A5071919583- Respiratory viral infections research
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Retinal Development and Disorders
- SARS-CoV-2 and COVID-19 Research
- Exercise and Physiological Responses
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- High Altitude and Hypoxia
- Mast cells and histamine
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Respiratory Support and Mechanisms
- T-cell and B-cell Immunology
- Immune cells in cancer
- Inhalation and Respiratory Drug Delivery
University of Zurich
2021-2024
University of Bern
2022
Abstract Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms response to viral in experimental vivo rhinovirus healthy controls patients asthma, vitro experiments mite, SARS-CoV-2 human primary epithelium. Here, we show that leads an excessive RIG-I inflammasome...
Abstract Optogenetic gene therapies to restore vision are in clinical trials. Whilst current approaches target the ganglion cells, output neurons of retina, new molecular tools enable efficient targeting first order retinal interneurons, bipolar with potential a higher quality vision. Here we investigate signaling and behavioral blind mice treated cell targeted optogenetic therapies. All tested tools, including medium-wave opsin, Opto-mGluR6, two melanopsin based chimeras restored visual...
Short-chain fatty acids (SCFAs) produced by the gut microbiota have previously been demonstrated to play a role in numerous chronic inflammatory diseases and be key mediators gut-bone signaling axis. However, of SCFAs bone fracture healing its impact on systemic inflammation during regeneration process has not extensively investigated yet. The aim this study was first determine effects SCFA butyrate cells involved vitro, namely, osteoclasts mesenchymal stromal (MSCs), second, assess if...
Mesenchymal stem cells (mesenchymal stromal cells; MSC)-based therapies remain a promising approach to treat degenerative and inflammatory diseases. Their beneficial effects were confirmed in numerous experimental models clinical trials. However, safety issues concerning MSCs’ stability their long-term limit implementation practice, including treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease, COVID-19. Here, we aimed investigate the intranasal...
Abstract Rhinoviruses (RV) and inhaled allergens, such as house dust mite (HDM) are the major agents responsible for asthma onset, exacerbations progression to severe disease, but mechanisms of these pathogenic reciprocal virus-allergen interactions not well understood. To address this, we analyzed airway epithelial sensing response RV infection using controlled experimental in vivo healthy controls patients with vitro models HDM exposure primary cells. We found that intranasal led highly...
Summary After the primary response, circulating memory CD4 + T effector and regulatory cells (Treg) regulate recall responses, which are impaired in allergy. Using mass spectrometry, we discovered distinct metabolomes of these humans their unique enrichment amino acids. By assessing energy metabolism vitro ex vivo single-cell analyses, determined that increased intracellular L-phenylalanine boosts glycolysis while limiting OXPHOS T, Th2, but not Treg cells. also restrains proliferation an...
Abstract Optogenetic gene therapies to restore vision are in clinical trials. Whilst current approaches target the ganglion cells, output neurons of retina, new molecular tools enable efficient targeting first order retinal interneurons, bipolar with potential a higher quality vision. Here we investigate signaling and behavioral blind mice treated cell targeted optogenetic therapies. All tested tools, including medium-wave opsin, Opto-mGluR6 two melanopsin based chimeras restored visual...
<b>Introduction:</b> Human rhinovirus(RV-A16) plays a major role in exacerbation of asthma. However, there are limited studies revealing metabolic changes this process. We compare response primary airway epithelium from patients with asthma and controls when stimulated RV-A16 to reveal possible relevance pathogenesis virus-induced exacerbations. <b>Methods:</b> bronchial epithelial cells air-liquid interphase or monolayer RV-A16, then examined gene, protein functional by RNA-seq, qPCR,...
Abstract SARS-CoV-2 infection continues to pose a significant life threat, especially in patients with comorbidities. It remains unknown, if asthma or allergen- and virus-induced airway inflammation are risk factors can constitute some forms of protection against COVID-19. ACE2 other SARS-CoV-2-related host proteins limiting an infection, expression which is regulated more complex way than previously anticipated. Hence, we studied the mRNA protein isoforms, together its glycosylation spatial...