A5063126619- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Heart Failure Treatment and Management
- Healthcare and Venom Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrest and Resuscitation
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- GDF15 and Related Biomarkers
- Cardiovascular Function and Risk Factors
- Helicobacter pylori-related gastroenterology studies
- Insect and Pesticide Research
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Mechanical Circulatory Support Devices
- Blood Pressure and Hypertension Studies
- Biochemical Analysis and Sensing Techniques
- Potassium and Related Disorders
- Climate Change and Health Impacts
- Dermatology and Skin Diseases
Wroclaw Medical University
2012-2024
University of Wrocław
2020-2023
Individuals with a history of allergy are potentially at risk suffering from adverse effects after COVID-19 vaccination. We sought to assess the tolerance towards Pfizer-BioNTech vaccine in allergic patients. To address this issue, we used questionnaire conducted on-line group medical professionals who were vaccinated vaccine. A total 1808 respondents, out whom 1707 received two doses vaccine, returned questionnaire. Local reactions injection more frequent individuals both (swelling p =...
There is controversy whether taking β-blockers or ACE inhibitors (ACEI) a risk factor for more severe systemic insect sting reactions (SSR) and it increases the number severity of adverse events (AE) during venom immunotherapy (VIT).In this open, prospective, observational, multicenter trial, we recruited patients with history SSR indication VIT. The primary objective study was to evaluate ACEI show AE VIT compared without such treatment.In total, 1,425 were enrolled performed in 1,342...
The safety of simultaneous vaccination for Respiratory Syncytial Virus (RSV) and influenza in vulnerable high-risk heart failure (HF) patients remains unclear. In an open-label, prospective study, 105 received concurrent (Vaxigrip Tetra, season 2023/2024, Sanofi) RSV (Arexvy, GSK) vaccinations from September 15th to November 17th, 2023. Adverse events were collected on the fourth-day post-vaccination. Overall, was well tolerated, with most common reaction being injection site pain (63 %)....
Patients with heart failure (HF) are at high risk of unfavorable courses COVID-19. The aim this study was to evaluate characteristics and outcomes COVID-19 patients HF.Data hospitalized in a tertiary hospital Poland between March 2020 May 2021 laboratory-confirmed were analyzed. population divided into HF group (patients history HF) non-HF group.Out 2184 (65 ± 13 years old, 50% male), 12% had HF. from the older, more often males, comorbidities, dyspnea, pulmonary peripheral congestion,...
Although renin-angiotensin-aldosterone system (RAAS) activation is believed to be the major driver of acute heart failure (AHF) episodes our understanding its prevalence and clinical relevance in contemporary settings incomplete.Serum renin aldosterone were measured at day-1 discharge patients (n = 211) that hospitalized between 2016 2017 for AHF a single cardiology center. The population was profiled based on upper limits normal (ULN) both biomarkers assessed linked with course outcomes.The...
The ultrarush protocol is an attractive approach in the buildup phase of venom immunotherapy (VIT-UR). However, degree risk VIT-UR children remains unknown. objective this study was to compare safety and adults.We performed a based on prospectively gathered medical records adults with hymenoptera allergy treated 3 centers Poland.The population comprised 134 (mean [SD] age, 12.6 [3.7] years; males, 70.1%) 207 42.4 [14.0] 47.8%). number subgroups bee (BV) wasp (WV) were comparable, although...
COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk an unfavorable course COVID-19. The endothelial activation and stress index (EASIX) score has been used simple predictor overall survival (OS) in specific groups cancer EASIX, biomarker dysfunction, might play prognostic role patients Here, we performed comprehensive retrospective analysis...
The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior COVID-19 infection may impact clinical profile, as well mortality rate among patients hospitalized with COVID-19. study was based on retrospective analysis medical records laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group 236 receiving any anticoagulant treatment (AT group) compared without...
The perception of acute heart failure (AHF) as a single entity is increasingly outdated, distinct patient profiles can be discerned. Key (HF) studies have previously highlighted the difference in both course and prognosis de novo AHF decompensated chronic HF (ADHF). Accordingly, with differing underlying pathophysiologies disease progression shown. We compared range selected biomarkers order to better describe profile ADHF, including inter alia—serum lactate, bilirubin, matrix...
Insect venom is one of the most common triggers anaphylaxis in elderly population. Venom immunotherapy (VIT) remains only treatment for Hymenoptera allergy (HVA). However, little known about differences indication VIT group patients aged 60 years and older. The objective this study was to assess clinical diagnostic HVA patients. compared data from ≥ (N = 132) 11 750) terms severity, comorbidities, immunological parameters, namely, intradermal testing (IDT), specific IgE (sIgE) levels against...
Abstract The aim of this research was to examine the prevalence hyperventilation (defined by pCO 2 value) among acute heart failure (AHF) patients and link it with potential triggers prognosis. All underwent dyspnea severity assessment capillary blood examination on hospital admission during hospitalization. Out 241 AHF patients, 57(24%) were assigned low group (pCO ≤ 30 mmHg) 184 (76%) normal > mmHg). Low had significantly lower HCO 3 - (22.3 ± 3.4 vs 24.7 2.9 mmol/L, p < 0.0001)...
Among the potential hazards of HDM immunotherapy (AIT) with allergenic extracts is possible initiation de novosensitizations caused by a lack complementarity between given vaccine's content and patient's molecular sensitization profile. To investigate whether affects changes in profile sensitizations to allergens contained extract neosensitizations occur. Serum samples from patients allergies (N=63) who received 1 year treatment subcutaneous AIT were tested for allergen-specific IgE (sIgE)...
Venom immunotherapy (VIT) is the only efficient therapy for Hymenoptera insect venom allergy. Immunotherapy with bee encumbered a higher risk of systemic side effects and/or therapeutic failures. The objective study was to assess if specific profiles molecular IgE (Immunoglobulin E) responses are associated an increased treatment’s inefficacy. group numbered 64 allergic patients (BVA) who received modo ultra-rush (VIT-UR), (f/m: 32/32, mean age 43.4 ± 17.2). In total, 54.84% them manifested...
To perform a genome-wide characterization of changes in microRNA (miRNA) expression during the course venom immunotherapy (VIT).miRNA was isolated from whole-blood 13 allergic patients and 14 controls, who experienced no reaction upon stings by honeybees wasps. We analyzed 2549 miRNAs whole blood these prior to VIT 12 months after start VIT. The results for differential obtained on microarray platform were confirmed quantitative real-time PCR. Out patients, 8 had negative with VIT, thus...
Abstract Aim. The aim of this research was to examine the prevalence hyperventilation (defined by pCO 2 value) among acute heart failure (AHF) patients and link it with potential triggers prognosis. Methods. AHF underwent multidirectional assessment including capillary blood gas examination on hospital admission during hospitalization. Results. Out 241 patients, 57(24%) were assigned low group (pCO > 30mmHg) 184 (76%) normal 30mmHg). Low had significantly lower HCO 3 - (22.3 ± 3.4 mmol/L...
The safety profile of venom immunotherapy (VIT) is a relevant issue and considerable differences in efficacy VIT have been reported. primary aim this study was to evaluate the ACE inhibitors beta-blockers during VIT, which has already published. For second analysis, data concerning premedication preparations relation systemic adverse events (AE) up-dosing phase first year maintenance were evaluated as well outcome field stings sting challenges.The conducted an open, prospective,...
Background: There is controversy whether taking β-blockers or ACE inhibitors (ACEI) a risk factor for more severe systemic insect sting reactions (SSR) and it increases the number severity of adverse events (AE) during venom immunotherapy (VIT). Methods: In this open, prospective, observational, multicenter trial, we recruited patients with history SSR indication VIT. The primary objective study was to evaluate ACEI show AE VIT compared without such treatment. Results: total, 1,425 were...