A5001488716- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Tea Polyphenols and Effects
- Consumer Attitudes and Food Labeling
- Nutrition and Health in Aging
- Frailty in Older Adults
- Advanced Chemical Sensor Technologies
- Physical Activity and Health
- Biofuel production and bioconversion
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Bioenergy crop production and management
- Gut microbiota and health
- Copper-based nanomaterials and applications
- Opioid Use Disorder Treatment
- Multiple and Secondary Primary Cancers
- Health, psychology, and well-being
- Dietetics, Nutrition, and Education
- Nitrogen and Sulfur Effects on Brassica
- Delphi Technique in Research
- Genetically Modified Organisms Research
- Pain Management and Opioid Use
- Prostate Cancer Treatment and Research
- Lipid metabolism and biosynthesis
Aberystwyth University
2013-2025
Institute of Biological, Environmental and Rural Sciences
2014-2022
Bangor University
2012-2015
Background/Objectives: Dartmoor Estate Tea plantation in Devon, UK, is renowned for its unique microclimate and varied soil conditions, which contribute to the distinctive flavours chemical profiles of tea. The diversity fresh leaf samples from different were assessed via collected various garden locations within plantation. Methods: Fresh leaf, differed by location, cultivar, time day, variety, analysed using Flow Infusion Electrospray Ionisation Mass Spectrometry (FIE-MS). Results: Random...
Background/Objectives: Dartmoor Estate Tea plantation in Devon, UK, is renowned for its unique microclimate and varied soil conditions, which contribute to the distinctive flavours chemical profiles of tea. The diversity fresh leaf samples from various garden locations was explored within plantation. Methods: Fresh leaf, differed by location, cultivar, time day, variety, analysed using Flow Infusion Electrospray Ionisation Mass Spectrometry (FIE-MS). Results: Random forest classification...
Background/Objectives: Cardiovascular diseases remain a leading cause of mortality and morbidity, dyslipidaemia is one the major risk factors. The widespread use herbs medicinal plants in traditional medicine has garnered increasing recognition as valuable resource for wellness reducing onset disease. Several epidemiologic clinical studies have shown that altering blood lipid profiles maintaining gut homeostasis may protect against cardiovascular diseases. Methods: A randomised,...
<ns3:p>Introduction Current dietary assessment methods struggle to accurately capture individuals’ habits. The ‘Standardised and Objective Dietary Intake Assessment Tool’ (SODIAT)-1 study aims assess the effectiveness of three emerging technologies (urine capillary blood biomarkers, wearable camera technology) two online self-reporting tools monitor intake. Methods This randomised controlled crossover trial was conducted at sites (Hammersmith Hospital University Reading) aimed recruit 30 UK...
The purpose of this study was to use high accurate mass metabolomic profiling investigate differences within a phenotypically diverse canine population, with breed-related morphological, physiological and behavioural differences. Previously, using broad metabolite fingerprinting approach, lipids appear dominate inter- intra- breed discrimination. here Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS) identify in more detail, inter-breed signatures...
CuH is a material that appears in wide diversity of circumstances ranging from catalysis to electrochemistry organic synthesis. There are both aqueous and nonaqueous synthetic routes CuH, each which apparently leads different product. We developed methodologies enable multigram quantities be produced by characterized product combination spectroscopic, diffraction computational methods. The results show that, while all methods for the synthesis result same bulk product, path taken engenders...
Diet is one of the most important modifiable lifestyle factors in human health and chronic disease prevention. Thus, accurate dietary assessment essential for reliably evaluating adherence to healthy habits.The aim this study was identify urinary metabolites that could serve as robust biomarkers diet quality, assessed through Alternative Healthy Eating Index (AHEI-2010).We set up two-center samples 160 volunteers, aged between 25 50, living a couple or family, with repeated urine sampling at...
Bluebell seeds were collected from the same location for five different growth periods (2006–2010). The composition of fatty acids in triacylglycerols present bluebell was determined using 1H- and 13C NMR GC-MS acid methyl esters with good agreement between methods analysis proportion individual acids. seed oil comprised 80% ω-9 monounsaturated (C18:1, C20:1, C22:1), 10% ω-6,9 biunsaturated (C18:2) saturated (C16:0, C18:0, C20:0, C22:0). contained 25% 20 or 22 carbon chain length. Gondoic...
Dietary exposure monitoring within populations is reliant on self-reported measures such as Food Frequency Questionnaires and diet diaries. These methods often contain inaccurate information due to participant misreporting, non-compliance bias. Urinary metabolites derived from individual foods could provide additional objective indicators of dietary exposure. For biomarker approaches have utility it essential that they cover a wide-range commonly consumed the methodology works in real-world...
Scope Dietary choices modulate the risk of chronic diseases and improving diet is a central component public health strategies. Food‐derived metabolites present in urine could provide objective biomarkers dietary exposure. To assist biomarker validation, this work aims to develop food intervention strategy mimicking typical annual over short period time assesses sampling protocols potentially suitable for future deployment technology free‐living populations. Methods results Six different...
<ns3:p>Introduction Current dietary assessment methods face challenges in accurately capturing individuals’ habits, undermining the efficacy of public health strategies. The ‘Standardised and Objective Dietary Intake Assessment Tool’ (SODIAT)-1 study aims to assess effectiveness three emerging technologies (urine capillary blood biomarkers, wearable camera technology) two online self-reporting tools monitor intake. Methods This randomised controlled crossover trial will recruit 30...
Abstract Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert use studies via the Delphi method. A three-round study was conducted using online platform. In Round 1, panel members provided suggestions candidate ageing. Rounds 2 and 3, they voted 500 initial statements...
Copper(I) hydride (cuprous hydride, CuH) was the first binary metal to be discovered (in 1844) and is singular in that it synthesized solution, at ambient temperature. There are several synthetic paths CuH, one of which involves reduction an aqueous solution CuSO4·5H2O by borohydride ions. The product from this procedure has not been extensively characterized. Using a combination diffraction methods (X-ray neutron) inelastic neutron scattering spectroscopy, we show CuH route same bulk...
Abstract Objective: Obtaining objective, dietary exposure information from individuals is challenging because of the complexity food consumption patterns and limitations self-reporting tools (e.g., FFQ diet diaries). This hinders research efforts to associate intakes specific foods or eating with population health outcomes. Design: Dietary can be assessed by measurement food-derived chemicals in urine samples. We aimed develop methodologies for collection that minimised impact on day-to-day...
Metabolites derived from individual foods found in human biofluids after consumption could provide objective measures of dietary intake. For comprehensive assessment, quantification methods would need to manage the structurally diverse mixture target metabolites present at wide concentration ranges.A strategy for selection candidate exposure biomarkers is developed. An analytical method 62 food validated by extensive analysis chromatographic and ionization behavior characteristics using...
Older patients account for a significant proportion of undergoing colorectal cancer surgery and are vulnerable to number preoperative risk factors that not often present in younger patients. Further, three more prevalent older adults include frailty, sarcopenia, malnutrition. Although each these has been studied isolation, there is little information on the interplay between them surgical A particular area increasing interest use urine metabolomics objective evaluation dietary profiles...
Abstract Introduction Flow infusion electrospray high resolution mass spectrometry (FIE-HRMS) fingerprinting produces complex, dimensional data sets which require specialist in-silico software tools to process the prior analysis. Objectives Present spectral binning as a pragmatic approach post-acquisition procession of FIE-HRMS metabolome data. Methods A was developed that included elimination single scan m/z events, spectra and averaging across profile. The modal accurate then extracted for...
Metabolites derived from specific foods present in urine samples can provide objective biomarkers of food intake (BFIs). This study investigated the possibility that calystegines (a class iminosugars) may BIFs for potato (Solanum tuberosum L.) product exposure.Calystegine content is examined published data covering a wide range cultivars. Rapid methods are developed quantification cooked products and human using triple quadrupole mass spectrometry. The potential as BFIs consumption assessed...