A5043234737- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- Metabolomics and Mass Spectrometry Studies
- Reproductive tract infections research
- S100 Proteins and Annexins
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Inflammasome and immune disorders
- Sexual function and dysfunction studies
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Heat shock proteins research
- Neonatal and Maternal Infections
- Cancer, Stress, Anesthesia, and Immune Response
- Bacteriophages and microbial interactions
- Clusterin in disease pathology
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Neurotransmitter Receptor Influence on Behavior
- Machine Learning in Bioinformatics
- Antibiotic Resistance in Bacteria
- Cannabis and Cannabinoid Research
- Cancer Research and Treatments
- Gut microbiota and health
- Protease and Inhibitor Mechanisms
Wroclaw Medical University
2013-2022
Heat shock proteins HSPA1/Hsp70α and HSP90AA1/Hsp90α are crucial for cancer growth but their expression pattern in colorectal polyps or whether they can be modulated by oxicams is unknown. We quantified (RTqPCR) HSPA1 HSP90AA1 50 polyp-normal pairs relation to polyp malignancy potential examined the effect of piroxicam, meloxicam five novel analogues on (mRNA/protein) adenocarcinoma lines. were upregulated 3- 2.9-fold. Expression ratios higher with dysplasia grade dominant villous pattern,...
L-arginine/nitric oxide pathway metabolites are altered in colorectal cancer (CRC). We evaluated underlying changes enzymes 55 paired tumor/tumor-adjacent samples and 20 normal mucosa using quantitative-PCR assessed the impact of classic novel oxicam analogues on enzyme expression intracellular metabolite concentration (LC-MS/MS) Caco-2, HCT116, HT-29 cells. Compared to mucosa, ARG1, PRMT1, PRMT5 were overexpressed both tumor tumor-adjacent tissue DDAH2 solely tissue. Tumor-adjacent had...
The endocannabinoid system (ECS) is composed of cannabinoid receptors type 1 (CBR1) and 2 (CBR2), cannabinoid-based ligands (endogenous chemically synthesized phytocannabinoids), endogenous enzymes controlling their concentrations. Cannabinoid (CBRs) have been identified in invertebrates almost all vertebrate species the central peripheral nervous as well immune cells, where they control neuroimmune homeostasis. In humans, rodents, dogs, cats, CBRs expression has confirmed skin, tissue...
Sepsis, defined as a dysregulated host response to infection, causes the interruption of homeostasis resulting in metabolic changes. An examination patient metabolites, such amino acids, during early stage sepsis may facilitate diagnosing and assessing severity sepsis. The aim this study was compare patterns urine serum acids relative sepsis, septic shock survival. Urine samples were obtained from healthy volunteers (n = 15) once or patients within 24 h diagnosis shock. Concentrations 25...
Many models assessing the risk of sepsis utilize knowledge constituents plasminogen system, as it is proven that some species bacteria can activate plasminogen, a result interactions with bacterial outer membrane proteins. However, much yet to be discovered about this interaction since there little information regarding species. This study aimed check if Klebsiella pneumoniae, one major factors nosocomial pneumonia and factor for severe sepsis, has ability bind human plasminogen. The strain...
Background.Enolase is generally known as the glycolytic pathway enzyme present in cytoplasm of eukaryotic cells and some microorganisms.In human cells, it also a component cell surface membranes, where functions plasminogen receptor.Objectives.The study aimed to purify Salmonella enterica serovar Typhimurium cytosolic enolase obtain antibodies against this protein; identify on bacteria; find cross-reactivity binding properties.Material methods.Cytosolic from S. was purified using five-step...