A5000119234- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Nosocomial Infections in ICU
- Inflammasome and immune disorders
- Intracranial Aneurysms: Treatment and Complications
- Central Venous Catheters and Hemodialysis
- Infection Control in Healthcare
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Building materials and conservation
- Musculoskeletal synovial abnormalities and treatments
- Nitric Oxide and Endothelin Effects
- Non-Invasive Vital Sign Monitoring
- Bone Tumor Diagnosis and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Immune Response and Inflammation
- Sarcoma Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Neurosurgical Procedures and Complications
- Respiratory Support and Mechanisms
- Thermoregulation and physiological responses
- Inhalation and Respiratory Drug Delivery
- Platelet Disorders and Treatments
Wroclaw Medical University
2019-2024
The SARS-CoV-2 virus alters the expression of genes for extracellular matrix proteins, including fibronectin. aim study was to establish relationship between different forms fibronectin, such as plasma (pFN), cellular (EDA-FN), and proteolytic FN-fragments, disease severity mortality critically ill patients treated in intensive care unit. levels pFN, EDA-FN, FN-fragments were measured with a viral (N = 43, COVID-19) or bacterial 41, sepsis) infection, using immunoblotting ELISA. level but...
Pneumonia is a common complication of hospitalisation in severely ill patients who need mechanical ventilation. The aim this study was to assess the usefulness International Nosocomial Infection Control Consortium programme for surveillance ventilator-associated pneumonia (VAP).A prospective (1 Jan 2012-30 June 2014) conducted 20-bed ICU. device utilisation ratios lung ventilation and frequency (density incidence) aetiology VAP were estimated ICU patients.From total 1097 patients, infections...
Severe viral infections often result in abnormal platelet function, affecting various stages of hemostasis. Activated platelets are considered prothrombotic and more susceptible to further stimulation. However, emerging evidence suggests that initial hyperactivation is followed by exhaustion hypo-responsiveness, degranulation, activation, aggregation. We examined early alterations aggregation among patients (N = 28) with acute respiratory distress syndrome SARS-CoV-2 infection who were...
In this preliminary study we investigated the relationship between time of cerebral desaturation episodes (CDEs), severity haemorrhage, and short-term outcome in patients with aneurysmal subarachnoid haemorrhage (aSAH). Thirty eight patents diagnosed were analysed study. Regional oxygenation (rSO2) was assessed using near infrared spectroscopy (NIRS). A CDE defined as rSO2 < 60% a duration at least 30 min. The aSAH Hunt Hess scale evaluated utilizing Glasgow Outcome Scale. CDEs found 44%...
The development of targeted biological therapies for coronavirus disease 2019 (COVID-19) requires reliable biomarkers that could help indicate how patients are responding. hyperactivation inflammasomes by the SARS-CoV2 virus is hypothesized to contribute a more severe course COVID-19 disease. Therefore, we aimed evaluate prognostic value several inflammasome-related cytokines and proteins upon admission intensive care unit (ICU).We performed prospective cohort study. Plasma samples were...
Abstract Background The observation of tympanic membrane displacement (TMD) opens up the possibility indirect intracranial pressure (ICP) estimation. In this study, we applied a phase-based video motion magnification (VMM) algorithm to reveal spontaneous pulse TMD waveforms (spTMD) and compare them with invasively measured ICP in patients pathologies. Methods Nine adults (six traumatic brain injury three aneurysmal subarachnoid haemorrhage; median age 44 (29–53) years admitted intensive care...
The role of inhaled nitric oxide in the treatment shock remains controversial and further translational research is needed. Long-term observation studies using a model endotoxin-induced to assess effect on platelet aggregation have not yet been reported.The tests were carried out an animal two 10-h periods. During first 10 h, endotoxin was infused inhibition evaluated; following termination infusion, restoration assessed for h. A total 30 pigs used (NO group, N = 14; control, 16). In NO...
Blood coagulation disorders in patients with intracranial bleeding as a result of head injuries or ruptured aneurysms are diagnostic and therapeutic problem appropriate assessments needed to limit CNS damage implement preventive measures. The aim the study was monitor changes platelet aggregation assess importance dysfunction for predicting survival. Platelet receptor function analysis performed using agonists arachidonic acid (ASPI), adenosine diphosphate (ADP), collagen (COL), thrombin...
Zakażenia krwi związane z dostępem naczyniowym są poważnym, ale potencjalnie możliwym do zredukowania powikłaniem szpitalnym u ciężko chorych pacjentów. Od 01.01.2012 30.06.2014 roku prowadzono prospektywne badanie w 20-łóżkowym oddziale intensywnej terapii (OIT ) Uniwersytetu Medycznego we Wrocł
Abstract Purpose Development of targeted biological therapies for COVID-19 requires reliable biomarkers that could help indicate the responding patients. Hyperactivation inflammasome by SARS-CoV2 virus is hypothesized to contribute severe course disease. Therefore, we aimed evaluate prognostic value several inflammasome-related cytokines and proteins at admission intensive care unit (ICU). Patients methods Plasma samples were obtained from 45 critically ill patients 10 any without signs...
Introduction: Cancer of the patella is a rare condition. Giant cell tumor an extremely and difficult to solve therapeutic problem. Depending on degree bone destruction, it may cause significant knee joint dysfunction. It assumed that surgery treatment choice. Material/Methods: This study presents innovative giant in 40-year-old male with dysfunction extensor mechanism. Complex therapy included neoadjuvant using human monoclonal antibody IgG2 binds RANKL (Denosumab) follow-up allogeneic...