A5061999948- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Healthcare and Venom Research
- Insect and Pesticide Research
- Entomological Studies and Ecology
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Bee Products Chemical Analysis
- Mast cells and histamine
- Dermatology and Skin Diseases
- Toxin Mechanisms and Immunotoxins
Medical University of Graz
2019-2025
Abstract Background In patients who require venom immunotherapy (VIT), there is a need to identify underlying mast cell (MC) disorders since these may affect the risk and severity of future sting reactions long‐term effectiveness VIT. Methods 1319 individuals with Hymenoptera allergy (HVA) needed VIT from referral centers in Slovenia, Austria, Croatia, Poland underwent examination for KIT p.D816V peripheral blood leukocytes (PBL) using highly sensitive PCR test tryptase genotyping by digital...
There is controversy whether taking β-blockers or ACE inhibitors (ACEI) a risk factor for more severe systemic insect sting reactions (SSR) and it increases the number severity of adverse events (AE) during venom immunotherapy (VIT).In this open, prospective, observational, multicenter trial, we recruited patients with history SSR indication VIT. The primary objective study was to evaluate ACEI show AE VIT compared without such treatment.In total, 1,425 were enrolled performed in 1,342...
Abstract Insect venom allergy is the most frequent cause of anaphylaxis in Europe and possibly worldwide. The majority systemic allergic reactions after insect stings are caused by Hymenoptera, among these, vespid genera induce sting (SSR). Honey bees second leading SSR. Depending on global region, other Hymenoptera such as different ant responsible for Widely distributed hornets bumblebees or local bee rarely Hematophagous insects mosquitoes horse flies usually (large) while SSR...
Abstract Background The specificity of extract‐based pollen allergy diagnosis is decreased due to cross‐reactivity via cross‐reactive carbohydrate determinants (CCDs) or panallergens such as profilins polcalcins. This study aimed explore the prevalence sensitization seasonal extracts, CCDs, profilin and polcalcin investigate sensitivity molecular (MAD) using commercially available test methods. Methods 2948 patients were screened for specific immunoglobulin E ash, birch, mugwort, ragweed...
An individualized diagnostic approach determining molecular sensitization patterns of house dust mite (HDM) allergic patients may help to identify best eligible for allergen immunotherapy, as modern HDM immunotherapy preparations are usually standardized the major allergens Der p 1, f 2 and 2.1 However, data on reliability allergy diagnosis using commercially available assays limited. We aimed investigate overall sensitivity compared extract-based IgE testing singleplex assay ImmunoCAP...
Background Large local reactions (LLR) to Hymenoptera stings were considered as IgE-mediated late-phase inflammatory reactions. However, in older studies, most patients with LLR skin test positive, but only around 50% had detectable sIgE determined by the RAST system. Methods Data of 620 evaluated retrospectively: 310 who suffered from and previous systemic sting (SSR). We aimed clarify if can generally be detected CAP system LLR; levels clinical parameters compared between SSR. Results...
Hymenoptera venom allergy (HVA) exhibits a wide range of symptoms, which can be mild, such as skin and extend to life-threatening reactions like unconsciousness cardiac arrest. Diagnosis is straightforward in the majority patients, but challenging double positive test negative patients. Test results sometimes confusing patients with high reactivity specific IgE (sIgE) levels are not necessarily at risk for severe systemic sting (SSR), conversely, weakly or even tests experience SSR. Patients...
Venom immunotherapy (VIT) is generally safe and prevents almost all patients from further systemic sting reactions. In recent studies, objective adverse events (AE) were reported in 2.7 to 17.8% of patients.1-3 It well known that AEs occur more frequently during the up-dosing phase bee VIT compared with vespid VIT.1, 4, 5 However, rate was usually analyzed mono-venom or stepwise dual maintaining a 30-min interval between injections venom. A systematic literature research for EAACI guidelines...
Insect venom allergy is the most frequent cause of anaphylaxis in Europe and possibly worldwide. The majority systemic allergic reactions after insect stings are caused by Hymenoptera among these, vespid genera induce sting (SSR). Honey bees second leading SSR. Depending on global region, other such as different ant responsible for Widely distributed hornets bumblebees or local bee rarely Hematophagous insects mosquitoes horse flies usually (large) while SSR occasionally occur. This position...
The safety profile of venom immunotherapy (VIT) is a relevant issue and considerable differences in efficacy VIT have been reported. primary aim this study was to evaluate the ACE inhibitors beta-blockers during VIT, which has already published. For second analysis, data concerning premedication preparations relation systemic adverse events (AE) up-dosing phase first year maintenance were evaluated as well outcome field stings sting challenges.The conducted an open, prospective,...
Background: There is controversy whether taking β-blockers or ACE inhibitors (ACEI) a risk factor for more severe systemic insect sting reactions (SSR) and it increases the number severity of adverse events (AE) during venom immunotherapy (VIT). Methods: In this open, prospective, observational, multicenter trial, we recruited patients with history SSR indication VIT. The primary objective study was to evaluate ACEI show AE VIT compared without such treatment. Results: total, 1,425 were...