derived CM, expression Wnt3a/β-catenin axis NTUM TUM-infiltrating from S3: Analysis Frizzled receptor 1 among periphery, nontumor tumor samples HCC S4: β-catenin+...
<div>Abstract<p>In this study, we investigated the role of Wnt/β-catenin signaling pathway in antitumor immune responses. We report that concentration secreted Wnt3a was significantly higher conditioned medium from tumor or nontumor tissues obtained all hepatocellular carcinoma colorectal cancer patients tested, than serum healthy donors patients. In addition, both and β-catenin were overexpressed by tumor-infiltrating nontumor-infiltrating CD4<sup>+</sup>...
Background Monocyte/macrophages are reservoirs capable of producing replication-competent HIV virions for many years despite suppressive HAART. APOBEC3 proteins represent critical determinants monocyte resistance to HIV-1 infection, and their decreased expression during macrophage differentiation results in a permissive target cell population. Chemokines receptors deeply involved infection control. Monocytes/ macrophages the major source CCL2 vitro vivo. Growing evidences suggest that plays...
<p>Table S1. Characteristics of all enrolled patients (HCC=35, CRC=16), not previous treated with chemotherapy Table S2. List antibodies for FC analysis Figure S1: CD4 and CD8 T cells expressed high levels PD1 in TUM district showed mostly an effector memory phenotype CRC S2: Distribution Wnt3a serum, NTUM- or TUM-derived CM, expression Wnt3a/β-catenin axis NTUM TUM-infiltrating from S3: Analysis Frizzled receptor 1 among periphery, nontumor tumor samples HCC S4: β-catenin+...