A5023498945- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Mosquito-borne diseases and control
- Tattoo and Body Piercing Complications
- Research on Leishmaniasis Studies
- Empathy and Medical Education
- Trypanosoma species research and implications
- Body Image and Dysmorphia Studies
- Insect symbiosis and bacterial influences
- Prion Diseases and Protein Misfolding
- Brucella: diagnosis, epidemiology, treatment
- Machine Learning in Healthcare
- Stress Responses and Cortisol
- Drug-Induced Hepatotoxicity and Protection
- PI3K/AKT/mTOR signaling in cancer
- Hepatitis C virus research
- Cardiac Arrest and Resuscitation
- Antibiotic Use and Resistance
- Leptospirosis research and findings
Hospital Universitario Reina Sofía
2016-2024
Instituto de Investigación Biomédica de Salamanca
2019-2023
Complejo Hospitalario de Salamanca
2019-2023
Universidad de Salamanca
2019-2023
University of California, Irvine
2023
Cordoba University
2022
Jan Kochanowski University
2022
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2022
Hospital Juan Ramón Jiménez
2020
University of Córdoba
2016
The SARS-CoV-2 infection has widely spread to become the greatest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.22%, far higher than those reported in Asia or other European countries. A multicentre retrospective study of demographic, clinical, laboratory and immunological features 584 hospitalized patients their outcomes was...
Background Efficient and early triage of hospitalized Covid-19 patients to detect those with higher risk severe disease is essential for appropriate case management. Methods We trained, validated, externally tested a machine-learning model identify who will die or require mechanical ventilation during hospitalization from clinical laboratory features obtained at admission. A development cohort 918 was used training internal validation, 352 another hospital were external testing. Performance...
Objectives. To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19. Methods. We designed a multicenter retrospective cohort study three teaching hospitals Castilla y León, Spain (865,096 people). selected confirmed COVID-19 and lung involvement pO2/FiO2<300, excluding those exposed to immunosuppressors before or during hospitalization, terminally ill at admission, who died first 24 hours. performed propensity score matching (PSM)...
ObjectiveThe aim of this study was to analyze the epidemiological impact murine typhus in patients who required hospitalization National Health System (SNS) Spain between 1997 and 2015.BackgroundMurine (MT) is a zoonosis caused by Rickettsia typhi. MT transmitted from rats, cats, dogs, opossums humans their fleas. The clinical picture characterized headache, fever, rash, liver function alteration. prevalence considered underestimated since most cases are mild self-limited. However, up 10%...
(1) Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality recent years due to this fungus is not well established. The aim study was estimate case fatality rate aspergillosis inpatients from 1997 2017 Spain. (2) Methodology: A retrospective descriptive conducted with records admitted National Health System a diagnosis aspergillosis. (3) Principal findings: Of 32,960 inpatients, 24.5% deaths were registered, 71%...
Babesiosis is a zoonosis caused by an intraerythrocytic protozoan of the genus Babesia and transmitted mainly ticks Ixodes spp. complex. There no comprehensive global incidence in literature, although United States, Europe Asia are considered to be endemic areas. In Europe, percentage infected with ranges from 0.78% 51.78%. The babesiosis hospitalized patients Spain 2.35 cases per 10,000,000 inhabitants/year. mortality rate estimated approximately 9% but can reach 20% if disease...
The objective of this study was to assess the epidemiology and burden Q fever (QF) in Spain.We designed a retrospective descriptive using minimum basic data set patients admitted hospitals National Health System between 1998 2015 with diagnosis (ICD-9: 083.0.).We found 4214 hospitalized mean age (±SD) 50.9±19.3 years. male/female ratio 3:1. incidence rate 0.41 0.65 cases per 100,000 person-years over 18-year period. highest from March August (p=0.024). 21.1% had pneumonia, 17.5% liver...
The intensity of the thromboprophylaxis needed as a potential factor for preventing inpatient mortality due to coronavirus disease-19 (COVID-19) remains unclear.
Abstract BACKGROUND Efficient and early triage of hospitalized Covid-19 patients to detect those with higher risk severe disease is essential for appropriate case management. METHODS We trained, validated, externally tested a machine-learning model identify who will die or require mechanical ventilation during hospitalization from clinical laboratory features obtained at admission. A development cohort 918 was used training internal validation, 352 another hospital were external testing....
Brucellosis remains one of the main zoonoses worldwide. Epidemiological data on human brucellosis in Spain are scarce. The objective this study was to assess epidemiological characteristics inpatient between 1997 and 2015. A retrospective longitudinal descriptive performed. Data were requested from Health Information Institute Ministry Equality, which provided us with Minimum Basic Set patients admitted National System. We also obtained published System Obligatory Notifiable Diseases. total...
Psychological flexibility is a key concept of acceptation and commitment therapy (ACT). This factor has been linked with psychological wellbeing associated factors, such as quality life, in cancer patients. These other positive results patients found previous research could be enhanced by using mhealth tools. A three-arm randomized superiority clinical trial, pre-post-follow-up repeated measures intergroup design 1:1:1 allocation ratio proposed. hundred twenty will randomly assigned to one...
ABSTRACT Background SARS-CoV-2 infection has widely spread to the hugest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.94%, far higher those reported in Asia or other European countries. A multicenter retrospective study was performed of demographic, clinical, laboratory and immunological features 574 hospitalized patients their...
Background: The intensity of thromboprophylaxis as potential factor related to in-patient mortality associated COVID-19 remains unclear. Methods: This is a retrospective study evaluate the effect anticoagulation in unselected adults COVID-19. Patients were stratified according low molecular weight heparin (LMWH) regimen received: non-heparin, low-dose (standard dose prophylaxis) or high-dose (dose higher than standard prophylaxis). Findings: 690 patients included and median age was 72 years....
Hepatitis C virus (HCV) infection is a major public health problem that causes multiple comorbidities. People in prisons who inject intravenous drugs are at increased risk of HCV infection, and 15-fold more prevalent among prisoners compared with the community. The objective this study was to analyse clinical epidemiological characteristics residents Spanish prison received antiviral treatment.An observational, descriptive retrospective performed. All patients diagnosed or followed up an...
e13165 Background: Invasive lobular (L) breast carcinomas (BC), which account for up to 15% of all BC, had particularly histopathological characteristics: tends be estrogen/progesterone receptor positive and HER2-neu negative as such are treated with endocrine therapy (ET). It been demonstrated a frequent activation PI3K–AKT–mTOR signaling in LBCs, suggesting this pathway promising therapeutic target LBC. Interestingly, some these patients, the subsequent use mTOR inhibitor (everolimus)...
ABSTRACT Background: COVID-19 has high mortality in hospitalized patients, and we need effective treatments. Our objective was to assess corticosteroid pulses’ influence on 60-days patients with severe COVID-19, intensive care admission, hospital stay. Methods: We designed a multicenter retrospective cohort study three teaching hospitals of Castilla y León, Spain (865.096 people). selected confirmed lung involvement pO2/FiO2 < 300, excluding those exposed immunosuppressors before or...
e23143 Background: The genomic assays (GA) are acquiring an important role in helping the choice of adjuvant treatment for Early-stage Breast cancer (EBC). Data have value predicting benefit hormone therapy and risk recurrence at 5-10 years.We analyze two currently use GA determinations on EBC biopsies its involvement decisions period between January 2013 2015. Methods: Indications performing measurements different (reasons opportunity), Mammaprint (Symphony) PAM50 (Prosigna) were reviewed,...
Background: COVID-19 has high mortality in hospitalized patients, and we need effective treatments. Our objective was to assess corticosteroid pulses' influence on 60-days patients with severe COVID-19, intensive care admission, hospital stay. Methods: We designed a multicenter retrospective cohort study three teaching hospitals of Castilla y León, Spain (865.096 people). selected confirmed lung involvement pO2 /FiO2 < 300, excluding those exposed immunosuppressors before or during...