A5091036553- Multiple Sclerosis Research Studies
- Nerve injury and regeneration
- Neurogenetic and Muscular Disorders Research
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Polyomavirus and related diseases
- Neurogenesis and neuroplasticity mechanisms
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Amyotrophic Lateral Sclerosis Research
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- DNA Repair Mechanisms
- Dermatology and Skin Diseases
- Cell death mechanisms and regulation
- Pain Mechanisms and Treatments
- Clostridium difficile and Clostridium perfringens research
- Adenosine and Purinergic Signaling
- Parkinson's Disease Mechanisms and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phytochemistry and Biological Activities
- Viral-associated cancers and disorders
Fondazione Santa Lucia
2013-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2022
National Institute of Neurological Disorders and Stroke
2018
It has long been known that multiple sclerosis (MS) is associated with an increased Epstein-Barr virus (EBV) seroprevalence and high immune reactivity to EBV infectious mononucleosis increases MS risk. This evidence led postulate infection plays a role in etiopathogenesis, although the mechanisms are debated. study was designed assess prevalence magnitude of CD8+ T-cell responses latent (EBNA-3A, LMP-2A) lytic (BZLF-1, BMLF-1) antigens relapsing-remitting patients (n = 113) healthy donors...
Data from multiple sclerosis (MS) and the MS rodent model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy at basis of neurodegenerative damage causing irreversible disability in these disorders. This is characterized by imbalance between glutamatergic GABAergic transmission has been proposed to be a potential therapeutic target. Siponimod (BAF312), selective sphingosine 1-phosphate1,5 receptor modulator, currently under investigation...
Background: Alterations of intestinal permeability (IP) may contribute to the pathophysiology immune-mediated diseases. Objective: We investigated possible association between IP changes and multiple sclerosis (MS). Methods: studied 22 patients with relapsing–remitting (RRMS) 18 age- sex-matched healthy donors (HDs), including five twin pairs (one concordant, four discordant for disease). Measurement lactulose (L) mannitol (M; two non-metabolized sugars) levels in urine samples, after an...
Multiple sclerosis (MS) is characterized by macrophage accumulation and inflammatory infiltrates into the CNS contributing to demyelination. Because purinergic P2X7 receptor (P2X7R) known be abundantly expressed on cells of hematopoietic lineage nervous system, we further investigated its phenotypic expression in MS experimental autoimmune encephalomyelitis conditions. By quantitative reverse transcription polymerase chain reaction flow cytometry, analyzed P2X7R human mononuclear peripheral...
// Nélida I. Noguera 1, 2 , Elvira Pelosi 3 Daniela F. Angelini 4 Maria Liliana Piredda Gisella Guerrera Eleonora Piras Luca Battistini Lauretta Massai 5 Anna Berardi 6 Gianfranco Catalano Laura Cicconi 1 Germana Castelli Agnese D'Angiò Pasquini Grazia Graziani 7 Giuseppe Fioritoni Teresa Voso Domenico Mastrangelo Ugo Testa Francesco Lo-Coco Department of Biomedicine and Prevention, University Rome Tor Vergata, Rome, Italy Santa Lucia Foundation, I.R.C.C.S. Via del Fosso di Fiorano,...
The composition of the intestinal microbiota plays a critical role in shaping immune system. Modern lifestyle, inappropriate use antibiotics, and exposure to pollution have significantly affected commensal microorganisms. has been shown sustain autoimmune responses at distant sites animal models disease, may also immune-mediated central nervous system (CNS) diseases such as multiple sclerosis (MS). We studied gut mycobiota fecal samples from 27 persons with MS (pwMS) 18 healthy donors (HD),...
Background and objective: One third of children with epilepsy are refractory to medications. Growing data support a role common childhood infections neurotropic viruses inflammation in epileptogenesis. Our objective was determine the frequency Human Herpesvirus-6 (HHV-6) Epstein-Barr Virus (EBV) infection cytokine levels saliva from seizures compared healthy controls febrile illness without seizures. Methods: In this cross-sectional multi-center study, we collected 115 consecutive acute...
Adult neurogenesis is a multistep process regulated by several extrinsic factors, including neurotrophins. Among them, little known about the role of nerve growth factor (NGF) in neurogenic niches mouse. Here we analyzed biology adult neural stem cells (NSCs) from subventricular zone (SVZ) AD11 anti-NGF transgenic mice, which expression recombinant antibody aD11 leads to chronic postnatal neutralization endogenous NGF. We showed that AD11-NSCs proliferate 10-fold less, with respect their...
Neuropathic pain (NeP) in humans is often a life-long condition with no effective therapy available. The higher incidence of female gender NeP onset worldwide reported, and although the cause generally attributed to sex hormones, actual mechanisms players involved are still unclear. Glial immune cells take part development, orchestrate neuroimmune inflammatory response, releasing pro-inflammatory factors chemoattractant properties that activate resident recruit from circulation. neuro-immune...
Recent preclinical and clinical evidence suggest that immune system has a role in the progression prognosis of Amyotrophic Lateral Sclerosis (ALS), but identification clear mechanism players remains to be elucidated. Here, we have investigated, 30 60 days (presymptomatic) 120 (symptomatic) old SOD1-G93A mice, systemic, peripheral, central innate adaptive inflammatory response, correlating it with neurodegeneration neuromuscular junction, sciatic nerves, spinal cord. Surprisingly, found very...
<h3>Objective</h3> Infection with Epstein-Barr virus (EBV) has been associated clinical activity and risk of developing MS. The purpose this study is to investigate the impact glatiramer acetate (GA) therapy on EBV-specific immune responses disease course. <h3>Methods</h3> We characterized CD8 T lymphocytes B cells during disease-modifying treatments in 2 groups patients designed a 2-pronged approach consisting cross-sectional (39 untreated patients, 38 who had undergone 12 months GA...
Objective: to investigate whether siponimod, in addition its peripheral immune-modulation, might exert direct neuroprotective effects. Background: data from Multiple Sclerosis (MS) patients and the MS animal model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy affecting brain. In EAE, this characterized by imbalance between glutamatergic GABAergic transmission, has been shown be a potential therapeutic target. Siponimod, selective...