A5086868436- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- Cardiovascular Syncope and Autonomic Disorders
- Family and Patient Care in Intensive Care Units
- Cardiovascular and Diving-Related Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Heavy Metal Exposure and Toxicity
- Anesthesia and Sedative Agents
- Asthma and respiratory diseases
- Nosocomial Infections in ICU
- Inflammation biomarkers and pathways
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- COVID-19 Impact on Reproduction
- Mercury impact and mitigation studies
- Cardiac Arrest and Resuscitation
Wroclaw Medical University
2015-2025
Wroclaw University of Health and Sport Sciences
2015
Early detection, standardized therapy, adequate infrastructure and strategies for quality improvement should constitute essential components of every hospital's sepsis plan. To investigate the extent to which recommendations from guidelines are implemented availability care patients with in acute hospitals. A multidisciplinary cross-sectional questionnaire was used This included use definitions, implementation guideline recommendations, diagnostic therapeutic infrastructure, antibiotic...
Gastrointestinal (GI) failure can be both a cause of sepsis and consequence the systemic pro-inflammatory response in sepsis. Changes biomarkers enterocyte damage, citrulline I-FABP (intestinal fatty acid binding protein), may indicate altered intestinal permeability damage. The study group consisted patients with (N = 28) septic shock 30); control included without infection 10). Blood samples were collected for 4-point AGI score (acute GI injury score) was calculated to monitor function on...
To evaluate the effectiveness of endotoxin elimination with an adsorption column in patients septic shock and endotoxemia. The therapy was guided by a new bedside method measuring activity (EA). Intensive care unit (ICU) suspected Gram-negative infection were consecutively added to study group within first 24 h. Endotoxin performed using hemoperfusion Alteco LPS Adsorber. primary endpoint improvement organ function h treatment. A secondary objective assess usefulness EA help guide therapy....
The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an impact on course COVID-19, play a role in clinical outcome disease. Here, we performed comprehensive analysis peripheral blood lymphocyte subpopulations 82 patients with including 31 critical In COVID-19 who required hospitalization analyzed T cell subsets, Treg cells, as well TCRα/β γ/δ, NK B during first two weeks after admission hospital due infection, marked reductions leukocytes subpopulations, especially...
Abstract Background In Poland, the clinical characteristics and outcomes of patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) remain unknown. This study aimed to answer these unknowns by analyzing data collected from high-volume ECMO centers willing participate in this project. Methods retrospective, multicenter cohort was completed between March 1, 2020, May 31, 2021 (15 months). Data all treated for were analyzed. Pre-ECMO laboratory treatment compared...
Despite restrictions, mercury continues to pose a health concern. Mercury has the ability deposit in most parts of body and can cause wide range unspecific symptoms leading diagnostic mistakes.We report case severe vapour poisoning after occupational exposure chloralkali plant worker that resulted life-threatening respiratory failure, pneumomediastinum quadriparesis.Prolonged mechanical ventilation treatment with penicillamine spironolactone was used successful outcome.
To examine the effect of endotoxemia on procalcitonin (PCT) serum levels and mortality rates adult patients with septic shock diagnosed day admission to intensive care unit (ICU). A retrospective observational study was performed over a 2-year period. Levels PCT were compared for without ICU. Endotoxemia identified an Endotoxin Activity Assay. One hundred fifty-seven enrolled into study. Group 1 consisted elevated endotoxin activity (EA) (n = 95, EA 0.57 [EAU] [0.46–0.67]) 2 low 62, 0.27 EAU...
Severe viral infections often result in abnormal platelet function, affecting various stages of hemostasis. Activated platelets are considered prothrombotic and more susceptible to further stimulation. However, emerging evidence suggests that initial hyperactivation is followed by exhaustion hypo-responsiveness, degranulation, activation, aggregation. We examined early alterations aggregation among patients (N = 28) with acute respiratory distress syndrome SARS-CoV-2 infection who were...
MDR/XDR constitutes a difficult to treat bacteria in number of infections as there are few therapeutic options. Promising drugs such cases can be cefiderocol, aztreonam and ceftazidime/avibactam or meropenem/vaborbactam.
Antibiotic use and microbial resistance in health care-associated infections are increasing globally causing care problems. Intensive Care Units (ICUs) represent the heaviest antibiotic burden within hospitals, sepsis is second noncardiac cause of mortality ICUs. Optimizing appropriate treatment management critically ill ICUs became a major challenge for intensivists. We performed surveillance study on consumption 108 Polish determined which classes antibiotics were most commonly consumed...
Endotoxin, a component of the outer membrane Gram-negative bacteria, is considered an important factor in pathogenesis septic shock [1]. The aim our study was to determine whether endotoxin elimination treatment added standard would improve organ function patients with shock.
The development of targeted biological therapies for coronavirus disease 2019 (COVID-19) requires reliable biomarkers that could help indicate how patients are responding. hyperactivation inflammasomes by the SARS-CoV2 virus is hypothesized to contribute a more severe course COVID-19 disease. Therefore, we aimed evaluate prognostic value several inflammasome-related cytokines and proteins upon admission intensive care unit (ICU).We performed prospective cohort study. Plasma samples were...
Prolonged support of organ functions without therapeutic benefit represents a serious problem therapy in intensive care units (ICUs). This kind treatment, called "futile therapy", prolongs the process dying and should be avoided. In Poland, guidelines protocol defining best clinical practice for avoidance futile ICUs was published 2014. The aim study to analyse protocols concerning general ICU University Hospital Wrocław, Poland during years 2015-2018.The content analysed. contained...
Endotoxin is considered a key signaling molecule in the pathogenesis of sepsis and septic shock. Anti-endotoxin therapies may result improvement patient's clinical condition lower mortality. The pressing challenge to identify patients for whom endotoxin elimination would be most beneficial. An activity assay (EAA) has been available detection endotoxins, allowing selection at high risk endotoxemia intensive care units (ICUs). We studied cohort 172 consecutive who had shock on admission ICU....
Background: This study compares organ dysfunction, treatment strategies, and unfavorable outcome rates between pregnant nonpregnant women admitted to the ICU with severe COVID-19, highlighting increased susceptibility of respiratory infections due physiological changes. Methods: A retrospective, age-matched was conducted at a referral center specializing in critical care for women. Data from 14 pregnant/postpartum 11 were analyzed admission on days 3, 5, 7. Results: Acute distress syndrome...
Abstract Background In Poland, little is known about the most serious cases of influenza that need admittance to intensive care unit (ICU), as well use extracorporeal respiratory support. Methods This was an electronic survey comprising ICUs in two administrative regions Poland. The aim study determine number patients with failure admitted ICU autumn–winter season 2018/2019. Furthermore, support, outcome and other pathogens detected airways were investigated. Results Influenza infection...
Abstract Purpose Development of targeted biological therapies for COVID-19 requires reliable biomarkers that could help indicate the responding patients. Hyperactivation inflammasome by SARS-CoV2 virus is hypothesized to contribute severe course disease. Therefore, we aimed evaluate prognostic value several inflammasome-related cytokines and proteins at admission intensive care unit (ICU). Patients methods Plasma samples were obtained from 45 critically ill patients 10 any without signs...
Endotoxin, a key component on the outer membrane of Gram-negative bacteria, is considered to be most important toxin involved in development septic shock, and procalcitonin (PCT) serum concentration has been strongly associated with severity sepsis. The effect elevated endotoxin activity (EA) PCT level, organ function mortality patients shock was evaluated day admission ICU.
Background: In the Resolution 70.7 in 2017, World Health Assembly urged member states to integrate sepsis their national health systems. May 2022, G7 Ministers reiterated necessity implement such resolution focusing on early detection, diagnosis, and therapy. Defining implementing standards established guidelines, infrastructure, laboratory capacity, strategies should be fundamental elements of any plan. Up now, no data exist describing current state care, availability diagnostics or...