A5017176015- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Muscle and Compartmental Disorders
- Systemic Sclerosis and Related Diseases
- Eosinophilic Esophagitis
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Healthcare and Venom Research
- Monoclonal and Polyclonal Antibodies Research
- Contact Dermatitis and Allergies
- Vasculitis and related conditions
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Dermatology and Skin Diseases
- Liver Diseases and Immunity
- Mast cells and histamine
- T-cell and B-cell Immunology
- Bariatric Surgery and Outcomes
University of Córdoba
2019-2024
Instituto de Salud Carlos III
2019-2024
Hospital Universitario Reina Sofía
2015-2024
Instituto Maimónides de Investigación Biomédica de Córdoba
2019-2024
Biomedical Research Institute
2020
Centre Hospitalier Victor Dupouy
2016
Hospital Infanta Margarita
2011
Hospital Universitario de Canarias
2005
Universidad Europea de Canarias
2005
Hospital Doctor José Molina Orosa
2004
The SARS-CoV-2 infection has widely spread to become the greatest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.22%, far higher than those reported in Asia or other European countries. A multicentre retrospective study of demographic, clinical, laboratory and immunological features 584 hospitalized patients their outcomes was...
Because of the involvement nitric oxide (NO) in inflammatory states such as parasitic and hypersensitivity disorders fact that eosinophils are one cell types implicated, we asked whether were able to express mRNA specific inducible NO synthase (iNOS) iNOS protein secrete oxide. was detected on eosinophil preparations by immunocytochemistry using mAb. Expression also immunoblotting human purified an eosinophilic leukemia line, Eol-3. Nitrite production supernatant Eol-3 cells cultured for 24...
Galectin-3 is an animal lectin, formerly named epsilon-binding protein or Mac-2, which has been described to play important role in some inflammatory processes by the implication of different cells and increase cell adhesion functions through laminin binding activity. In this work we analyzed galectin-3 modulation Th2 cytokines that have development response. We found addition human eosinophils, eosinophilic line EoL-3, PBMC, Ag-specific T (CD4+) produced a selective inhibition IL-5...
Increased inflammation is associated with the pathogenesis of heart failure (HF). circulating levels cytokines have been previously reported and generally worse clinical outcomes. In this context, modulation inflammation-related parameters seems to be a reasonable therapeutic option for improving course disease. Based on this, we aimed compare changes in when Mediterranean diet alone or combination hypercaloric, hyperproteic oral nutritional supplements (ONS), enriched omega−3 (n−3)...
Background The amino‐acid and nucleotide sequence of Ole e 1 (the major antigen olive pollen) has been described the IgE antibody response to this allergen was associated with DR7/DQ2 antigens. With previous data we try define T‐cell epitopes implicated in reactivity. Objectives To study recognition T cells (derived from allergic non‐allergic patients) synthetic peptides order immunodominant epitopes. Methods We have compared proliferative peripheral blood mononuclear sensitized patients vs....
Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with comprehensive proteomics approach get the annotated olive tree (Olea europaea L.) proteome and define complex allergenome. A total of 1907 proteins were identified by LC–MS/MS using predicted protein sequences from genome. Most (60%) possess catalytic activity be involved in metabolic processes. In total, 203 belonging 47 allergen families found pollen....
Distinct human leukocyte antigen (HLA)-DQ genes have been associated with an increased or reduced risk for gastric cancer, but its association Helicobacter pylori status is controversial. In the present study we evaluated influence of host HLA DQA1 and DQB1 loci, H. genotype, socio-economic factors on predicting pylori-associated distal cancer in a southern European population.In prospective case-control (1 : 2) study, 42 patients were matched by age (+/-5 years) gender to 84 benign...
Abstract Background Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This nsLTP responsible for severe symptoms in regions with high pollen exposure, where many 7‐sensitized patients exhibit co‐sensitization to peach nsLTP, Pru p 3. However, there no evidence cross‐reactivity, which explains this observed co‐sensitization. Therefore, purpose study was explore relationship between and Methods A total 48 sensitized and/or...
There is increasing evidence about the role of inflammation in sarcopenia and tumor progression; thus, its modulation would represent a valuable strategy for improving clinical outcomes patients with cancer. Several studies have reported that whey protein has significant anti-inflammatory antioxidant characteristics humans. We aimed to evaluate effects protein-based oral nutritional support on circulating cytokines solid tumors undergoing systemic treatment. Forty-six different origin...
Background: Emerging evidence suggests that SARS-CoV-2 infection and vaccines may trigger autoimmune responses in predisposed individuals. Idiopathic inflammatory myopathies (IIMs) are diseases with diverse clinical manifestations, often associated myositis autoantibodies (MAs). Diagnosing IIM is challenging due to limitations classification criteria diagnostic assays. This study aimed describe the incidence of following or vaccination compare rates between exposures. Methods: A multicenter...
Abstract Objectives ANA are the most extensively used test for diagnosis of systemic autoimmune diseases. However, testing by indirect immunofluorescence assays (IIFAs) on HEp-2 cells, gold standard test, is time-consuming and needs expertise. Thus there a trend to replace it with other automated solid-phase directed against specific ANA. Nonetheless, Hep-2 cell an autoantigen array have been classified into 29 types, some them no clear association specificity be detected. It especially in...
Humoral alloimmunity, particularly that triggered by preformed antibodies against human leukocyte antigens (HLA), is associated with an increased prevalence of rejection and reduced transplant survival. The high sensitivity solid phase assays, based on microbeads coated single (SAB), consolidated them as the gold-standard method to characterize anti-HLA antibodies, ensuring a successful allograft allocation. Mean fluorescence intensity (MFI) provided SAB regularly used stratify immunological...
Inducing tolerance in Hymenoptera-allergic patients, bee venom immunotherapy (BVIT) is a widely accepted method to treat severe allergy stings. In order increase the existing knowledge on underlying immunological mechanisms and look for possible biomarkers predictive of efficacy, group 20 bee-venom-allergic patients (AG) were thoroughly examined during their first year BVIT. addition, results treated with those an untreated tolerant beekeepers (TG) who had previously shown firm...
Abstract Background One hundred fifty million contagions, more than 3 deaths and little 1 year of COVID-19 have changed our lives health management systems forever. Ageing is known to be one the significant determinants for severity. Two main reasons underlie this: immunosenescence age correlation with comorbidities such as hypertension or dyslipidaemia. This study has two aims. The first obtain cut-off points laboratory parameters that can help us in clinical decision-making. second analyse...
The potential use of fetal cells circulating in maternal blood for a non-invasive prenatal diagnosis has been widely described. Several authors have developed different methods the enrichment from peripheral blood. aim this study was to make practical valuation new technique, using those described as efficient and easy carry out unit. These consist double-density gradient positive selection by magnetic activated cell sorting (MACS) erythroblasts, posterior applying FISH interphasic...
<i>Background:</i> Spanish gypsies have traditionally lived as nomads, a reason why few epidemiological studies were done in this ethnic group. However, the high prevalence of asthmatic diseases demonstrated population residing North Spain induces us to analyse whether it was due influence genetic loci previously implicated other causing disorders. <i>Methods:</i> DRB1* and DQB1* HLA class II, TCR-Vα8.1, Fc&#917;RI-β <i>Rsa</i> I exon 7 intron 2, TNF-β...