A5064424544- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Peripheral Neuropathies and Disorders
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
- Herpesvirus Infections and Treatments
- Nerve injury and regeneration
- Cannabis and Cannabinoid Research
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Rheumatoid Arthritis Research and Therapies
- Circular RNAs in diseases
- Sphingolipid Metabolism and Signaling
- Toxin Mechanisms and Immunotoxins
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunotherapy and Immune Responses
- Inflammation biomarkers and pathways
- Cerebrovascular and Carotid Artery Diseases
Istituto Neurologico Mediterraneo
2021-2024
University of Rome Tor Vergata
2017-2024
Fondazione Santa Lucia
2017
Background: Astrocytes and microglia play an important role in the inflammatory process of multiple sclerosis (MS). We investigated associations between cerebrospinal fluid (CSF) levels glial fibrillary acid protein (GFAP) soluble triggering receptors expressed on myeloid cells-2 (sTREM-2), molecules, clinical characteristics a group patients with relapsing-remitting MS (RRMS). Methods: Fifty-one RRMS participated study. Clinical evaluation CSF collection were performed at time diagnosis....
Experimental studies identified a role of neuroinflammation in the pathogenesis neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). However, inflammatory molecules as diagnostic and prognostic biomarkers patients with ALS is unclear. In this cross-sectional study, cerebrospinal fluid (CSF) levels set cytokines chemokines were analyzed 56 newly diagnosed 47 age- sex-matched control without or degenerative neurological disorders. The included: interleukin (IL)-1β, IL-2,...
The endocannabinoid system (ECS) has been recently recognized as a prominent promoter of the emotional homeostasis, mediating effects different environmental signals including rewarding and stressing stimuli. ECS modulates stimuli, influencing synaptic transmission in dopaminergic projections to limbic system, mediates neurophysiological behavioral consequences stress. Notably, individual psychosocial context is another key element modulating activity ECS. Finally, inflammation represents an...
The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention the field multiple sclerosis (MS) research but it still its infancy. In present study, we observed a large sample MS patients that let-7b-5p levels cerebrospinal fluid (CSF) were highly correlated with number implicated MS, as well variety inflammation-related protein factors, showing specific expression patterns coherent let-7b-5p-mediated regulation. Additionally, found CSF...
Exercise is increasingly recommended as a supportive therapy for people with Multiple Sclerosis (pwMS). While clinical research has still not disclosed the real benefits of exercise on MS disease, animal studies suggest substantial beneficial effect motor disability and pathological hallmarks such central peripheral dysregulated immune response. The hippocampus, core area memory formation learning, brain region involved in pathophysiology. Human rodent that hippocampus highly sensitive to...
Background: Synaptic plasticity helps in reducing the clinical expression of brain damage and represents a useful mechanism to compensate negative impact new lesions multiple sclerosis (MS). Inflammation, altering synaptic plasticity, could negatively influence disease course relapsing-remitting MS (RR-MS). Objective: In present study, we explored whether interleukin (IL)-6, major proinflammatory cytokine involved pathogenesis, alters affects ability for ongoing damage. Methods: The effect...
Future treatments of multiple sclerosis (MS), a chronic autoimmune neurodegenerative disease the central nervous system (CNS), aim for simultaneous early targeting peripheral immune function and neuroinflammation. Sphingosine-1-phosphate (S1P) receptor modulators are among most promising drugs with both "immunological" "non-immunological" actions. Selective S1P have been recently approved MS shown clinical efficacy in its mouse model, experimental encephalomyelitis (EAE). Here, we...
Abstract Aim We recently proposed miR‐142‐3p as a molecular player in inflammatory synaptopathy, new pathogenic hallmark of multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE), that leads to neuronal loss independently demyelination. MiR‐142‐3p seems be unique among potential biomarker candidates MS, since it is an miRNA playing dual role the immune central nervous systems. Here, we aimed verify impact circulating cerebrospinal fluid (CSF) MS patients...
Elevated levels of specific proinflammatory molecules in the cerebrospinal fluid (CSF) have been associated with disability progression, enhanced neurodegeneration and higher incidence mood disorders people multiple sclerosis (MS). Studies animal models MS suggest that preventive exercise may play an immunomodulatory activity, beneficial effects on both motor deficits behavioral alterations. Here we explored impact lifestyle physical activity clinical presentation central inflammation a...
Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation neurodegeneration multiple sclerosis (MS), promoting a worse disease course. Osteopontin is also likely acute MS relapses.In 47 patients relapsing-remitting MS, we explored the correlation between time elapsed last clinical relapse lumbar puncture, cerebrospinal fluid (CSF) levels of osteopontin group inflammatory cytokines...
In multiple sclerosis (MS), fatigue is a frequent symptom that negatively affects quality of life. The pathogenesis multifactorial and inflammation may play specific role. To explore the association between fatigue, central disease course in MS 106 relapsing-remitting (RR)-MS patients, clinical characteristics, including mood, were explored at time diagnosis. NEDA (no evidence activity)-3 status after one-year follow up was calculated. Cerebrospinal fluid (CSF) levels set proinflammatory...
In multiple sclerosis, only immunomodulatory and immunosuppressive drugs are recognized as disease-modifying therapies. However, in recent years, several data from pre-clinical clinical studies suggested a possible role of physical exercise therapy sclerosis. Current evidence is sparse often conflicting, the mechanisms underlying neuroprotective antinflammatory sclerosis have not been fully elucidated. Data, mainly derived studies, suggest that could enhance long-term potentiation thus...
In patients with multiple sclerosis (MS), a typical pattern of muscle tone alteration, known as spasticity, is frequently observed in combination other signs or symptoms such spasms, cramps, pain, bladder dysfunction, sleep disturbances, fatigue, and tremor. Recently, the concept spasticity-plus syndrome (SPS) has been proposed to take into account frequent coexistence all these complaints MS common pathophysiological basis for this putative new clinical entity proposed. Muscle tone, sleep,...
The clinical course of multiple sclerosis (MS) is critically influenced by the interplay between inflammatory and neurodegenerative processes. brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265), one most studied single-nucleotide polymorphisms (SNPs), influences brain functioning processes in healthy individuals several neuropsychiatric diseases. However, role this MS still controversial. In 218 relapsing–remitting (RR)-MS patients, we explored, at time diagnosis,...
TNF-dependent synaptotoxicity contributes to the neuronal damage occurring in patients with Multiple Sclerosis (pwMS) and its mouse model Experimental Autoimmune Encephalomyelitis (EAE). Here, we investigated miR-142-3p, a synaptotoxic microRNA induced by inflammation EAE MS, as potential downstream effector of TNF signalling.
Introduction The visual system is a prominent site of damage in MS since the earliest phases disease. Altered low-contrast acuity (LCVA) test has been associated with impairment and retinal degeneration, predicting medium- long-term disability. However, it unclear whether LCVA may also represent reliable measure neuroinflammation predictor disease evolution very early stages MS. Methods We explored group 76 consecutive newly diagnosed relapsing–remitting (RR-MS) patients without or altered...
Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin-9 (IL-9) emerging as pleiotropic cytokine involved in MS pathophysiology.
Neurodegenerative and inflammatory processes influence the clinical course of multiple sclerosis (MS). The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has been associated with cognitive dysfunction, deposition neuroinflammation in Alzheimer's disease. We explored a group 50 patients relapsing-remitting MS association between cerebrospinal fluid (CSF) levels BACE1, characteristics at time diagnosis prospective disability after three-years follow-up. In addition, we assessed...
Abstract The neuroinflammatory process characterizing multiple sclerosis (MS) is associated with changes in excitatory synaptic transmission and altered central concentrations of the primary amino acid, L‐glutamate (L‐Glu). Recent findings report that cerebrospinal fluid (CSF) levels L‐Glu positively correlate pro‐inflammatory cytokines MS patients. However, to date, there no evidence about relationship between other L‐aspartate (L‐Asp), its derivative D‐enantiomer, D‐aspartate,...