A5011652116- Immune Cell Function and Interaction
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- COVID-19 and healthcare impacts
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Plant-Microbe Interactions and Immunity
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Viral Infections and Immunology Research
- Liver Disease Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Plant Pathogenic Bacteria Studies
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Renal and Vascular Pathologies
- Intensive Care Unit Cognitive Disorders
- Cytomegalovirus and herpesvirus research
- Heart Failure Treatment and Management
- Glycogen Storage Diseases and Myoclonus
Hospital Clínico Universitario de Valladolid
2019-2024
Universidad de Valladolid
2021
Hospital Universitario Virgen del Rocío
2010-2019
Instituto de Biomedicina de Sevilla
2010-2019
Universidad de Sevilla
2012-2019
Hospital Universitario Ramón y Cajal
2019
Massachusetts General Hospital
2010
Universidad de Málaga
2003-2007
Genetic host factors may modify the course of hepatitis C virus (HCV) infection. Very recently, a genome-wide scan that reported association IL28B locus with response to treatment in HCV infection was published. The aim current study investigate relationship this outcome cohort constituted by total 731 Spanish individuals. From these, 284 were subjects persistent infection, 69 individuals who naturally cleared virus, and 378 noninfected subjects. Genotyping rs12979860 (C>T) performed...
Introduction Prognosis of Coronavirus disease 2019 (Covid-19) patients with vascular risk factors, and certain comorbidities is worse. The impact chronic neurological disorders (CND) on prognosis unclear. We evaluated if the presence CND in Covid-19 a predictor higher in-hospital mortality. As secondary endpoints, we analyzed association between CND, severity, laboratory abnormalities during admission. Methods: Retrospective cohort study that included all consecutive hospitalized confirmed...
The SARS-CoV-2 infection has widely spread to become the greatest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.22%, far higher than those reported in Asia or other European countries. A multicentre retrospective study of demographic, clinical, laboratory and immunological features 584 hospitalized patients their outcomes was...
Abstract Background. Human immunodeficiency virus type 1 (HIV-1) controllers maintain HIV-1 viremia at low levels (normally <2000 HIV-RNA copies/mL) without antiretroviral treatment. However, some have evidence of immunologic progression with marked CD4+ T-cell decline. We investigated host genetic factors associated protection against loss in controllers. Methods. analyzed the association interferon-lambda 4 (IFNL4)–related polymorphisms and human leukocyte antigen (HLA)-B haplotypes...
Abstract Background Stratification of the severity infection is currently based on Sequential Organ Failure Assessment (SOFA) score, which difficult to calculate outside ICU. Biomarkers could help stratify in surgical patients. Methods Levels ten biomarkers indicating endothelial dysfunction, 22 emergency granulopoiesis, and six denoting neutrophil degranulation were compared three groups patients first 12 h after diagnosis at Spanish hospitals. Results There 100 with infection, 95 sepsis 57...
ABSTRACT Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is a serious complication in patients undergoing cardiac surgery with extracorporeal circulation (ECC) that increases postoperative complications and mortality. CSA-AKI develops due to combination of patient- surgery-related risk factors enhance renal ischemia–reperfusion injury. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) such as empagliflozin reduce glucose reabsorption, improving tubulo-glomerular...
The single-nucleotide polymorphism (SNP) rs12979860 near the IL28B gene has been associated with spontaneous clearance of hepatitis C virus. We sought to determine whether this SNP could be control human immunodeficiency virus (HIV) infection. studied prevalence CC genotype among 53 white HIV controllers, compared 389 HIV-infected noncontrollers. found that was independently (odds ratio [OR], 2.669; P = .017), as were female sex (OR, 7.077; ≤ .001) and presence HLA-B57 and/or B27 3.080;...
Currently, the diagnosis of kidney allograft rejection relies on individual histological assessments made by expert pathologists according to Banff classification. In this study, we applied New Computer-Assisted System Technology (newCAST™) Visiopharm® with aim identifying and quantifying immune cells in inflammatory infiltrates. We searched for distinctive cellular profiles that could be assigned each category schema: antibody-mediated (active chronic active), borderline, T cell-mediated...
Abstract Background One hundred fifty million contagions, more than 3 deaths and little 1 year of COVID-19 have changed our lives health management systems forever. Ageing is known to be one the significant determinants for severity. Two main reasons underlie this: immunosenescence age correlation with comorbidities such as hypertension or dyslipidaemia. This study has two aims. The first obtain cut-off points laboratory parameters that can help us in clinical decision-making. second analyse...
ABSTRACT The hepatitis A virus cellular receptor 1 (HAVCR1) gene is highly polymorphic, and several variants have been associated with susceptibility to allergic autoimmune diseases. HAVCR1 region was identified as a candidate for C (HCV) natural clearance in genotyping study of selected immune response genes both European-American African-American populations. aim the present explore influence outcome HCV infection Spanish population. Three cohorts, consisting 354 subjects persistent (285...
ABSTRACT Background SARS-CoV-2 infection has widely spread to the hugest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.94%, far higher those reported in Asia or other European countries. A multicenter retrospective study was performed of demographic, clinical, laboratory and immunological features 574 hospitalized patients their...
Summary Studies on the association between peginterferon‐α and ribavirin levels sustained virological response ( SVR ) have shown yielded conflicting results, but most of them were performed before influence IL 28 B polymorphisms was known. Our aim to assess effects 2a plasma viral kinetics in hepatitis C virus genotype 1 HCV ‐1/ HIV ‐co‐infected patients according genotype. This a cohort study who ‐treatment naïve for whom efficacy plus evaluated by per‐protocol analysis. The measured ELISA...
Objectives: The association between anti-Ro/SSA antibodies and the appearance of cardiac rhythm disorders in adults is discussed. We aim to study this relationship, together with active treatments comorbidities, its impact on daily clinical practice systemic autoimmune diseases (SADs). Methods: This cross-sectional single-center was conducted a tertiary hospital January 2021 March 2022. A sample adult patients followed up SAD Unit diagnosis previously tested for anti-La/SSB were recruited....
The association between the DRB4*01:03:01:02N null allele and HLA‐DRB1*07~DQB1*03:03 haplotype has often been reported. Nevertheless, more unusual associations have also found in other countries, such as its with HLA‐DRB1*04 . HLA class I II antigen typing is currently performed using DNA‐based methods, making it difficult to identify alleles than if serological methods were used. Furthermore, DRB3/4/5 loci are not usually studied. However, identification of non‐expressed great importance...