A5028649034- Sarcoma Diagnosis and Treatment
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Bone fractures and treatments
- Immune Cell Function and Interaction
- Parathyroid Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- interferon and immune responses
- Hematological disorders and diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Diagnosis and Treatment
- Bone and Dental Protein Studies
- Fatty Acid Research and Health
- Lymphoma Diagnosis and Treatment
- Animal Virus Infections Studies
- Pediatric health and respiratory diseases
- Management of metastatic bone disease
- Adipose Tissue and Metabolism
- Orthopaedic implants and arthroplasty
- Bone health and treatments
- Musculoskeletal synovial abnormalities and treatments
CTO Hospital
2022-2025
Sapienza University of Rome
1995-2022
University of Siena
2022
Institute of Molecular Medicine
2020
Istituto Superiore di Sanità
2016
Obesity is a low-grade chronic inflammatory state representing an important risk factor for colorectal cancer (CRC). Adipocytes strongly contribute to inflammation by producing mediators. In this study we investigated the role of human visceral fat adipocytes in regulating functions innate immunity cells. Adipocyte-conditioned media (ACM) from obese (n = 14) and CRC (lean, n 14; obese, 13) subjects released higher levels pro-inflammatory/immunoregulatory factors as compared ACM healthy lean...
The assay of serum peptides bone collagen formation and degradation could potentially provide an indirect estimate the rate turnover. In our study we have measured levels carboxy-terminal propeptide type I procollagen (PICP) as a marker pyridinoline cross-linked telopeptide domain (ICTP) resorption in 53 patients (47.7 ± 10 years, M SD) on haemodialysis (for 9.5 3.8 years) affected by renal osteodystrophy. Besides PICP ICTP, were also sampled for intact C-terminal PTH, osteocalcin (BGP)...
SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity limits availability of intracellular dNTP pools. In the present study, we demonstrate expression was increased following human cytomegalovirus (HCMV) infection, with only modest effect infectious virus production. rapidly phosphorylated at residue T592 after infection by cellular cyclin-dependent kinases, especially...
Once COPD is established, pulmonary lesions can only progress and smoking cessation by itself not sufficient to switch off persistent lung inflammation. Similarly, in former-smoker mice, neutrophil inflammation persists undergo progressive deterioration. The molecular mechanisms underlying disease progression the inefficiency of quenching neutrophilic were studied male C57 Bl/6 mice after 6 months rest from cessation. As compared with that continued smoke, showed reduced expression histone...
Intramedullary nail fixation is commonly used for prophylactic stabilization of impending and complete pathological fractures the long bones. However, metallic artifacts complicate imaging evaluation bone healing or tumor progression postoperative radiation planning. Carbon-fiber implants have gained popularity as an alternative, given their radiolucency superior axial bending. This study evaluates incidences mechanical nonmechanical complications.
Abstract Carbon-fiber (CF) plates are a promising alternative to metal plates. However, reported experience in orthopaedic oncology remains limited. The aim of this study was identify complications patients with bone tumors treated CF Between February 2015 and May 2021, 13 centers retrospectively registered that were reconstructed using Complications identified, timing etiology noted. Similar tabulated classified based on mechanical, non-mechanical paediatric complications. Mechanical...
Human cytomegalovirus (HCMV) infection often leads to systemic disease in immunodeficient patients and congenitally infected children. Despite its clinical significance, the exact mechanisms contributing HCMV pathogenesis outcomes have yet be determined. One of such involves HCMV-mediated NK cell immune response, which favors viral evasion by hindering cell-mediated cytolysis. This process appears dependent on extent genetic variation as high levels variability genes involved escape an...
Synovial sarcoma is a rare malignant mesenchymal neoplasm mostly affecting young adults, characterized by specific translocation which results in the fusion of SS18 gene on chromosome 18 with one three highly homologous SSX genes X. Its morphological diagnosis, especially monophasic or poorly differentiated variants, can be challenging because histological features often overlap other tumors. Until recently, differential diagnosis relied use cytogenetic molecular analyses to detect...
e14529 Background: PD-L1 is the only biomarker that has been accepted to identify patients who could potentially benefit from immune checkpoint inhibitors (ICIs) administration, but also negative tumors respond immunotherapy. However, other biomarkers have proposed they are too expensive and actually, there not a consensus for detection analytical methods. Thus, an urgent need inexpensive reproducible tests better optimize clinical use of ICIs. Recent findings suggest host parameters may...