A5086285959- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Celiac Disease Research and Management
- Adenosine and Purinergic Signaling
- Salivary Gland Disorders and Functions
- Hypertrophic osteoarthropathy and related conditions
- Immunodeficiency and Autoimmune Disorders
- Hematological disorders and diagnostics
- interferon and immune responses
- Lymphatic System and Diseases
- Dermatological and COVID-19 studies
- Renal Transplantation Outcomes and Treatments
- Parvovirus B19 Infection Studies
- Chemokine receptors and signaling
- IL-33, ST2, and ILC Pathways
- Dialysis and Renal Disease Management
- Kawasaki Disease and Coronary Complications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Universitat Autònoma de Barcelona
2021-2025
Vall d'Hebron Hospital Universitari
2020-2025
Vall d'Hebron Institut de Recerca
2021-2025
Kangbuk Samsung Hospital
2023
Soongsil University
2023
Yonsei University
2023
Hospital de Clínicas de Porto Alegre
2023
The SARS-CoV-2 infection has widely spread to become the greatest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.22%, far higher than those reported in Asia or other European countries. A multicentre retrospective study of demographic, clinical, laboratory and immunological features 584 hospitalized patients their outcomes was...
Hereditary angioedema (HAE) is a rare genetic disease, characterized by transient and self-limiting episodes of subcutaneous or submucosal swelling that spontaneously resolve within two to five days. The most common form HAE, HAE-C1-INH, caused deleterious mutations in the SERPING1 gene, encoding C1-Inhibitor protein, its diagnosis confirmed decreased C1-INH function. Distinctively from other forms up 15-20% HAE-C1-INH cases are sporadic de novo mutations. Here, we report patient with...
To analyse the prevalence, clinical characteristics, overall survival and event-free (EFS) of SSc patients who express anti-U11/U12 RNP (RNPC-3) antibodies.A total 447 from Barcelona (n = 286) Milan 161) were selected. All samples tested using a particle-based multi-analyte technology. We compared anti-RNPC-3 positive negative patients. Epidemiological, features analysed. End-stage lung disease (ESLD) was defined if patient developed forced vital capacity <50% predicted, needed oxygen...
Autoantibodies are a hallmark feature of Connective Tissue Diseases (CTD). Their presence in patients with idiopathic interstitial lung disease (ILD) may suggest covert CTD. We aimed to determine the prevalence CTD autoantibodies diagnosed ILD. 499 patient sera were analysed: 251 pulmonary fibrosis (IPF), 206 non-specific pneumonia (iNSIP) and 42 cryptogenic organising (COP). Autoantibody status was determined by immunoprecipitation. 2.4% IPF had CTD-autoantibody compared 10.2% iNSIP 7.3%...
Atypical hemolytic uremic syndrome (aHUS) is a complement system (CS)-mediated ultrarare disease that manifests as thrombotic microangiopathy (TMA) with preferential small kidney vessels involvement. Transient CS activation also observed in secondary TMA or patients at risk of developing aHUS. There no gold standard test to monitor activity; however, the
Abstract Objectives Systemic sclerosis (SSc)-specific autoantibodies allow the diagnosis and predict prognosis of SSc patients with different clinical characteristics. The aim this study was to describe new SSc-related by a novel protein immunoprecipitation (IP) assay. Methods Serum samples data were collected from 307 patients. Antinuclear tested in all indirect immunofluorescence (IIF) on HEp-2 cells. SSc-specific evaluated commercial immunoblot chemiluminescence immunoassay, traditional...
Abstract Background One hundred fifty million contagions, more than 3 deaths and little 1 year of COVID-19 have changed our lives health management systems forever. Ageing is known to be one the significant determinants for severity. Two main reasons underlie this: immunosenescence age correlation with comorbidities such as hypertension or dyslipidaemia. This study has two aims. The first obtain cut-off points laboratory parameters that can help us in clinical decision-making. second analyse...
ABSTRACT Background SARS-CoV-2 infection has widely spread to the hugest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.94%, far higher those reported in Asia or other European countries. A multicenter retrospective study was performed of demographic, clinical, laboratory and immunological features 574 hospitalized patients their...
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is characterized by hypercytokinemia leading to overwhelming inflammation. We describe the use of a hemadsorption device as part supportive treatment for cytokine storm.
Two years since the onset of COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms contribution laboratory variables is limited.To measure performance currently used tests alone or combined with explore power immunological adequate laboratories. Methods: Data from 2,600 patients first wave Barcelona area (exploratory cohort 1,579, validation cohorts 598 423 patients) including parameters were retrospectively collected. 28-day...
<h3>Background</h3> Chronic intestinal pseudo-obstruction (CIPO) is one of the gastrointestinal manifestations related to systemic sclerosis (SSc). Despite its low incidence (5%), it burdens a high morbimortality. <h3>Objectives</h3> The objective present study was analyse selected cohort patients with SSc and CIPO describe treatments they received, response them clinical outcome. <h3>Methods</h3> diagnosed were for study. There analysed baseline variables, period between diagnosis CIPO,...
The objective of the study was to analyze and describe concentrations eculizumab complement blockade in patients with atypical hemolytic uremic syndrome (aHUS) C3 glomerulopathy, define a therapeutic margin where there is high probability achieving efficacy.
<h3>Background</h3> Interstitial Lung Disease (ILD) is detected in 80% of the high resolution CT scans (HRCT) patients with Systemic Sclerosis (SSc). ILD responsible for 60% mortality related to SSc. Although classic treatment based on immunosuppressant therapies, nintedanib has recently been approved SSc-ILD as disease modifying antifibrotic drug. <h3>Objectives</h3> To describe safety and effectiveness over one year follow-up a cohort patients. <h3>Methods</h3> Basal characteristics SSc...
<h3>Background</h3> It has been reported that 80-85% of established systemic sclerosis (SSc) patients present anti-nuclear autoantibodies (ANAs) [1]. However, in a group clinically heterogeneous with high-titer ANAs no SSc-specific are found. is likely these have not previously described. Protein immunoprecipitation (IP) followed by mass spectrometry (MS) the potential to identify new autoantibodies. <h3>Objectives</h3> To novel through protein IP assay based on bioorthogonal non-canonical...
analizar y describir las concentraciones de eculizumab el bloqueo del complemento en los pacientes con síndrome hemolítico urémico atípico (SHUa) glomerulopatía C3, definir un margen terapéutico donde se alcance una alta probabilidad conseguir eficacia terapéutica. estudio observacional, ambispectivo multicéntrico que incluyó adultos pediátricos diagnosticados SHUa C3 desde septiembre 2020 hasta octubre 2022 5 hospitales España. Eculizumab administró a dosis recomendadas por la ficha...
Background: Almost two years after the onset of COVID–19 pandemic no predictive algorithm has been generally adopted nor new tests to improve prediction/management have added clinical laboratory toolbox for SARS–CoV2 infection. Methods: Retrospective observational analysis performance parameters and in hospitalized patients from first wave were assessed. Outcomes 28–d survival maximal severity a cohort 1,579 validation cohorts 598 434 patients. A pilot study measured 17 cytokines 27...
Abstract Background Almost two years since the onset of COVID-19 pandemic no predictive algorithm has been generally adopted, nor new tests identified to improve prediction and management SARS-CoV-2 infection. Methods Retrospective observational analysis performance clinical parameters laboratory in hospitalised patients with COVID-19. Outcomes were 28-day survival maximal severity a cohort 1,579 validation cohorts 598 434 patients. A pilot study conducted patient subgroup measured 17...
Background: Gastric antral vascular ectasia (GAVE) is one of the gastrointestinal (GI) manifestations related to systemic sclerosis (SSc). It can be presented as iron deficiency anemia or even upper bleeding. GAVE diagnosed by endoscopy observing an image confluent ectasias that oriented longitudinally on folds antrum in appearance “watermelon”. The definitive treatment for this manifestation consists guided fulguration when clinical situation allows it. Objectives: objective was study a...