A5065415092- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Nutritional Studies and Diet
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Biomedical Text Mining and Ontologies
- Long-Term Effects of COVID-19
- Advanced Proteomics Techniques and Applications
- Nutrition and Health in Aging
- Histone Deacetylase Inhibitors Research
- GDF15 and Related Biomarkers
- Data Analysis with R
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Nutrition, Genetics, and Disease
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cancer-related Molecular Pathways
- Biochemical and Molecular Research
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Semantic Web and Ontologies
Duke University
2024-2025
Universitat de Barcelona
2020-2024
Instituto de Salud Carlos III
2020-2024
Centro Nacional de Microbiologia
2024
Duke University Hospital
2024
Duke Medical Center
2024
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2020-2023
FC Barcelona
2023
Institute of Agrifood Research and Technology
2021-2022
Vall d'Hebron Institute of Oncology
2022
Fatty acids play prominent roles in brain function as they participate structural, metabolic and signaling processes. The homeostasis of fatty related pathways is known to be impaired cognitive decline dementia, but the relationship between these disturbances common risk factors, namely ɛ4 allele apolipoprotein E (ApoE-ɛ4) gene sex, remains elusive.In order investigate early alterations associated with acid-related serum metabolome, we here applied targeted metabolomics analysis on a nested...
The MaPLE study was a randomized, controlled, crossover trial involving adults ≥60 y.o. (n = 51) living in residential care facility during an 8-week polyphenol-rich (PR)-diet. Results from the showed that PR-diet reduced intestinal permeability (IP) older by inducing changes to gut microbiota (GM). present work aimed at studying serum metabolome trial, as further necessary step depict complex crosstalk between dietary polyphenols, GM, and barrier.Serum monitored using semi-targeted...
Dietary polyphenols can alter the gut microbiota (GM) and promote production of bioactive metabolites. Several indoles result GM metabolism dietary tryptophan have been associated with intestinal barrier integrity. Our aim is to study changes in GM-derived during a polyphenol-rich (PR) diet intervention older adults.Randomized, controlled, crossover trial adults ≥ 60 years living residential care facility an 8-week PR versus control (n = 51). Seven GM-tryptophan metabolites are measured...
Abstract Nutrition research can be conducted by using two complementary approaches: (i) traditional self-reporting methods or (ii) via metabolomics techniques to analyze food intake biomarkers in biofluids. However, the complexity and heterogeneity of these very different types data often hinder their analysis integration. To manage this challenge, we have developed a novel ontology that describes associated metabolite entities hierarchical way. This uses formal naming system, category...
Metabolomics and proteomics, like other omics domains, usually face a data mining challenge in providing an understandable output to advance biomarker discovery precision medicine. Often, statistical analysis is one of the most difficult challenges it critical subsequent biological interpretation results. Because this, combined with computational programming skills needed for this type analysis, several bioinformatic tools aimed at simplifying metabolomics proteomics have emerged. However,...
Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented often inconsistent.
Understanding how cellular pathways interact is crucial for treating complex diseases like cancer, yet our ability to map these connections systematically remains limited. Individual gene-gene interaction studies have provided insights 1,2 , but they miss the emergent properties of working together. To address this challenge, we developed a multi-gene approach pathway mapping and applied it CRISPR data from Cancer Dependency Map 3 . Our analysis electron transport chain revealed certain...
Diet is one of the most important modifiable lifestyle factors in human health and chronic disease prevention. Thus, accurate dietary assessment essential for reliably evaluating adherence to healthy habits.The aim this study was identify urinary metabolites that could serve as robust biomarkers diet quality, assessed through Alternative Healthy Eating Index (AHEI-2010).We set up two-center samples 160 volunteers, aged between 25 50, living a couple or family, with repeated urine sampling at...
Objective Early lifestyle interventions in children with obesity decrease risk of and metabolic disorders during adulthood. This study aimed to identify signatures associated intervention urine samples from prepubertal obesity. Methods Thirty‐four were studied before after a 6‐month program, anthropometric, metabolic, nutritional variables collected. A nuclear magnetic resonance approach was applied obtain the metabolomic profile samples. Partial least squares‐discriminant analysis (PLS‐DA)...
Since its creation in 2016, the FoodOn food ontology has become an interconnected partner various academic and government projects that span agricultural public health domains. This paper examines recent data interoperability capabilities arising from food-related ontologies belonging to, or compatible with, encyclopedic Open Biological Biomedical Ontology Foundry (OBO) platform, how research organizations industry might utilize them for their own exchange. Projects are seeking standardized...
Fewer than 20% of triple-negative breast cancer patients experience long-term responses to mainstay chemotherapy. Resistant tumor subpopulations use alternative metabolic pathways escape therapy, survive, and eventually recur. Here, we show in vivo, longitudinal reprogramming residual disease recurrence xenografts with varying sensitivities the chemotherapeutic drug paclitaxel. Optical imaging coupled metabolomics reported an increase non–glucose–driven mitochondrial metabolism intratumoral...
Drug tolerant persister (DTP) cells enter into a reversible slow-cycling state after drug treatment. We performed proteomic characterization of the breast cancer (BC) DTP cell secretome eribulin showed that growth differentiation factor 15 (GDF15) is protein significantly over-secreted upon The biomarker potential GDF15 was confirmed in 3D-cell culture models using BC lines and PDXs, as well TNBC vivo model. also found required for survival cells. Direct participation its receptor GFRAL...
Scope Evidence on the Mediterranean diet (MD) and age‐related cognitive decline (CD) is still inconclusive partly due to self‐reported dietary assessment. The aim of current study develop an MD‐ metabolomic score (MDMS) investigate its association with CD in community‐dwelling older adults. Methods results This includes participants from Three‐City Study Bordeaux ( n = 418) Dijon 422) cohorts who are free dementia at baseline. Repeated measures cognition over 12 years collected. An MDMS...
Two years since the onset of COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms contribution laboratory variables is limited.To measure performance currently used tests alone or combined with explore power immunological adequate laboratories. Methods: Data from 2,600 patients first wave Barcelona area (exploratory cohort 1,579, validation cohorts 598 423 patients) including parameters were retrospectively collected. 28-day...
Abstract Integrating high-dimensional cellular multi-omics data is crucial for understanding various layers of biological control. Single ‘omic methods provide important insights, but often fall short in handling the complex relationships between genes, proteins, metabolites and beyond. Here, we present a novel, non-linear, unsupervised method called GAUDI (Group Aggregation via UMAP Data Integration) that leverages independent embeddings concurrent analysis multiple types. uncovers...
ABSTRACT Epstein-Barr virus (EBV) is a gamma herpesvirus that infects up to 95% of the human population by adulthood, typically remaining latent in host memory B cell pool. In immunocompromised individuals, EBV can drive transformation and rapid proliferation infected cells, ultimately resulting neoplasia. The same process be induced vitro , with EBV-infected peripheral blood mononuclear cells (PBMCs) forming immortalized lymphoblastoid lines (LCLs) within weeks. this study, we found fatty...
The aim of this study was to assess the effects a mixture four dietary fibers on obese rats. Four groups male Wistar rats were fed with either standard chow (STD) or cafeteria diet (CAF) and orally supplemented fibre (2 g kg
Nutrition research can be conducted by using two complementary approaches: (i) traditional self-reporting methods or (ii) via metabolomics techniques to analyze food intake biomarkers in biofluids.However, the complexity and heterogeneity of these very different types data often hinder their analysis integration.To manage this challenge, we have developed a novel ontology that describes associated metabolite entities hierarchical way.This uses formal naming system, category definitions,...
SUMMARY Ewing Sarcoma (EwS) is an aggressive bone and soft tissue tumor driven by the fusion oncoprotein EWSR1-FLI1. This aberrant transcription factor binds to GGAA microsatellites, causing epigenetic reprogramming through formation of active neo-enhancers in a permissive cellular context. Inhibition oncogene remains challenging current efforts instead seek exploit emergent treatments targeting EWSR1-FLI1 cofactors. Here, stemming from genome-wide redistribution H3K27me3 upon expression...
Background: Almost two years after the onset of COVID–19 pandemic no predictive algorithm has been generally adopted nor new tests to improve prediction/management have added clinical laboratory toolbox for SARS–CoV2 infection. Methods: Retrospective observational analysis performance parameters and in hospitalized patients from first wave were assessed. Outcomes 28–d survival maximal severity a cohort 1,579 validation cohorts 598 434 patients. A pilot study measured 17 cytokines 27...
Abstract Background Almost two years since the onset of COVID-19 pandemic no predictive algorithm has been generally adopted, nor new tests identified to improve prediction and management SARS-CoV-2 infection. Methods Retrospective observational analysis performance clinical parameters laboratory in hospitalised patients with COVID-19. Outcomes were 28-day survival maximal severity a cohort 1,579 validation cohorts 598 434 patients. A pilot study conducted patient subgroup measured 17...
The FOBI ontology can be of great help in nutrimetabolomic studies due to its wide variety applications, including the possibility performing different enrichment analyses. However, programming skills required query and explore it may limit use by scientific community.Here, we present fobitools framework, comprised an R/Bioconductor package complementary web interface. These two tools allow researchers interact a highly user-friendly way. framework is focused on novel concept food analysis...