A5056848185- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Medical and Biological Ozone Research
- HIV Research and Treatment
- Hydrogen's biological and therapeutic effects
- Infectious Encephalopathies and Encephalitis
- Inflammasome and immune disorders
- Renin-Angiotensin System Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Air Quality and Health Impacts
- Autoimmune and Inflammatory Disorders Research
- Acute Ischemic Stroke Management
- Climate Change and Health Impacts
- Stroke Rehabilitation and Recovery
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Intracranial Aneurysms: Treatment and Complications
- Linguistic Studies and Language Acquisition
- Calcium signaling and nucleotide metabolism
- Suicide and Self-Harm Studies
- Effects of Environmental Stressors on Livestock
- Viral Infections and Immunology Research
- Animal Ecology and Behavior Studies
- Cardiac Ischemia and Reperfusion
- Galectins and Cancer Biology
University of Havana
1972-2024
Hospital Universitario Virgen del Rocío
2010
Consejo Superior de Investigaciones Científicas
2002
Abstract Four kinds of infusions were made for 1 h periods into the 3rd cerebral ventricle hydrated, conscious goats: 1) Angiotensin in hypertonic NaCI, 2) angiotensin slightly hypotonic 3) isotonic d‐glucose, and 4) NaCI. The influence these on carotid blood pressure fluid balance was studied. NaCl had conspicuous hypertensive, dipsogenic, antidiuretic natriuretic effects. More moderate responses same obtained during In contrast, no or only weak effects by d‐glucose. results are taken as...
T lymphocytes can be activated via the cell receptor (TCR) or by triggering through a number of other surface structures, including CD38 co-receptor molecule. Here, we show that in TCR<sup>+</sup> cells express CD3-ζ lacking cytoplasmic domain, cross-linking with CD38- CD3-specific monoclonal antibodies induces tyrosine phosphorylation CD3-ε, ζ-associated protein-70, linker for activation cells, and Shc. Moreover, these anti-CD38 anti-CD3 stimulation leads to protein kinase B/Akt Erk...
Abstract Various hypertonic equi‐osmolal solutions were infused via permanently implanted catheters into the external carotid artery of conscious, hydrated goats. The infusions (1.5 ml/min) 1 M NaCl, 2 fructose and sucrose caused a marked inhibition water diuresis. effect was evidently due to release antidiuretic hormone (ADH) since it disappeared after induction diabetes insipidus. No response occurred during either glycerol or galactose, while weak seen glucose. Infusions urea gave...
Objective. The aim of this study was to investigate the possible role caspase 7 (CASP7) in susceptibility rheumatoid arthritis (RA). Methods. Genotyping three single nucleotide polymorphisms (SNPs) CASP7 gene: rs11593766 (G/ T), rs2227310 (C/G) and rs2227309 (G/A) performed a total 906 RA patients 528 matched healthy controls using TaqMan assays. All subjects were Spanish Caucasian origin. A relative quantification mRNA encoding non-functional variant procaspase (isoform β) vs functional...
Our hypothesis that controlled ozone applications interfere into the redox balance of biological organism (first published in 1998 with a preclinical trial on protecting liver from CCl4 intoxication), has been verified over last 2 decades reactive oxygen species (ROS)-induced mitochondrial pathologies, such as rheumatoid arthritis, osteoarthritis, aging processes, diabetes-2 and prevention intoxications. Low-dose acts bioregulator: The restoration disturbed is comprehensible number clinical...
In chronic inflammatory conditions and diseases accompanied by inflammation, the main indication range of systemically administered ozone, one basic mechanism action has emerged following low-dose ozone concept: Interference in diverse biological redox equilibria, its regulation at low concentrations. very special role glutathione balance recovery. It starts with oxidation GSH (active form glutathione) "ozone peroxides", after a considerable number regulatory processes mechanisms, finally...
Objective: Human immunodeficiency virus (HIV) infection is accompanied by metabolic and immunological dysfunctions. Oxidative stress has been associated to HIV infection, also its relation highly active antiretroviral therapy (HAART) suggested. This study assessed the effect of HAART combination (zidovudine/lamivudine/nevirapine) on redox indexes (RI) progression markers disease while monitoring drugs concentration in blood. Methods: Eighty subjects (40 taking 40 non-HAART) supposedly...
Objective: Highly active antiretroviral therapy (HAART) is the choice to treat cases with an established HIV-infection and prevent establishment of infection after exposure. Oxidative stress has been associated HIV and, depending combination, effectiveness adherence, HAART. This study assessed effect three different HAART combinations, i.e. zidovudine/lamivudine/nevirapine (I), zidovudine/lamivudine/indinavir (II) stavudine/lamivudine/nevirapine (III), on redox indexes progression markers...
A significant number of patients who have had cerebrovascular illness apparently recover their former abilities completely but return to normal life with subtle cognitive deficits which may affect daily lives. Such is the situation transitory ischemic accidents present sustained, undiagnosed attention deficits.To identify subclinical alterations due in accidents, and contribute study physiopathological mechanisms involved integration this function.We examined 44 persons, divided into three...