A5035632107- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Healthcare and Venom Research
- Insect and Pesticide Research
- Venous Thromboembolism Diagnosis and Management
- Insect and Arachnid Ecology and Behavior
- Toxin Mechanisms and Immunotoxins
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Entomological Studies and Ecology
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Blood groups and transfusion
- Diabetic Foot Ulcer Assessment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacovigilance and Adverse Drug Reactions
- Antimicrobial Peptides and Activities
- Acute Kidney Injury Research
- Shoulder and Clavicle Injuries
- Biotin and Related Studies
- Communication and COVID-19 Impact
- Airway Management and Intubation Techniques
- Autoimmune Bullous Skin Diseases
- Atrial Fibrillation Management and Outcomes
- Signaling Pathways in Disease
Hospital Universitario Reina Sofía
2016-2024
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2024
Instituto de Salud Carlos III
2019-2024
University of Córdoba
2019-2024
Biomedical Research Institute
2016-2020
Hospital General Universitario de Ciudad Real
2015
University of the Basque Country
2013
Université de Bordeaux
1995
There is controversy whether taking β-blockers or ACE inhibitors (ACEI) a risk factor for more severe systemic insect sting reactions (SSR) and it increases the number severity of adverse events (AE) during venom immunotherapy (VIT).In this open, prospective, observational, multicenter trial, we recruited patients with history SSR indication VIT. The primary objective study was to evaluate ACEI show AE VIT compared without such treatment.In total, 1,425 were enrolled performed in 1,342...
Different clinical behaviors have been identified in patients allergic to bee venom. Compound-resolved diagnosis could be an appropriate tool for investigating these differences. The aims of this study were analyze whether specific IgE Api m 4 (sIgE-Api 4) can identify a particular kind venom allergy and describe response immunotherapy (bVIT).Prospective 31 who assigned phenotype group A <0.98 kU/L), treated with native aqueous (NA) extract, or B ≥0.98 purified (PA) extract. Sex, age,...
Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with comprehensive proteomics approach get the annotated olive tree (Olea europaea L.) proteome and define complex allergenome. A total of 1907 proteins were identified by LC–MS/MS using predicted protein sequences from genome. Most (60%) possess catalytic activity be involved in metabolic processes. In total, 203 belonging 47 allergen families found pollen....
Abstract Background Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This nsLTP responsible for severe symptoms in regions with high pollen exposure, where many 7‐sensitized patients exhibit co‐sensitization to peach nsLTP, Pru p 3. However, there no evidence cross‐reactivity, which explains this observed co‐sensitization. Therefore, purpose study was explore relationship between and Methods A total 48 sensitized and/or...
The objective of this study was to list the social vespids occurring in Spain, determine their presence each region, and correlate data with responsible for allergic reactions progression over time.Insects distribution were collected two phases: from southern half Spain (2008-2012), northern (2016-2019). Data prescriptions Hymenoptera venom immunotherapy (HVIT) at six Spanish hospitals years 2009 2019.Polistes dominula Vespula germanica most widely distributed species. Vespa velutina found...
To compare the safety of iopromide and iomeprol use in a hospital that switched from former to latter found an apparent increase number (and different profile) adverse reactions reported for iomeprol, putting its into question.
Inducing tolerance in Hymenoptera-allergic patients, bee venom immunotherapy (BVIT) is a widely accepted method to treat severe allergy stings. In order increase the existing knowledge on underlying immunological mechanisms and look for possible biomarkers predictive of efficacy, group 20 bee-venom-allergic patients (AG) were thoroughly examined during their first year BVIT. addition, results treated with those an untreated tolerant beekeepers (TG) who had previously shown firm...
Aim: Few studies have compared cluster immunotherapy and conventional administration regimens. The aim of this study was to establish the safety profile these different regimens in patients with allergic respiratory diseases who received index-of-reactivity (IR)-standardized allergen extracts by subcutaneous route. Materials & methods: (SCIT), administered means a 4-week titration schedule (cluster-SCIT) or an 8-week short (SC-SCIT), both target dose 8 IR, assessed retrospective,...
Venom immunotherapy (VIT) protects up to 98% of treated Hymenoptera allergy patients from reactions with new stings. A correct diagnosis the identification venom causing allergic reaction is essential implementing it. The knowledge foraging habits when sting takes place in a food environment would allow culprit insect be known. Images occurring environments where there was human were recorded Spain, including date image, description and its geolocation. insects’ genus species identified by...
Although exposure to stings has been identified as the leading risk factor for anaphylaxis due Hymenoptera venom allergy, professional beekeepers receive hundreds of yearly without developing systemic reactions. This study aims analyze mechanisms underlying bee tolerance in beekeepers.A cross-sectional was conducted. Participants were recruited and classified into 3 groups: allergic patients (APs), who experienced reactions after stings, with a positive intradermal test specific IgE (sIgE)...
Summary After the primary response, circulating memory CD4 + T effector and regulatory cells (Treg) regulate recall responses, which are impaired in allergy. Using mass spectrometry, we discovered distinct metabolomes of these humans their unique enrichment amino acids. By assessing energy metabolism vitro ex vivo single-cell analyses, determined that increased intracellular L-phenylalanine boosts glycolysis while limiting OXPHOS T, Th2, but not Treg cells. also restrains proliferation an...
Cross-reactivity between nonspecific lipid transfer proteins could cause anaphylaxis, further influencing food avoidance and nutrient deficiencies. The one affecting olive pollen (Ole e 7) peach (Pru p 3) may underlie a variety of pollen-food syndromes, though deep molecular analysis is necessary.
Background The sting challenge test (SCT) is regarded as the most reliable method for assessing effectiveness of venom immunotherapy (VIT). However, its predictive value in patients undergoing VIT still unclear. This study aims to evaluate SCT. Methods A multicenter retrospective observational was conducted on receiving who underwent gathered data patient demographics, diagnosis, details, outcomes SCT and their comparison subsequent field (FS) results. Results total 261 were included, 372...