A5079947669- Multiple Sclerosis Research Studies
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Caveolin-1 and cellular processes
- Hepatitis C virus research
- Cell death mechanisms and regulation
- Medical and Biological Ozone Research
- Corneal surgery and disorders
- IL-33, ST2, and ILC Pathways
- Inflammation biomarkers and pathways
- Neurogenesis and neuroplasticity mechanisms
- Infant Nutrition and Health
- Corneal Surgery and Treatments
- Plant Molecular Biology Research
- Cytokine Signaling Pathways and Interactions
- Immune responses and vaccinations
- Adipose Tissue and Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Fatty Acid Research and Health
Fondazione Santa Lucia
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Istituto Superiore di Sanità
2014-2017
University of Maryland, Baltimore
2010
Abstract Background Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, and demyelinating disease of the central nervous system (CNS). Several cytokines are thought to be involved in regulation MS pathogenesis. We recently identified interleukin (IL)-9 as a cytokine reducing inflammation protecting from neurodegeneration relapsing–remitting patients. However, expression IL-9 CNS, mechanisms underlying effect on CNS infiltrating immune cells have never been investigated....
Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local systemic level, the inflammatory status immune response. Obesity-associated inflammation dysfunctions are inextricably linked tumor but, in spite of intense efforts, mechanisms underpinning this association remain elusive. In report, we characterized profile VAT-associated circulating innate lymphocyte regulatory T (Treg) cell subsets underlying conditions, such as obesity...
ABSTRACT Dendritic cells (DCs) are fundamental for the initiation of immune responses and important players in AIDS immunopathogenesis. The modulation DC functional activities represents a strategic mechanism HIV-1 to evade surveillance. Impairment function may result from bystander effects envelope proteins independently direct infection. In this study, we report that exposure immature monocyte-derived DCs (MDDCs) R5 gp120 resulted CCR5-dependent production interleukin-6 (IL-6) via...
Obesity is a low-grade chronic inflammatory state representing an important risk factor for colorectal cancer (CRC). Adipocytes strongly contribute to inflammation by producing mediators. In this study we investigated the role of human visceral fat adipocytes in regulating functions innate immunity cells. Adipocyte-conditioned media (ACM) from obese (n = 14) and CRC (lean, n 14; obese, 13) subjects released higher levels pro-inflammatory/immunoregulatory factors as compared ACM healthy lean...
Abstract Highly active antiretroviral therapy has significantly improved the prognosis of HIV-infected subjects. However, patients treated long term still manifest increased mortality and, even with undetectable plasma viremia, often experience persistent immune activation. Furthermore, liver-related is now most common cause non-AIDS-related death in individuals on highly through accelerated fibrosis progression. TLRs are first line host response to pathogens and play an important role human...
Primary-progressive (PP) and secondary-progressive (SP) multiple sclerosis (MS) are characterized by neurological deficits caused a permanent neuronal damage, clinically quantified the expanded disability status scale (EDSS). Neuronal tissue damage is also mediated immune infiltrates producing soluble factors, such as cytokines chemokines, which released in cerebrospinal fluid (CSF). The mechanisms regulating production of factor not completely defined. Using multiplex bead-based assays, we...
Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin-9 (IL-9) emerging as pleiotropic cytokine involved in MS pathophysiology.
MicroRNAs (miRs) are an abundant class of small non-coding RNAs (~22 nt) that reprogram gene expression by targeting mRNA degradation and translational disruption. An emerging concept implicates miR coupling with transcription factors in myeloid cell development function, thus contributing to host defense inflammation. The important role these molecules play the pathogenesis HIV-1 is only now emerging. We provide evidence exposure monocyte-derived dendritic cells (MDDCs) recombinant R5...
Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation cytokine and chemokine secretion. In this study, we demonstrate that bovine LF (bLF) up-modulates, in concentration- time-dependent manner, CCL1 secretion monocytes (Mo) at the early stage differentiation toward dendritic cells (DCs), fully differentiated immature Mo-derived DCs (MoDCs). both cell types, up-modulation is an event following bLF-mediated enhanced accumulation transcripts. Notably,...
Event Abstract Back to Immunomodulatory effects of HIV-1 gp120 on human dendritic cells: role STAT3/IL-6 axis Manuela Del Cornò1, Gloria Donninelli1, Barbara Varano1, Andrea Masotti2, Letizia Da Sacco2 and Sandra Gessani1* 1 Istituto Superiore di Sanità, Italy 2 Bambino Gesù Children's Hospital, The ability exploit the host immune responses its own advantage is critical in pathogenesis AIDS. Since cells (DCs) are key players induction responses, modulation their functional activities...