A5013040987- Epilepsy research and treatment
- Neonatal Respiratory Health Research
- RNA and protein synthesis mechanisms
- Hereditary Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- RNA Research and Splicing
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Health and Medical Research Impacts
- Genetics and Neurodevelopmental Disorders
- Preterm Birth and Chorioamnionitis
- Neonatal and fetal brain pathology
- Airway Management and Intubation Techniques
- Glioma Diagnosis and Treatment
- Digestive system and related health
- Pharmaceutical studies and practices
- Vascular anomalies and interventions
- Ginkgo biloba and Cashew Applications
- Congenital Heart Disease Studies
- Multiple Sclerosis Research Studies
- Spinal Dysraphism and Malformations
- Adolescent and Pediatric Healthcare
Oxford University Hospitals NHS Trust
2023-2025
John Radcliffe Hospital
2020
University of Oxford
2020
University Hospitals Bristol NHS Foundation Trust
2018
Bristol Royal Hospital for Children
2016
Leicester Royal Infirmary
2012-2013
University of Leicester
2010-2012
University Hospitals of Leicester NHS Trust
2012
National Institute of Mental Health and Neurosciences
2005-2006
Many infancy-onset epilepsies have poor prognosis for seizure control and neurodevelopmental outcome. Ketogenic diets can improve seizures in children older than 2 years adults who are unresponsive to antiseizure medicines. We aimed establish the efficacy of a classic ketogenic diet at reducing frequency compared with further medicine infants drug-resistant epilepsy.
Abstract Medicines and surgical interventions improve the quality of life Parkinson's disease (PD) patients. These are still expensive options unaffordable to those living in developing countries. Managing PD Indians who have a low annual gross national income (GNI; US$ 450–540) for whom only few (3%) health insurance is challenge. We interviewed 175 consecutive patients regarding money spent treatment. The nearly half was less than rupees 50,000 (US$ 1,148.63). Patients this study spend 16%...
Pathogenic variants in the Glycyl-tRNA synthetase gene cause allelic disorders Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuropathy V. We describe clinical features 8 unrelated patients found to have by Next Generation Sequencing. In addition upper limb predominant symptoms, other presentations included failure thrive, feeding difficulties lower dominant symptoms. Variability age at testing ranged from 14 months 59 years. The youngest being symptomatic 3...
Preterm birth is the major cause of neonatal and infant mortality in developed world, being responsible for 55% 43% deaths, respectively, England Wales.1 With nearly 50 000 preterm births (before 37 weeks gestation) a year Wales (7.6%), burden large research has estimated annual cost these babies to be £3 billion2 reflecting both initial care costs ongoing morbidity. To date, clinical response agenda have concentrated on two main areas: (1) optimising practices interventions (2) secondary...
<h3>Objectives</h3> To provide survival data and rates of severe disability at 2 years corrected age in infants born prior to 26 weeks9 gestation 2001–2003 compare these outcomes with an earlier cohort from 1991 1993. <h3>Design</h3> Population-based prospective study. <h3>Setting</h3> Former Trent region UK covering a population approximately five million around 55 000 births per annum. <h3>Participants</h3> The authors identified 3-year before between 1 January 2001 31 December 2003...
Abstract The prevalence of Parkinson's disease (PD) is low among Indians, except in the Parsis. Data for Indians come from studies using different screening tools and criteria to detect PD. An epidemiological study India, which has nearly a billion people, more than 18 spoken languages, varying levels literacy, requires development validation tool objectives this are (1) validate modified version widely used questionnaire PD suit needs Indian population; (2) compare use nonmedical assistant...
Clinical care of rare and complex epilepsies is challenging, because evidence-based treatment guidelines are scarce, the experience many physicians limited, interdisciplinary comorbidities required. The pathomechanisms are, however, increasingly understood, which potentially fosters novel targeted therapies. objectives our survey were to obtain an overview clinical practice in European tertiary epilepsy centers treating patients with 5 arbitrarily selected get estimate available for future studies.
Background Many infancy-onset epilepsies have a poor prognosis for seizure control and neurodevelopmental outcome. Ketogenic diets can improve seizures in older children adults unresponsive to antiseizure medicines. We aimed determine the effectiveness of ketogenic diet reducing frequency compared further medicine infants with drug-resistant epilepsy. Methods In this randomised, open-label trial, 136 epilepsy, aged 1–24 months, > 4 seizures/week previous trial ≥ 2 medicines were recruited...
Dear Sir, A 15-year-old boy presented to the and E department with weakness pins needles in both arms. He gave a history of fall from household trampoline hyperextension 3 days before presentation. reported neck pain on previous day. This was followed by numbness over shoulders, which progressed down arm forearms. On examination, there patchy sensory loss upper limbs, decreased power 4/5 MRC. Lower limb examination normal. Decreased limbs worse distally than proximally. There no spinal...
An 8-year-old girl presented with a subacute severe spastic paraparesis and loss of bladder control. Over the preceding few months she had mild occasional pins needles, perianal anaesthesia foot drop symptoms. Spinal MRI showed areas heterogeneous abnormal high T2 signal apparent cord expansion (figure 1). Gadolinium-enhanced images widespread enhancement throughout intramedullary compartment spinal particularly mid- …
<h3>Introduction</h3> IIH is characterised by raised intracranial pressure mostly affecting young females. It can lead to severe and irreversible visual loss. There little consensus or evidence based guidance for management, especially in children. We conducted a multi-centre retrospective service evaluation better understand current practice. <h3>Methods</h3> Children diagnosed with from nine centres the UK over 3 year period were retrospectively studied. Patient demographics, clinical...