A5012234975- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- RNA regulation and disease
- MicroRNA in disease regulation
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Nerve injury and regeneration
- Dermatology and Skin Diseases
- Nicotinic Acetylcholine Receptors Study
- Ion Channels and Receptors
- Cytokine Signaling Pathways and Interactions
- Calcium signaling and nucleotide metabolism
- Toxoplasma gondii Research Studies
- Extracellular vesicles in disease
- Inflammation biomarkers and pathways
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2018-2024
University of Rome Tor Vergata
2012-2024
IRCCS Ospedale San Raffaele
2018-2023
Istituto Neurologico Mediterraneo
2017-2018
Fondazione Santa Lucia
2011-2017
Data from multiple sclerosis (MS) and the MS rodent model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy at basis of neurodegenerative damage causing irreversible disability in these disorders. This is characterized by imbalance between glutamatergic GABAergic transmission has been proposed to be a potential therapeutic target. Siponimod (BAF312), selective sphingosine 1-phosphate1,5 receptor modulator, currently under investigation...
Cerebellar deficit contributes significantly to disability in multiple sclerosis (MS). Several clinical and experimental studies have investigated the pathophysiology of cerebellar dysfunction this neuroinflammatory disorder, but cellular molecular mechanisms are still unclear. In autoimmune encephalomyelitis (EAE), a mouse model MS, proinflammatory cytokines, together with degeneration inhibitory neurons, contribute impair GABAergic transmission at Purkinje cells (PCs). Here, we...
MicroRNAs (miRNA) play an important role in post-transcriptional gene regulation of several physiological and pathological processes. In multiple sclerosis (MS), a chronic inflammatory degenerative disease the CNS, its mouse model, experimental autoimmune encephalomyelitis (EAE), miRNA dysregulation has been mainly related to immune system dysfunction white matter (WM) pathology. However, little is known about their gray Here, we explored involvement inflammation-driven alterations synaptic...
Abstract The N-palmitoylethanolamine (PEA) is an endogenous member of the endocannabinoid system (ECS) with several biological functions, including a neuromodulatory activity in central nervous system. To shed light on neuronal function PEA, we investigated its involvement control both excitatory and inhibitory transmission murine striatum, brain region strongly modulated by ECS. By means electrophysiological recordings, showed that PEA modulates synaptic transmission, through activation...
The endocannabinoid system (ECS) is critically involved in the pathophysiology of Multiple Sclerosis (MS), a neuroinflammatory and neurodegenerative disease central nervous (CNS). Over past decade, researchers have extensively studied neuroprotective anti-inflammatory effects ECS. Inhibiting degradation 2-arachidonoylglycerol (2-AG) has emerged as promising strategy to mitigate brain damage MS. In this study, we investigated novel reversible MAGL inhibitor (MAGLi 432) on C57/BL6 female mice...
Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the disabling symptoms associated with disease. Anatomical, biochemical, pharmacological evidence indicates that type-1 cannabinoid receptor (CB1R) is implicated control emotional behavior modulated during inflammatory neurodegenerative diseases such as MS experimental autoimmune encephalomyelitis (EAE).We investigated whether CB1R could exert a role...
The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention the field multiple sclerosis (MS) research but it still its infancy. In present study, we observed a large sample MS patients that let-7b-5p levels cerebrospinal fluid (CSF) were highly correlated with number implicated MS, as well variety inflammation-related protein factors, showing specific expression patterns coherent let-7b-5p-mediated regulation. Additionally, found CSF...
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. MS characterized by infiltrations leukocytes such as T and B lymphocytes macrophages. Macrophages have been identified major effectors inflammation demyelination in both its animal model, experimental autoimmune encephalomyelitis (EAE). However, activation heterogeneity macrophages has poorly investigated. Thus, this study, we evaluated M1 M2 immunophenotype from EAE control mice analyzing over...
Exercise is increasingly recommended as a supportive therapy for people with Multiple Sclerosis (pwMS). While clinical research has still not disclosed the real benefits of exercise on MS disease, animal studies suggest substantial beneficial effect motor disability and pathological hallmarks such central peripheral dysregulated immune response. The hippocampus, core area memory formation learning, brain region involved in pathophysiology. Human rodent that hippocampus highly sensitive to...
Glutamate transmission is dysregulated in both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the animal model of MS. A characteristic EAE increased glutamate associated with up-regulation AMPA receptors. However, little known about role NMDA receptors synaptic modifications induced by EAE.The contribution to alterations disease severity mice was assessed means neurophysiological, morphological, Western blot, metabolic clinical score assessments.In our mice,...
Future treatments of multiple sclerosis (MS), a chronic autoimmune neurodegenerative disease the central nervous system (CNS), aim for simultaneous early targeting peripheral immune function and neuroinflammation. Sphingosine-1-phosphate (S1P) receptor modulators are among most promising drugs with both "immunological" "non-immunological" actions. Selective S1P have been recently approved MS shown clinical efficacy in its mouse model, experimental encephalomyelitis (EAE). Here, we...
Abstract Aim We recently proposed miR‐142‐3p as a molecular player in inflammatory synaptopathy, new pathogenic hallmark of multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE), that leads to neuronal loss independently demyelination. MiR‐142‐3p seems be unique among potential biomarker candidates MS, since it is an miRNA playing dual role the immune central nervous systems. Here, we aimed verify impact circulating cerebrospinal fluid (CSF) MS patients...