A5071813305- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- Clinical Nutrition and Gastroenterology
- Respiratory Support and Mechanisms
- Frailty in Older Adults
- S100 Proteins and Annexins
- Infant Nutrition and Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pancreatitis Pathology and Treatment
- Cell Adhesion Molecules Research
- Intracranial Aneurysms: Treatment and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Extracellular vesicles in disease
- COVID-19 epidemiological studies
- Heart Failure Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Neonatal Respiratory Health Research
- Inflammation biomarkers and pathways
- Thermal Regulation in Medicine
- COVID-19 and Mental Health
Wroclaw Medical University
2015-2025
John Paul II Hospital
2024
Medical University of Lublin
2024
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2021
Assistance Publique – Hôpitaux de Paris
2021
Inserm
2021
Sorbonne Université
2021
National Institutes of Health
2005-2008
National Heart Lung and Blood Institute
2006-2008
University of Wrocław
2000
Abstract On the basis of a semi-realistic SIR microsimulation for Germany and Poland, we show that R 0 parameter interval which COVID-19 epidemic stays overcritical but below capacity limit health care system to reach herd immunity is so narrow successful implementation this strategy likely fail, in contrast results obtained from classical differential equation models. Our based on official census data involves household composition age distribution as main population structure variables....
Gastrointestinal (GI) failure can be both a cause of sepsis and consequence the systemic pro-inflammatory response in sepsis. Changes biomarkers enterocyte damage, citrulline I-FABP (intestinal fatty acid binding protein), may indicate altered intestinal permeability damage. The study group consisted patients with (N = 28) septic shock 30); control included without infection 10). Blood samples were collected for 4-point AGI score (acute GI injury score) was calculated to monitor function on...
Extracellular tumor necrosis factor (TNF) receptors function as TNF-binding proteins that modulate TNF activity. In human vascular endothelial cells (HUVEC), extracellular TNFR1 (type I receptor, TNFRSF1A) is generated by two mechanisms, proteolytic cleavage of soluble ectodomains and the release full-length 55-kDa in membranes exosome-like vesicles. from HUVEC known to involve association between ARTS-1 (aminopeptidase regulator shedding), an integral membrane aminopeptidase, TNFR1. The...
To evaluate the effectiveness of endotoxin elimination with an adsorption column in patients septic shock and endotoxemia. The therapy was guided by a new bedside method measuring activity (EA). Intensive care unit (ICU) suspected Gram-negative infection were consecutively added to study group within first 24 h. Endotoxin performed using hemoperfusion Alteco LPS Adsorber. primary endpoint improvement organ function h treatment. A secondary objective assess usefulness EA help guide therapy....
Patients with heart failure (HF) are at high risk of unfavorable courses COVID-19. The aim this study was to evaluate characteristics and outcomes COVID-19 patients HF.Data hospitalized in a tertiary hospital Poland between March 2020 May 2021 laboratory-confirmed were analyzed. population divided into HF group (patients history HF) non-HF group.Out 2184 (65 ± 13 years old, 50% male), 12% had HF. from the older, more often males, comorbidities, dyspnea, pulmonary peripheral congestion,...
Objective and Design The soluble urokinase plasminogen activator receptor (suPAR) has been recently recognized as a potential biological marker of various disease states, but the impact major surgical intervention on suPAR level not yet established. aim our study was to investigate if induction systemic inflammatory reaction in response cardiopulmonary bypass would be accompanied by an increase plasma level. Methods Subjects Patients undergoing coronary artery grafting under (CPB) were...
The aim of this study was to monitor the development coagulation abnormalities in patients with severe sepsis using thromboelastometry and assess whether increased endotoxin activity associated a change coagulation. Data collected on ICU admission, day 2, 3, 4 were analysed 61 patients. Thromboelastometry made it possible identify normal (group 1), hypercoagulable 2), or hypocoagulable 3) pattern. best accuracy parameters as potential indices yielded by clot formation time maximum firmness....
The Nutrition Risk in Critically Ill score (NUTRIC) is an important nutritional risk assessment instrument for patients the intensive care unit (ICU). purpose of this study was to evaluate power predict mortality treated sepsis and forecast increased resource utilization nursing workload ICU. NUTRIC predicted (AUC 0.833, p < 0.001) with optimal cut-off value 6 points. Among a ≥ on ICU admission, 28-day 61%, 10% (p 0.001). In addition, ≥6 associated more intense use resources, as evidenced by...
Abstract One of the major pathomechanisms COVID-19 is interplay hyperinflammation and disruptions in coagulation processes, involving thrombocytes. Antiplatelet therapy (AP) by anti-inflammatory effect inhibition platelet aggregation may affect these pathways. The aim this study was to investigate if AP has an impact on in-hospital course medium-term outcomes hospitalized patients. population (2170 patients: mean ± SD age 60 19 years old, 50% male) divided into a group 274 patients receiving...
The increasing population of very old intensive care patients (VIPs) is a major challenge currently faced by clinicians and policymakers. Reliable indicators VIPs' prognosis purposefulness their admission to the unit (ICU) are urgently needed.This report from Polish sample VIP1 multicentre cohort study (NCT03134807). Patients ≥ 80 years age admitted ICU were included in study. Information on type reason for admission, demographics, utilisation procedures, length stay, organ dysfunction...
The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an impact on course COVID-19, play a role in clinical outcome disease. Here, we performed comprehensive analysis peripheral blood lymphocyte subpopulations 82 patients with including 31 critical In COVID-19 who required hospitalization analyzed T cell subsets, Treg cells, as well TCRα/β γ/δ, NK B during first two weeks after admission hospital due infection, marked reductions leukocytes subpopulations, especially...
Gastrointestinal symptoms are common in critically ill COVID-19 patients. There is currently no generally recognized method of assessing gastrointestinal injury unconscious or sedated intensive care unit (ICU) I-FABP (intestinal fatty acid binding protein) and citrulline have previously been studied as potential biomarkers enterocyte damage various tract diseases, changes the levels these markers may reflect intestinal wall COVID-19. Patients with critical COVID-19, diagnosed sepsis, septic...
Abstract Background Subarachnoid bleeding is associated with brain injuries and ranges from almost negligible to acute life threatening. The main objectives were study changes in brain-specific biomarker levels patients after an aneurysmal subarachnoid hemorrhage (aSAH) relation early clinical findings, severity scores, intensive care unit (ICU) outcome. Analysis was done identify specific biomarkers as predictors of a bad outcome the treatment phase. Methods performed for proteins...
Severe sepsis remains the most common cause of death in intensive care units (ICUs) according to many epidemiological studies. There are no data Poland on extent severe cases treated ICUs. The aim study was analyse course and outcome patients Polish ICUs.In 2003, internet-based registry created as a multicentre observational research project. An online questionnaire made accessible ICUs participating study. Questionnaires were completed after discharge included demographic data, clinical...
TNF-alpha-converting enzyme (TACE, ADAM17) cleaves membrane-associated cytokines and receptors thereby regulates inflammatory immune events, as well lung development mucin production. For example, the TACE-mediated cleavage of type II 75-kDa TNF receptor (TNFR2) generates a soluble TNF-binding protein that modulates bioactivity. TACE is synthesized latent proenzyme retained in an inactive state via interaction between its prodomain catalytic domain. Although formation intramolecular bond...
Delirium is a common complication after cardiac surgery.The aim of our study was to determine the impact hyperoxia episodes occurring during cardiopulmonary bypass (CBP) on rate delirium in postoperative period.93 patients, aged ≥ 65, who underwent elective surgery (CBP <90 minutes) were enrolled.The occurrence examined every 12 hours for three days surgery.Eleven patients (11.8%) developed (POD (+)) and 83 did not (-)).More incidences severe (PaO2 26.6kPa) CBP observed POD (+) group: 64%...
The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior COVID-19 infection may impact clinical profile, as well mortality rate among patients hospitalized with COVID-19. study was based on retrospective analysis medical records laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group 236 receiving any anticoagulant treatment (AT group) compared without...