A5017540096- Cancer, Stress, Anesthesia, and Immune Response
- Biochemical and Structural Characterization
- Protein Hydrolysis and Bioactive Peptides
- Cancer, Hypoxia, and Metabolism
- Lysosomal Storage Disorders Research
- Health Promotion and Cardiovascular Prevention
- Antimicrobial Peptides and Activities
- Social Issues in Poland
- Education and Cultural Studies
- Health, psychology, and well-being
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Immune Cell Function and Interaction
- Essential Oils and Antimicrobial Activity
- Photosynthetic Processes and Mechanisms
- Oral microbiology and periodontitis research
- Global Health Care Issues
- Phytochemistry and Biological Activities
- Calcium signaling and nucleotide metabolism
- Inflammatory Biomarkers in Disease Prognosis
- European Politics and Security
- Cellular transport and secretion
- European and International Law Studies
- Plant biochemistry and biosynthesis
- Oral and gingival health research
Wroclaw Medical University
2020-2022
Radom (Czechia)
2015
King's College London
2013
Kings Health Partners
2013
University of Wrocław
2007-2009
Juvenile neuronal ceroid lipofuscinosis (JNCL or CLN3 disease) is an autosomal recessive lysosomal storage disease resulting from mutations in the gene that encodes a membrane protein. The primarily affects brain with widespread intralysosomal accumulation of autofluorescent material and fibrillary gliosis, as well loss specific populations. As experimental treatment for CNS manifestations JNCL, we have developed serotype rh.10 adeno-associated virus vector expressing human cDNA...
L-arginine/nitric oxide pathway metabolites are altered in colorectal cancer (CRC). We evaluated underlying changes enzymes 55 paired tumor/tumor-adjacent samples and 20 normal mucosa using quantitative-PCR assessed the impact of classic novel oxicam analogues on enzyme expression intracellular metabolite concentration (LC-MS/MS) Caco-2, HCT116, HT-29 cells. Compared to mucosa, ARG1, PRMT1, PRMT5 were overexpressed both tumor tumor-adjacent tissue DDAH2 solely tissue. Tumor-adjacent had...
Guidelines on cardiovascular prevention from the European Society of Cardiology advocate sustained educational measures to be undertaken by both doctors and nurses ensure lifestyle changes for patients after acute coronary syndromes (ACS). A planned programme a series meetings ACS was initiated in form Patient Club.To assess efficacy Club initiative terms increased knowledge risk factors as well utilisation healthy patents who attend programme.Patients nine cardiology centres Poland, were...
Immunosuppressive interleukins (IL)-4 and 13 may directly promote cancer but neither their status nor role in gastrointestinal tract is clarified. We aim at quantifying ILs receptors paired normal-tumor samples (n = 49/51) sera 263), using immunoassays RTqPCR, screening for effect on colonic cells. Both were elevated locally protein level all cancers only IL13 transcripts colon upregulated. Interleukin receptor expression reflected pathology to varying degrees, with the association...
Despite the fact that phytochemicals of Cornaceae species have long been discussed as possible auxiliary agents in contemporary treatment, insights on their properties remain relatively scarce. This study focuses Cornus mas L. (Cornelian cherry), extracts which are reported to exert a pleiotropic effect shown both vivo and vitro studies. aimed explore cytotoxic from fruits red (Cornus 'Podolski') yellow 'Yantarnyi' 'Flava') Cornelian cherries two melanoma cell lines (A375 MeWo). The were...
The L-Arginine/NO pathway is involved in carcinogenesis and immunity. Its diagnostic prognostic value colorectal cancer (CRC) was determined using tandem mass spectrometry 199 individuals (137 with CRC) and, during a three-day follow up, 60 patients undergoing surgery. Citrulline decreased asymmetric (ADMA) symmetric (SDMA) dimethylarginines dimethylamine (DMA) were increased CRC. DMA increase corresponded CRC advancement while arginine, ADMA, SDMA levels higher left-sided cancers. Arginine,...
The increasing incidence of fungal infections together with the emergence strains resistant to currently available antifungal drugs calls for development new classes antimycotics. Naturally occurring proteins and peptides are interest because low toxicity, immunomodulatory potential mechanisms action distinct from those drugs. In this study, potent activity cystatin, affinity-purified chicken egg white (CEWC), against most frequent human pathogens genus Candida was identified characterised....
Porphyromonas gingivalis has been implicated as the major pathogen of periodontitis in adults. This organism produces an array virulence factors, which cysteine proteinases, referred to gingipains K and R, are believed play a crucial role pathogenicity. The aim this study was investigate susceptibility R inhibition by pancreatic secretory trypsin inhibitor.Enzyme activities were measured spectrophotometrically using chromogenic turnover substrates. To estimate value association constant...