A5070285268- Metabolomics and Mass Spectrometry Studies
- Tea Polyphenols and Effects
- Diet and metabolism studies
- Nutritional Studies and Diet
- Metabolism and Genetic Disorders
- Plant and fungal interactions
- Botanical Research and Chemistry
- Epilepsy research and treatment
- Patient Dignity and Privacy
- Grief, Bereavement, and Mental Health
- Palliative Care and End-of-Life Issues
- Tryptophan and brain disorders
- Prenatal Substance Exposure Effects
- Schizophrenia research and treatment
- Advanced Chemical Sensor Technologies
- Alcohol Consumption and Health Effects
- Advanced Proteomics Techniques and Applications
- Ginseng Biological Effects and Applications
- Nursing Roles and Practices
- Alcoholism and Thiamine Deficiency
- Balance, Gait, and Falls Prevention
- Fermentation and Sensory Analysis
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Food Quality and Safety Studies
Aberystwyth University
2019-2025
Western University
2019-2023
University College London
2019-2023
Institute of Biological, Environmental and Rural Sciences
2019-2022
Camden and Islington NHS Foundation Trust
2021
St Pancras Hospital
2021
The University of Melbourne
2020
Austin Health
2020
Peninsula Health
2020
Eastern Health
2016-2020
Background: The field of palliative care (PC) is growing as the world population ages and burden chronic diseases increases. Thus, it important that general public knowledgeable about PC benefits provides. Objective: aim this study to describe public’s knowledge, awareness, perceptions determine whether these have changed over time. Methods: A scoping literature review was conducted from 1968 May 2019 using PubMed, EMBASE, MEDLINE databases. Results: Thirteen studies met inclusion criteria...
Background/Objectives: Dartmoor Estate Tea plantation in Devon, UK, is renowned for its unique microclimate and varied soil conditions, which contribute to the distinctive flavours chemical profiles of tea. The diversity fresh leaf samples from different were assessed via collected various garden locations within plantation. Methods: Fresh leaf, differed by location, cultivar, time day, variety, analysed using Flow Infusion Electrospray Ionisation Mass Spectrometry (FIE-MS). Results: Random...
The authors investigated the clinical feasibility and outcome for patients of a program designed as an alternative to acute hospitalization.This was random-design study comparing conventional inpatient urban, poor, severely ill voluntary who usually require hospitalization experimental consisting day hospital linked crisis residence. Patients were assessed with standardized measures symptoms, functioning, social adjustment, quality life, satisfaction services upon admission study, at...
Many infancy-onset epilepsies have poor prognosis for seizure control and neurodevelopmental outcome. Ketogenic diets can improve seizures in children older than 2 years adults who are unresponsive to antiseizure medicines. We aimed establish the efficacy of a classic ketogenic diet at reducing frequency compared with further medicine infants drug-resistant epilepsy.
Background/Objectives: Dartmoor Estate Tea plantation in Devon, UK, is renowned for its unique microclimate and varied soil conditions, which contribute to the distinctive flavours chemical profiles of tea. The diversity fresh leaf samples from various garden locations was explored within plantation. Methods: Fresh leaf, differed by location, cultivar, time day, variety, analysed using Flow Infusion Electrospray Ionisation Mass Spectrometry (FIE-MS). Results: Random forest classification...
Background/Objectives: Cardiovascular diseases remain a leading cause of mortality and morbidity, dyslipidaemia is one the major risk factors. The widespread use herbs medicinal plants in traditional medicine has garnered increasing recognition as valuable resource for wellness reducing onset disease. Several epidemiologic clinical studies have shown that altering blood lipid profiles maintaining gut homeostasis may protect against cardiovascular diseases. Methods: A randomised,...
Abstract Objective: Obtaining objective, dietary exposure information from individuals is challenging because of the complexity food consumption patterns and limitations self-reporting tools (e.g., FFQ diet diaries). This hinders research efforts to associate intakes specific foods or eating with population health outcomes. Design: Dietary can be assessed by measurement food-derived chemicals in urine samples. We aimed develop methodologies for collection that minimised impact on day-to-day...
ABSTRACT The antiprotozoal effect of saponins varies according to both the structure sapogenin and composition linkage sugar moieties sapogenin. on protozoa has been considered be transient as it was thought that when were deglycosilated sapogenins in rumen they became inactive; however, no studies have yet evaluated compared their related saponins. aims this study evaluate eighteen commercially available triterpenoid steroid vitro, investigate variations moiety compare different bearing...
Metabolites derived from individual foods found in human biofluids after consumption could provide objective measures of dietary intake. For comprehensive assessment, quantification methods would need to manage the structurally diverse mixture target metabolites present at wide concentration ranges.A strategy for selection candidate exposure biomarkers is developed. An analytical method 62 food validated by extensive analysis chromatographic and ionization behavior characteristics using...
Abstract Introduction Flow infusion electrospray high resolution mass spectrometry (FIE-HRMS) fingerprinting produces complex, dimensional data sets which require specialist in-silico software tools to process the prior analysis. Objectives Present spectral binning as a pragmatic approach post-acquisition procession of FIE-HRMS metabolome data. Methods A was developed that included elimination single scan m/z events, spectra and averaging across profile. The modal accurate then extracted for...
Metabolites derived from specific foods present in urine samples can provide objective biomarkers of food intake (BFIs). This study investigated the possibility that calystegines (a class iminosugars) may BIFs for potato (Solanum tuberosum L.) product exposure.Calystegine content is examined published data covering a wide range cultivars. Rapid methods are developed quantification cooked products and human using triple quadrupole mass spectrometry. The potential as BFIs consumption assessed...
Improvement of diet at the population level is a cornerstone national and international strategies for reducing chronic disease burden. A critical challenge in generating robust data on habitual dietary intake accurate exposure assessment. Self-reporting instruments (e.g., food frequency questionnaires, recall) are subject to reporting bias serving size perceptions, while weighed assessments unfeasible large-scale studies. However, secondary metabolites derived from individual foods/food...
Background/Objectives: Cardiovascular diseases remain a leading cause of mortality and morbidity. The widespread use herbs medicinal plants in traditional medicine has garnered increasing recognition as valuable resource for wellness reducing the onset disease. Several epidemiologic clinical studies have shown that altering blood lipid profiles maintaining gut homeostasis may protect against cardiovascular diseases. Methods: A randomized, active-controlled parallel human trial (n = 52) with...
Abstract Although the potential of plants extracts to improve feed efficiency and animal productivity decrease methane emissions by enteric fermentation has been shown, information available is often contradictory which attributed differences in complex mixture bioactive compounds their interactions. Understanding degree structural features a compound may affect biological activity an extract essential. We hypothesised that relative small variations structure can have significant influence...
The purpose of this study was to determine whether the content patient education performed by physical therapists corresponds charted documentation. Audiotaped data from a previously published were compared with documented records for same patients indeed documented. Statements classified into one five categories: providing information about their illness, instruction home exercises, advice and information, general health education, stress counseling. A number percentage calculated each...
AbstractBackground The role of palliative care (PC) in chronic disease and end-of-life (EOL) management is rapidly evolving. However, studies globally have demonstrated limited public knowledge awareness PC with several misconceptions.Objective purpose was to expand upon previous Canadian by providing more current detailed information about the awareness, perceptions EOL management. Additionally, reliability self-reported explored.Methods A cross-sectional study using an 8-item questionnaire...
<h3></h3> The incidence of epilepsy is greatest in the first 2 years life. Although data exist for line treatment infantile spasms, are lacking other epilepsies as well effective second treatments all. ketogenic diet (KD) a high-fat, low-carbohydrate designed to mimic effects starvation on body. It has been shown be successful controlling seizures several observational studies, and two randomised controlled trials (RCTs) older children. No high-quality evidence available infants. KD infants...
In this study, Lippia origanoides Kunth, native to the Alto Patía region in Southwest Colombia, and P ichia guilliermondii LV196, an inactivated yeast from germplasm bank of Agrosavia (Colombian Agricultural Research Corporation), alone or combined, were tested for their long-term effect on rumen fermentation methanogenesis whilst also characterising bacterial methanogen communities. Whereas essential oils act through selective inhibition microbial groups, yeasts are thought work stimulation...